Zobrazeno 1 - 10
of 201
pro vyhledávání: '"OXPHOS (oxidative phosphorylation)"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/545954e957b84457a267d7d66ad95694
Rewiring of mitochondrial metabolism in therapy-resistant cancers: permanent and plastic adaptations
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many of the selective pressures encountered by tumor cells, such as exposure to anticancer therapies, navigation of the metastatic cascade, and communication wi
Externí odkaz:
https://doaj.org/article/797819a65faf4f8f8c019ce148927a74
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Dendritic cells (DCs) play crucial roles in the pathogenesis of rheumatoid arthritis (RA), a prototypic autoimmune disease characterized by chronic synovitis and joint destruction. Conventional dendritic cells (cDCs) with professional antigen-present
Externí odkaz:
https://doaj.org/article/8f3508abeff546ffb7fa264cd5022963
Autor:
Veronica Marabitti, Manuela Giansanti, Francesca De Mitri, Francesca Gatto, Angela Mastronuzzi, Francesca Nazio
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Tumor-specific alterations in metabolism have been recognized to sustain the production of ATP and macromolecules needed for cell growth, division and survival in many cancer types. However, metabolic heterogeneity poses a challenge for the establish
Externí odkaz:
https://doaj.org/article/5ee87f2e4d2940b8b93038a46caacafd
An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial adaptations support the metastasis and chemoresistance of cancer cells. This highlights mitochondria as a promising target for new anticancer strategies. Emergent e
Externí odkaz:
https://doaj.org/article/6dba963cdccf4777ae15048caf9d8cfc
Autor:
Cristina Cueto-Ureña, Enric Mocholí, Josep Escrivá-Fernández, Susana González-Granero, Sabina Sánchez-Hernández, Amalia Solana-Orts, Begoña Ballester-Lurbe, Karim Benabdellah, Rosa M. Guasch, José Manuel García-Verdugo, Francisco Martín, Paul J. Coffer, Ignacio Pérez-Roger, Enric Poch
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Autophagy is a highly conserved process that mediates the targeting and degradation of intracellular components to lysosomes, contributing to the maintenance of cellular homeostasis and to obtaining energy, which ensures viability under stress condit
Externí odkaz:
https://doaj.org/article/7de0449f54f5452689bd32359d3d685e
Autor:
David R. L. Robinson, Daniella H. Hock, Linden Muellner-Wong, Roopasingam Kugapreethan, Boris Reljic, Elliot E. Surgenor, Carlos H. M. Rodrigues, Nikeisha J. Caruana, David A. Stroud
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Mitochondria are complex organelles containing 13 proteins encoded by mitochondrial DNA and over 1,000 proteins encoded on nuclear DNA. Many mitochondrial proteins are associated with the inner or outer mitochondrial membranes, either peripherally or
Externí odkaz:
https://doaj.org/article/74618a07470a4df0adafe985172be429
Autor:
Félix A. Urra, Sebastián Fuentes-Retamal, Charlotte Palominos, Yarcely A. Rodríguez-Lucart, Camila López-Torres, Ramiro Araya-Maturana
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The role of metabolism in tumor growth and chemoresistance has received considerable attention, however, the contribution of mitochondrial bioenergetics in migration, invasion, and metastasis is recently being understood. Migrating cancer cells adapt
Externí odkaz:
https://doaj.org/article/91ca909e0a034c0285079caac23358c5
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Mitochondrial DNA (mtDNA) and the dietary macronutrient ratio are known to influence a wide range of phenotypic traits including longevity, fitness and energy production. Commonly mtDNA mutations are posited to be selectively neutral or reduce fitnes
Externí odkaz:
https://doaj.org/article/14936ce996bd45ceaed077186ed29ba6
Autor:
David A. Frank, Isidora Tošić
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fc1e221705a2edcb47149735290583
http://europepmc.org/articles/PMC8569436
http://europepmc.org/articles/PMC8569436