Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2

Autor: Gl, Hernández, Ov, Volpert, Ma, Iñiguez, Lorenzo E, Martínez-Martínez S, Grau R, Fresno M, Juan Miguel Redondo

Publikováno v: Europe PubMed Central
The Journal of Experimental Medicine

Cyclosporin A (CsA) is an immunosuppressive drug that inhibits the activity of transcription factors of the nuclear factor of activated T cells (NFAT) family, interfering with the induction of cytokines and other inducible genes required for the immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::91881eb8ba4178bfa93f6ec9c757ba72
http://europepmc.org/abstract/med/11238591

Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma.

Autor: Haltom AR; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX., Hassen WE; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX., Hensel J; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX., Kim J; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX., Sugimoto H; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX., Li B; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX., McAndrews KM; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX., Conner MR; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX., Kirtley ML; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX., Luo X; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX.; Department of Bioengineering, Rice University, Houston, TX., Xie B; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL., Volpert OV; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX., Olalekan S; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL., Maltsev N; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL., Basu A; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL., LeBleu VS; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX.; Feinberg School of Medicine & Kellogg School of Management, Northwestern University, Chicago, IL., Kalluri R; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX.; James P. Allison Institute at MD Anderson, Houston, TX.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.; Department of Bioengineering, Rice University, Houston, TX.

Publikováno v: Extracellular vesicle [Extracell Vesicle] 2022 Dec; Vol. 1. Date of Electronic Publication: 2022 Oct 27.

Novel anti-angiogenic PEDF-derived small peptides mitigate choroidal neovascularization.

Autor: Sheibani N; Department of Ophthalmology and Visual Sciences, Biomedical Engineering, and Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Wang S; Department of Ophthalmology and Visual Sciences, Biomedical Engineering, and Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Darjatmoko SR; Department of Ophthalmology and Visual Sciences, Biomedical Engineering, and Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Fisk DL; Department of Ophthalmology and Visual Sciences, Biomedical Engineering, and Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Shahi PK; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Pattnaik BR; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Sorenson CM; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Bhowmick R; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Volpert OV; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Albert DM; Department of Ophthalmology and Visual Sciences, Biomedical Engineering, and Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Melgar-Asensio I; Center for Developmental Therapeutics, Northwestern University, Evanston, IL, USA., Henkin J; Center for Developmental Therapeutics, Northwestern University, Evanston, IL, USA. Electronic address: j-henkin@northwestern.edu.

Publikováno v: Experimental eye research [Exp Eye Res] 2019 Nov; Vol. 188, pp. 107798. Date of Electronic Publication: 2019 Sep 11.

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche.

Autor: Plebanek MP; Department of Urology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Chicago, IL, 60611, USA.; Simpson-Querrey Institute for Bionantechnology in Medicine, 303 E. Superior St, Chicago, IL, 60611, USA., Angeloni NL; Department of Urology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Chicago, IL, 60611, USA.; Simpson-Querrey Institute for Bionantechnology in Medicine, 303 E. Superior St, Chicago, IL, 60611, USA., Vinokour E; Department of Urology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Chicago, IL, 60611, USA., Li J; Department of Urology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Chicago, IL, 60611, USA., Henkin A; The Department for Health and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 45 Carleton St., Cambridge, MA, 02139, USA., Martinez-Marin D; Department of Urology, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX, 79430-6591, USA., Filleur S; Department of Urology, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX, 79430-6591, USA., Bhowmick R; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, 1881 East Rd, Houston, TX, 77054, USA., Henkin J; Chemistry of Life Processes Institute, Northwestern University, 2145 Sheridan Rd, Evanston, IL, 60208, USA., Miller SD; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Chicago, IL, 60611, USA.; Department of Dermatology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Chicago, IL, 60611, USA., Ifergan I; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Chicago, IL, 60611, USA.; Department of Dermatology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Chicago, IL, 60611, USA., Lee Y; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 240 East 38th Street, New York, NY, 10016, USA.; Laura and Isaac Perlmutter Cancer Center, New York University, Langone Medical Center, 160 East 34th Street, New York, NY, 10016, USA., Osman I; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 240 East 38th Street, New York, NY, 10016, USA.; Laura and Isaac Perlmutter Cancer Center, New York University, Langone Medical Center, 160 East 34th Street, New York, NY, 10016, USA., Thaxton CS; Department of Urology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Chicago, IL, 60611, USA.; Simpson-Querrey Institute for Bionantechnology in Medicine, 303 E. Superior St, Chicago, IL, 60611, USA.; Northwestern University International Institute for Nanotechnology, 2145 Sheridan Rd., Evanston, IL, 60208, USA., Volpert OV; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, 1881 East Rd, Houston, TX, 77054, USA. olgavolp@northwestern.edu.

Publikováno v: Nature communications [Nat Commun] 2017 Nov 06; Vol. 8 (1), pp. 1319. Date of Electronic Publication: 2017 Nov 06.

Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention.

Autor: Bridgeman BB; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Wang P; School of Life Sciences and Technology, China Pharmaceutical University, Nanjing 210009, PR China., Ye B; School of Life Sciences and Technology, China Pharmaceutical University, Nanjing 210009, PR China., Pelling JC; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Volpert OV; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Tong X; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Publikováno v: Cellular signalling [Cell Signal] 2016 May; Vol. 28 (5), pp. 460-468. Date of Electronic Publication: 2016 Feb 12.