Zobrazeno 1 - 10
of 142
pro vyhledávání: '"OSMR"'
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 11, Pp 2513-2521 (2024)
Amyotrophic lateral sclerosis is a neurodegenerative disease, and the molecular mechanism underlying its pathology remains poorly understood. However, inflammation is known to play an important role in the development of this condition. To identify d
Externí odkaz:
https://doaj.org/article/5a80e4b032f74cfe8251ce34d41c838e
Autor:
Marta Melis, Rebecca Marino, Jianmin Tian, Carla Johnson, Rahil Sethi, Michael Oertel, Ira J. Fox, Joseph Locker
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 453-479 (2024)
Background & Aims: HNF4α, a master regulator of liver development and the mature hepatocyte phenotype, is down-regulated in chronic and inflammatory liver disease. We used contemporary transcriptomics and epigenomics to study the cause and effects o
Externí odkaz:
https://doaj.org/article/270e6dc5cdb04a1fb26e7c7fe9fb3567
Autor:
Yizhou Feng, Yuan Yuan, Hongxia Xia, Zhaopeng Wang, Yan Che, Zhefu Hu, Jiangyang Deng, Fangfang Li, Qingqing Wu, Zhouyan Bian, Heng Zhou, Difei Shen, Qizhu Tang
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background Oncostatin M (OSM) is a secreted cytokine of the interleukin (IL)-6 family that induces biological effects by activating functional receptor complexes of the common signal transducing component glycoprotein 130 (gp130) and OSM rec
Externí odkaz:
https://doaj.org/article/694e59a5294c4ff5ad06033fc099e10b
Akademický článek
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Autor:
Yao Li, Xu Yang, Jia-ni Yuan, Rui Lin, Yun-yuan Tian, Yu-xin Li, Yan Zhang, Xu-fang Wang, Yan-hua Xie, Si-wang Wang, Xiao-hui Zheng
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Ilex rotunda Thunb (IR) is a traditional Chinese medicine used for the clinical treatment of gastric ulcers and duodenal ulcers; however, the effect of IR on ulcerative colitis (UC) and its underlying mechanism remains unclear. This study investigate
Externí odkaz:
https://doaj.org/article/412d04f200574877a226208f1854f0ea
Autor:
Yuji Matsumoto, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Yoshihiro Otani, Atsushi Fujimura, Kentaro Fujii, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Nobushige Tsuboi, Keisuke Kaneda, Keigo Makino, Isao Date
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Glioblastoma (GBM) is characterized by extensive tumor cell invasion, angiogenesis, and proliferation. We previously established subclones of GBM cells with distinct invasive phenotypes and identified annexin A2 (ANXA2) as an activator of an
Externí odkaz:
https://doaj.org/article/6c761b1949624b2696f149d55408b8a8
Akademický článek
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Autor:
Danielle van Keulen, Ian D. van Koeverden, Arjan Boltjes, Hans M. G. Princen, Alain J. van Gool, Gert J. de Borst, Folkert W. Asselbergs, Dennie Tempel, Gerard Pasterkamp, Sander W. van der Laan
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background and Aims: Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants in OSM and its receptors, OSMR and LIFR, on overall plaque vulnerability,
Externí odkaz:
https://doaj.org/article/837b221b59624a7b95001e8d55b5ae17
Autor:
Sarah McCollum, Austen Kalivas, Matthew Kirkham, Kaden Kunz, Jeffrey Okojie, Adriene Pavek, Jared Barrott
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 650 (2022)
Synovial sarcoma (SS) is a pediatric muscle cancer that primarily affects adolescents and young adults and has few treatment options. Complicating the treatment of synovial sarcoma is the low mutational burden of SS. Inflammatory pathways have been i
Externí odkaz:
https://doaj.org/article/afbb489a36f44d05af17dd6c3fece86b
Akademický článek
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