Zobrazeno 1 - 10
of 33
pro vyhledávání: '"OTS964"'
Autor:
Yuqi Yang, Qiu-Xu Teng, Zhuo-Xun Wu, Jing-Quan Wang, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Ning Ji, Zhe-Sheng Chen
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-6 (2022)
Highlights ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor. Consistently, a simil
Externí odkaz:
https://doaj.org/article/406c24e5b9104f00acdc1bc578a5b053
Autor:
Dalibor Blazek
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 3, Pp n/a-n/a (2023)
Human cyclin‐dependent kinases (CDKs) direct the progression of the cell cycle and transcription. They are deregulated in tumours, and despite their involvement in the regulation of basic cellular processes, many CDKs are promising targets for canc
Externí odkaz:
https://doaj.org/article/53d7107c041044a298ec86ca6d05c615
Autor:
Fatemeh Movahedi, Jie Liu, Bing Sun, Pei Cao, Luyao Sun, Christopher Howard, Wenyi Gu, Zhi Ping Xu
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1488 (2022)
To overcome the severe side effects of cancer chemotherapy, it is vital to develop targeting chemotherapeutic delivery systems with the potent inhibition of tumour growth, angiogenesis, invasion and migration at low drug dosages. For this purpose, we
Externí odkaz:
https://doaj.org/article/57cb2edff20d40738fd940b34bb6d4ad
Autor:
Yuqi Yang, Zhuo-Xun Wu, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Zhe-Sheng Chen, Dong-Hua Yang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
OTS964 is a potent T-LAK cell-originated protein kinase (TOPK) inhibitor. Herein, we investigated the interaction of OTS964 and multidrug resistance (MDR)-associated ATP-binding cassette sub-family G member 2 (ABCG2). The cell viability assay indicat
Externí odkaz:
https://doaj.org/article/23d03bd97c1a41a8b00e27e334278df3
Autor:
Yuqi Yang, Qiu-Xu Teng, Zhuo-Xun Wu, Jing-Quan Wang, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Ning Ji, Zhe-Sheng Chen
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-6 (2022)
Highlights ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor. Consistently, a simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e674fa95a8d5417ed958ce20d8dee172
https://pubmed.ncbi.nlm.nih.gov/35135547
https://pubmed.ncbi.nlm.nih.gov/35135547
Akademický článek
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Publikováno v:
Oncotarget
Glioblastoma resists chemotherapy then recurs as a fatal space-occupying lesion. To improve the prognosis, the issues of chemoresistance and tumor size should be addressed. Glioma stem cell (GSC) populations, a heterogeneous power-law coded populatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e101eedace60378746a57a7653b473
http://europepmc.org/articles/PMC6481323
http://europepmc.org/articles/PMC6481323
Autor:
Dong-Hua Yang, Suresh V. Ambudkar, Sabrina Lusvarghi, Jing-Quan Wang, Zhe-Sheng Chen, Zi-Ning Lei, Yuqi Yang, Zhuo-Xun Wu, Qiu-Xu Teng
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
OTS964 is a potent T-LAK cell-originated protein kinase (TOPK) inhibitor. Herein, we investigated the interaction of OTS964 and multidrug resistance (MDR)-associated ATP-binding cassette sub-family G member 2 (ABCG2). The cell viability assay indicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0a7baafcdcb040acd13c3fb67181d3
Publikováno v:
Oncotarget
Glioblastoma resists chemoradiotherapy, then, recurs to be a fatal space-occupying lesion. The recurrence is caused by re-growing cell populations such as glioma stem cells (GSCs), suggesting that GSC populations should be targeted. This study addres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbc32d4f753e80a67fcd7cd7714f132
https://doi.org/10.18632/oncotarget.23077
https://doi.org/10.18632/oncotarget.23077
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.