Výsledky vyhledávání - "OVEREXPRESSING MICE"

Investigation into the protection of mitochondrial disease pathology by metallothionein overexpression

Autor: Miller, H.C.

PhD (Biochemistry), North-West University, Potchefstroom Campus Mitochondrial diseases (MD), such as Leigh Syndrome (LS), present with severe neurological and muscular phenotypes in patients, but have no known cure and limited treatment options. Base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1399::1e9078945c96bb3a5e32feae5b8fec02
https://hdl.handle.net/10394/36362

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Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease

Publikováno v: Disease models & mechanisms. 10(5):619-631

Parkinson's disease (PD) is a frequent neurodegenerative process in old age. Accumulation and aggregation of the lipid-binding SNARE complex component alpha-synuclein (SNCA) underlies this vulnerability and defines stages of disease progression. Dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::55017ce1c4c854a30ad3c658aad955ee
https://research.rug.nl/en/publications/f75234f3-344a-4238-adce-465ee1c84690

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Akademický článek

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CRF1 but not glucocorticoid receptor antagonists reduce separation-induced distress vocalizations in guinea pig pups and CRF overexpressing mouse pups. A combination study with paroxetine

Autor: Verdouw, P. Monika, van Esterik, Joantine C.J., Peeters, Bernard W.M.M., Millan, Mark J, Groenink, Lucianne, Pharmacology, Afd Pharmacology

Publikováno v: Pharmacology Biochemistry and Behavior, 154, 11. Elsevier

Rationale Given the large number of patients that does not respond sufficiently to currently available treatment for anxiety disorders, there is a need for improved treatment. Objectives We evaluated the anxiolytic effects of corticotropin releasing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8381b81264c32d66d63703797de4d1
https://dspace.library.uu.nl/handle/1874/359076

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Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones

Autor: Yvette Taché, Lixin Wang, Pu-Qing Yuan, Andreas Stengel, Miriam Goebel-Stengel

Publikováno v: Biology of sex differences, vol 8, iss 1
Biology of Sex Differences

Background Corticotropin-releasing factor overexpressing (CRF-OE) male mice showed an inhibited feeding response to a fast, and lower plasma acyl ghrelin and Fos expression in the arcuate nucleus compared to wild-type (WT) mice. We investigated wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea8dc19930a1a8a3bae300d88ea2ea1
https://doi.org/10.1186/s13293-016-0122-6

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Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease

Publikováno v: Disease Models & Mechanisms, Vol 10, Iss 5, Pp 619-631 (2017)
Disease models & mechanisms, 10(5), 619-631. COMPANY OF BIOLOGISTS LTD
Disease models & mechanisms 10(5), 619-631 (2017). doi:10.1242/dmm.028035
Disease Models & Mechanisms

Parkinson's disease (PD) is a frequent neurodegenerative process in old age. Accumulation and aggregation of the lipid-binding SNARE complex component α-synuclein (SNCA) underlies this vulnerability and defines stages of disease progression. Determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00a153c63c1d424b377819a4e97cc4e

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Changes in gene expression with age: metabolism, repair, and signaling

Publikováno v: Pathobiology of Aging & Age Related Diseases

Leber's Hereditary Optic Neuropathy (LHON) is a neurodegenerative mitochondrial disease characterized by retinal ganglionic cell death and eventual loss of central vision. Specific mtDNA mutations in respiratory complex I subunits (ND4/ND6/ND1) codin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6fb7d940d33d9cfc138d2f0fea33d0f
https://pubmed.ncbi.nlm.nih.gov/26725924

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Perioperative elafin for ischaemia-reperfusion injury during coronary artery bypass graft surgery:a randomised-controlled trial

Autor: Kirsteen Goodman, K Oatey, Oliver Wiedow, Shirjel Alam, Steff C Lewis, Colin Stirrat, David E. Newby, C Moore, R Pessotto, Ashma Krishan, Saeed Mirsadraee, Harkess R, Scott Semple, L Milne, Vipin Zamvar, N M Mills, Peter Henriksen, Marc R. Dweck, S Thomas

Publikováno v: Alam, S R, Lewis, S C, Zamvar, V, Pessotto, R, Dweck, M R, Krishan, A, Goodman, K, Oatey, K, Harkess, R, Milne, L, Thomas, S, Mills, N M, Moore, C, Semple, S, Wiedow, O, Stirrat, C, Mirsadraee, S, Newby, D E & Henriksen, P A 2015, ' Perioperative elafin for ischaemia-reperfusion injury during coronary artery bypass graft surgery : a randomised-controlled trial ', Heart, vol. 101, no. 20 . https://doi.org/10.1136/heartjnl-2015-307745
Heart

BACKGROUND: Elafin is a potent endogenous neutrophil elastase inhibitor that protects against myocardial inflammation and injury in preclinical models of ischaemic-reperfusion injury. We investigated whether elafin could inhibit myocardial ischaemia-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8699a806e7439de7703398b8cf4998c0
https://www.pure.ed.ac.uk/ws/files/21495796/Heart_2015_Alam_heartjnl_2015_307745.pdf

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