Zobrazeno 1 - 10
of 4 553
pro vyhledávání: '"OXPHOS"'
Autor:
Qiyu Dong, Xiaojie Yin, Shuanglong Fan, Sheng Zhong, Wenxin Yang, Keer Chen, Qian Wang, Xue Ma, Refiloe Laurentinah Mahlatsi, Yanling Yang, Jianxin Lyu, Hezhi Fang, Ya Wang
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Leigh syndrome (LS) is a common mitochondrial disease caused by mutations in both mitochondrial and nuclear genes. Isoleucyl-tRNA synthetase 2 (IARS2) encodes mitochondrial isoleucine-tRNA synthetase, and variants in IARS2 have be
Externí odkaz:
https://doaj.org/article/e0dc0c332a5b4c46a0d697210083b4e3
Autor:
Iresha Subhasinghe, Khawaja Ashfaque Ahmed, Lisanework E. Ayalew, Hemlata Gautam, Shelly Popowich, Ayumi Matsuyama-Kato, Betty Chow-Lockerbie, Suresh K. Tikoo, Philip Griebel, Susantha Gomis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Oligodeoxynucleotides containing CpG motifs (CpG-ODN) can promote antimicrobial immunity in chickens by enriching immune compartments and activating immune cells. Innate memory, or trained immunity, has been demonstrated in humans and mice,
Externí odkaz:
https://doaj.org/article/afe11101d1254218a19debb706f0c963
Autor:
Mariam M. Konaté, Julia Krushkal, Ming-Chung Li, Li Chen, Yuri Kotliarov, Alida Palmisano, Rini Pauly, Qian Xie, P. Mickey Williams, Lisa M. McShane, Yingdong Zhao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background With poor prognosis and high mortality, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Standard of care therapies for PDAC have included gemcitabine for the past three decades, although resistance
Externí odkaz:
https://doaj.org/article/8450290fb1bd45a187afecbd4534732f
Autor:
Indranil Mondal, Neelam Gupta, Vikas Sharma, Chitra Sarkar, Durga Prasad Mishra, Ritu Kulshreshtha
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-20 (2024)
Abstract Background Glioblastoma (GBM) is the most aggressive among the tumors of the central nervous system (CNS), and has a dismal prognosis. Altered metabolism, especially the increased rate of aerobic glycolysis promotes rapid proliferation of GB
Externí odkaz:
https://doaj.org/article/93c10c552ee04815b2479713adaaf3af
Autor:
Darren ZL Mok, Danny JH Tng, Jia Xin Yee, Valerie SY Chew, Christine YL Tham, Justin SG Ooi, Hwee Cheng Tan, Summer L Zhang, Lowell Z Lin, Wy Ching Ng, Lavanya Lakshmi Jeeva, Ramya Murugayee, Kelvin K-K Goh, Tze-Peng Lim, Liang Cui, Yin Bun Cheung, Eugenia Z Ong, Kuan Rong Chan, Eng Eong Ooi, Jenny G Low
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1310-1323 (2024)
Abstract Vaccination has successfully controlled several infectious diseases although better vaccines remain desirable. Host response to vaccination studies have identified correlates of vaccine immunogenicity that could be useful to guide developmen
Externí odkaz:
https://doaj.org/article/90c7121c4d0546eb8018f9ef0e765fd0
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-22 (2024)
Abstract In women who are getting older, the quantity and quality of their follicles or oocytes and decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, and lower quality oocytes. As more women choose t
Externí odkaz:
https://doaj.org/article/abc35b6ea2434f7fa74a5b5fbb669a1e
Autor:
Daniele Sala, Silvia Marchet, Lorenzo Nanetti, Andrea Legati, Caterina Mariotti, Eleonora Lamantea, Daniele Ghezzi, Alessia Catania, Costanza Lamperti
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-9 (2024)
Abstract Background MT-ATP6 is a mitochondrial gene which encodes for the intramembrane subunit 6 (or A) of the mitochondrial ATP synthase, also known asl complex V, which is involved in the last step of oxidative phosphorylation to produce cellular
Externí odkaz:
https://doaj.org/article/482c0fe92b70470496f07304e8f01d82
Publikováno v:
BMC Ophthalmology, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Uveal melanoma (UVM) is a malignant intraocular tumor in adults. Targeting genes related to oxidative phosphorylation (OXPHOS) may play a role in anti-tumor therapy. However, the clinical significance of oxidative phosphorylation
Externí odkaz:
https://doaj.org/article/e7709d8dd868495e9d01ed282232b42d
Autor:
Barbora Orlikova-Boyer, Anne Lorant, Sruthi Reddy Gajulapalli, Claudia Cerella, Michael Schnekenburger, Jin-Young Lee, Ji Yeon Paik, Yejin Lee, David Siegel, David Ross, Byung Woo Han, Thi Kim Yen Nguyen, Christo Christov, Hyoung Jin Kang, Mario Dicato, Marc Diederich
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Background Despite advancements in chronic myeloid leukemia (CML) therapy with tyrosine kinase inhibitors (TKIs), resistance and intolerance remain significant challenges. Leukemia stem cells (LSCs) and TKI-resistant cells rely on altered mi
Externí odkaz:
https://doaj.org/article/5bd22e469361471b8bf8490d4dd2847c
Autor:
Anne P. M. Beerkens, Daan F. Boreel, James A. Nathan, Jiri Neuzil, Gang Cheng, Balaraman Kalyanaraman, Micael Hardy, Gosse J. Adema, Sandra Heskamp, Paul N. Span, Johan Bussink
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Background Hypoxia is a common feature of many solid tumors and causes radiotherapy and immunotherapy resistance. Pharmacological inhibition of oxidative phosphorylation (OXPHOS) has emerged as a therapeutic strategy to reduce hypoxia. Howev
Externí odkaz:
https://doaj.org/article/6158a99077a34dd2a03b9ab6923fa43f