Výsledky vyhledávání - "OVX, ovariectomized"

Genistein and exercise treatment reduced NASH related HDAC3, IL-13 and MMP-12 expressions in ovariectomized rats fed with high fat high fructose diet

Autor: Duangporn Werawatganon, Namthip Witayavanitkul, Prasong Siriviriyakul, Naruemon Klaikeaw, Maneerat Chayanupatkul

Publikováno v: Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine, Vol 11, Iss 6, Pp 503-512 (2021)

Background and aim Genistein (GEN) and exercise (Ex) may be regarded as an alternative treatment for non-alcoholic steatohepatitis (NASH). However, the mechanisms behind their therapeutic effects in NASH are not well-understood. Experimental procedur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5f39590c2fb7e4cc5a27a3e70f22dd
http://europepmc.org/articles/PMC8572705

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Evaluation of La(XT), a novel lanthanide compound, in an OVX rat model of osteoporosis

Autor: Jaweria Syeda, Munawar Ali, Thomas I. Kostelnik, Kishor M. Wasan, David M. L. Cooper, Ahmad N. Al-Dissi, Nima Ashjaee, David M. Weekes, Ellen K. Wasan, Chris Orvig, Jacqueline F. Cawthray, James D. Johnston, Wubin Cheng, Yunyun Di

Publikováno v: Bone Reports, Vol 14, Iss, Pp 100753-(2021)
Bone Reports

Purpose The purpose of this study was to evaluate the efficacy and toxicity of a novel lanthanum compound, La(XT), in an ovariectomized (OVX) rat model of osteoporosis. Methods Twenty-four ovariectomized female Sprague Dawley rats were divided into 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc015a36cf46569d25173d6296b608e
http://www.sciencedirect.com/science/article/pii/S2352187221000085

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Effects of risedronate, alendronate, and minodronate alone or in combination with eldecalcitol on bone mineral density, quality, and strength in ovariectomized rats

Autor: Teppei Ito, Mei Yamada, Hiromi Kimura-Suda, Yuya Kanehira, Hirotaka Wagatsuma, Tetsuo Yano, Daisuke Inoue

Publikováno v: Bone Reports
Bone Reports, Vol 14, Iss, Pp 101061-(2021)

Combination therapy of active vitamin D3 with some bisphosphonates (BPs) has been reported to be clinically beneficial. However, combination therapy of eldecalcitol (ELD) with BP has to date not been validated as to whether it is beneficial in the cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f85061af35b2a268883043107b9e29
http://europepmc.org/articles/PMC8055548

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Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats

Autor: Rogely W. Boyce, Michael S. Ominsky, Kathrin Locher, Ian Pyrah, Scott Taylor, Rong Hu, Efrain Pacheco

Publikováno v: Bone Reports, Vol 8, Iss, Pp 95-103 (2018)
Bone Reports

Inhibition of sclerostin with sclerostin antibody (Scl-Ab) results in stimulation of bone formation on cancellous (Cn), endocortical (Ec), and periosteal (Ps) surfaces in rodents and non-human primates. With long-term dosing of Scl-Ab, the increase i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc1af9e53755cdc92068b41eaed0ec2
http://www.sciencedirect.com/science/article/pii/S2352187218300147

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Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody

Autor: Rogely W. Boyce, Kathrin Locher, Scott Taylor, Ian Pyrah, Nacera Mellal, Danielle L. Brown, Michael S. Ominsky, Melanie Felx

Publikováno v: Bone Reports, Vol 8, Iss, Pp 90-94 (2018)
Bone Reports

Sclerostin antibody (Scl-Ab) stimulates bone formation, which with long-term treatment, attenuates over time. The cellular and molecular mechanisms responsible for the attenuation of bone formation are not well understood, but in aged ovariectomized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c283365fc79c0da6146f00c605168be0
https://doi.org/10.1016/j.bonr.2018.03.001

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miR-21-5p targets SKP2 to reduce osteoclastogenesis in a mouse model of osteoporosis

Autor: Teng Yao, Jianle Wang, Yizhen Huang, Zizheng Chen, Yining Xu, Yute Yang, Pu-tao Yuan, Jianjun Ma, Shuying Shen, Jun Gao, Shasha Yao

Publikováno v: The Journal of Biological Chemistry

Osteoporosis results from an imbalance between bone formation and bone resorption. Traditional drugs for treating osteoporosis are associated with serious side effects, and thus, new treatment methods are required. This study investigated the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5040272b4ec6961b7b9b2630830ffb77
https://doi.org/10.1016/j.jbc.2021.100617

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Calycosin-7-O-β-d-glucopyranoside stimulates osteoblast differentiation through regulating the BMP/WNT signaling pathways

Autor: Xiaofang Hu, Jian Jing, Cheng Xun, Lijuan Sun, Yong Chen, Jichao Liang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 5, Iss 5, Pp 454-460 (2015)
Acta Pharmaceutica Sinica. B

The isoflavone calycosin-7-O-β-d-glucopyranoside (CG) is a principal constituent of Astragalus membranaceus (AR) and has been reported to inhibit osteoclast development in vitro and bone loss in vivo. The aim of this study was to investigate the ost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfa0f11a56392aa4ecf8534aabac2ad
http://www.sciencedirect.com/science/article/pii/S2211383515000921

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Ectodysplasin a pathway contributes to human and murine skin repair

Autor: Clare L, Garcin, Kenneth M, Huttner, Neil, Kirby, Pascal, Schneider, Matthew J, Hardman

Publikováno v: Journal of Investigative Dermatology, vol. 136, no. 5, pp. 1022-1030
The Journal of Investigative Dermatology

The highly conserved ectodysplasin A (EDA)/EDA receptor signaling pathway is critical during development for the formation of skin appendages. Mutations in genes encoding components of the EDA pathway disrupt normal appendage development, leading to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5af18400c986e2659c99ec28f5b05b1d
https://serval.unil.ch/resource/serval:BIB_15714EFF1E73.P001/REF.pdf

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Mechanisms of bone anabolism regulated by statins

Autor: Feng Ruan, Qiang Zheng, Jinfu Wang

Publikováno v: Bioscience Reports, Vol 32, Iss 6 (2012)
Bioscience Reports

Osteoporosis is a common disease in the elderly population. The progress of this disease results in the reduction of bone mass and can increase the incidence of fractures. Drugs presently used clinically can block the aggravation of this disease. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a317cd2e7a94a10ef8ff1ec46d7e637d
https://doi.org/10.1042/bsr20110118

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DHEA supplementation in ovariectomized rats reduces impaired glucose-stimulated insulin secretion induced by a high-fat diet

Autor: Carla Roberta de Oliveira Carvalho, Renato Tadeu Nachbar, Felipe Natali Almeida, Julia H. Goedecke, Joao Paulo Camporez, Ângelo Rafael Carpinelli, Daniel S. Jesus, Katherine Veras

Publikováno v: FEBS Open Bio
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
FEBS Open Bio, Vol 4, Iss C, Pp 141-146 (2014)

Dehydroepiandrosterone (DHEA) and the dehydroepiandrosterone sulfate (DHEA-S) are steroids produced mainly by the adrenal cortex. There is evidence from both human and animal models suggesting beneficial effects of these steroids for obesity, diabete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedf506e56c650950f5ed0a3b5217038

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