Zobrazeno 1 - 10
of 158
pro vyhledávání: '"OSAMU NAKAJIMA"'
Autor:
Takeru Akabane, Hiromori Sagae, Koen van Wijk, Shinichi Saitoh, Tomohiro Kimura, Satoshi Okano, Ken Kodama, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Michiaki Takagi, Osamu Nakajima
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Heme serves as a prosthetic group in hemoproteins, including subunits of the mammalian mitochondrial electron transfer chain. The first enzyme in vertebrate heme biosynthesis, 5-aminolevulinic acid synthase 1 (ALAS1), is ubiquitously express
Externí odkaz:
https://doaj.org/article/53a9e544ddb14ada9afd52a964b9cb31
Autor:
Michihiro Suwa, Isao Morii, Masaya Kino, Yumie Matsui, Masahiro Yoshinaga, Hiroki Takahashi, Masahiko Takagi, Akira Yoshida, Minoru Ichikawa, Osamu Nakajima, Mitsuhiro Tanimura, Hisashi Shimoyama, Hiroyuki Saitoh, Isao Sasaki, Takeshi Suzuki, Satoshi Uemae
Publikováno v:
Pharmaceuticals, Vol 17, Iss 11, p 1431 (2024)
Background: The therapeutic effects of oral anticoagulant drugs for nonvalvular atrial fibrillation (NVAF) suggest that the three factor Xa (FXa) inhibitors may have distinct safety profiles, though this is not yet fully conclusive. This study invest
Externí odkaz:
https://doaj.org/article/a58064e4ed8742f4868d9983ecfc612b
Autor:
Keiji Minakawa, Tetsuro Yokokawa, Koki Ueda, Osamu Nakajima, Tomofumi Misaka, Yusuke Kimishima, Kento Wada, Yusuke Tomita, Saori Miura, Yuka Sato, Kosaku Mimura, Koichi Sugimoto, Kazuhiko Nakazato, Kenneth E. Nollet, Kazuei Ogawa, Takayuki Ikezoe, Yuko Hashimoto, Yasuchika Takeishi, Kazuhiko Ikeda
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Frameshifts in the Calreticulin (CALR) exon 9 provide a recurrent driver mutation of essential thrombocythemia (ET) and primary myelofibrosis among myeloproliferative neoplasms (MPNs). Here, we generated knock-in mice with murine Calr exon 9
Externí odkaz:
https://doaj.org/article/a52a446c0dda4a20af5f7f461b6cd565
Autor:
Tomoki Bo, Sho Kobayashi, Osamu Inanami, Junichi Fujii, Osamu Nakajima, Tsunekata Ito, Hironobu Yasui
Publikováno v:
Translational Oncology, Vol 14, Iss 11, Pp 101212- (2021)
L-type amino acid transporter 1 (LAT1) is important for transporting neutral amino acids into cells. LAT1 expression is correlated with cancer malignancy, suggesting that LAT1 is a promising target for cancer therapy. JPH203, a potential novel drug t
Externí odkaz:
https://doaj.org/article/2b874841681c4b269ee36071d16dabfa
Autor:
Satoshi Okano, Akira Yasui, Shin-ichiro Kanno, Kennichi Satoh, Masahiko Igarashi, Osamu Nakajima
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Our earlier studies demonstrated that cysteine414- (zinc-binding site of mCRY1-) alanine mutant mCRY1 transgenic mice (Tg mice) exhibit diabetes characterized by the reduction of β-cell proliferation and by β-cell dysfunction, presumably caused by
Externí odkaz:
https://doaj.org/article/ba38f06fd21e400a953dfcc0bb1362f1
Autor:
Shinichi Saitoh, Satoshi Okano, Hidekazu Nohara, Hiroshi Nakano, Nobuyuki Shirasawa, Akira Naito, Masayuki Yamamoto, Vincent P Kelly, Kiwamu Takahashi, Tohru Tanaka, Motowo Nakajima, Osamu Nakajima
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0189593 (2018)
In vertebrates, the initial step in heme biosynthesis is the production of 5-aminolevulinic acid (ALA) by ALA synthase (ALAS). ALA formation is believed to be the rate-limiting step for cellular heme production. Recently, several cohort studies have
Externí odkaz:
https://doaj.org/article/efc895c4df474e859b68c6e39f1d1f91
Autor:
Yoichiro Otaki, Hiroki Takahashi, Tetsu Watanabe, Akira Funayama, Shunsuke Netsu, Yuki Honda, Taro Narumi, Shinpei Kadowaki, Hiromasa Hasegawa, Shintaro Honda, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Hideaki Kamata, Osamu Nakajima, Isao Kubota
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundThe homologous to the E6‐AP carboxyl terminus (HECT)–type ubiquitin E3 ligase ITCH is an enzyme that plays a pivotal role in posttranslational modification by ubiquitin proteasomal protein degradation. Thioredoxin‐interacting protein
Externí odkaz:
https://doaj.org/article/d11826b68e6c43de83028b33860a367c
Autor:
Michiko Sato-Nishiwaki, Yasuko Aida, Shuichi Abe, Yoko Shibata, Tomomi Kimura, Keiko Yamauchi, Hiroyuki Kishi, Akira Igarashi, Sumito Inoue, Masamichi Sato, Osamu Nakajima, Isao Kubota
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73963 (2013)
Alveolar macrophages (AMs) play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We previously demonstrated that the transcription factor, MafB, increased in the AMs of mice exposed to cigarette smoke, and in tho
Externí odkaz:
https://doaj.org/article/8e52454030d84f77ad998791e6db5cc0
Autor:
Toru Saito, Ken Okamura, Rika Kosaki, Kazumasa Wakamatsu, Shosuke Ito, Osamu Nakajima, Hidetoshi Yamashita, Yutaka Hozumi, Tamio Suzuki
Publikováno v:
Pigment Cell & Melanoma Research. 35:212-219
Oculocutaneous albinism (OCA) 6 is a non-syndromic type of OCA that has distinct ocular symptoms and variable cutaneous hypopigmentation. The causative gene of OCA6 is SLC24A5, which encodes NCKX5, a K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09988df13c7514fe15fe44daae4b7cc9
https://doi.org/10.1111/pcmr.13024
https://doi.org/10.1111/pcmr.13024
Autor:
Yuka Terasaki, Osamu Nakajima, Shouji Kitaguchi, Hitoshi Koito, Ryoko Fujita, Tetsuhisa Kitamura, Ryuji Nohara, Hiroyuki Takenaka, Takashi Yamamoto, Miyuki Okuda, Kotoe Takenaka, Kensuke Takabayashi
Publikováno v:
Clinical Cardiology
Background In Japan, both the prevalence of the elderly and super‐elderly and those of acute heart failure (AHF) have been increasing rapidly. Methods This registry was a prospective multicenter cohort, which enrolled a total of 1253 patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5222f279bea34f43b1567fbf78311c14
https://doi.org/10.1002/clc.23619
https://doi.org/10.1002/clc.23619