Zobrazeno 1 - 10
of 338
pro vyhledávání: '"ORSON W. MOE"'
Autor:
Toshiharu Onodera, May-Yun Wang, Joseph M. Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S. Balzer, Dae-Seok Kim, Xuenan Sun, Yu A. An, Bianca C. Field, Charlotte Lee, Ei-ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M. Kusminski, Ruth Gordillo, Laurent Gautron, Denise K. Marciano, Ming Chang Hu, Shawn C. Burgess, Katalin Susztak, Orson W. Moe, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but its local renal role is un
Externí odkaz:
https://doaj.org/article/6885cd75dd3641e481d840972315e815
Autor:
Silvia Ferrè, Yu-Lun Liu, Joshua W. Lambert, Ronit Katz, Fabiola G. Gianella, David A. Drew, Michael G. Shlipak, Orson W. Moe, Joachim H. Ix, Robert D. Toto, Javier A. Neyra
Publikováno v:
Kidney Medicine, Vol 5, Iss 6, Pp 100634- (2023)
Rationale and Objective: Serum magnesium levels have been inversely yet inconsistently associated with cardiovascular (CV) outcomes. In this study, we examined the association of serum magnesium levels with CV outcomes in the Systolic Blood Pressure
Externí odkaz:
https://doaj.org/article/bb693f4ef1c04a4e8628f6df1154d753
Serum IL-17 levels are higher in critically ill patients with AKI and associated with worse outcomes
Autor:
Jason A. Collett, Victor Ortiz-Soriano, Xilong Li, Alexander H. Flannery, Robert D. Toto, Orson W. Moe, David P. Basile, Javier A. Neyra
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-9 (2022)
Abstract Background Interleukin-17 (IL-17) antagonism in rats reduces the severity and progression of AKI. IL-17-producing circulating T helper-17 (TH17) cells is increased in critically ill patients with AKI indicating that this pathway is also acti
Externí odkaz:
https://doaj.org/article/7e1dfbca955b4bc7b20819cfdf01d435
Publikováno v:
eJHaem, Vol 3, Iss 1, Pp 159-162 (2022)
Abstract Erythropoietin‐stimulating agents (ESAs) have revolutionized anemia treatment in end‐stage renal disease (ESRD), but ESA resistance is increasingly identified. Secondary hyperparathyroidism (SHP) is one cause of ESA resistance. We descri
Externí odkaz:
https://doaj.org/article/fe810029554040b59c88c2681b3b92de
Autor:
Alexander H. Flannery, Victor Ortiz-Soriano, Xilong Li, Fabiola G. Gianella, Robert D. Toto, Orson W. Moe, Prasad Devarajan, Stuart L. Goldstein, Javier A. Neyra
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-8 (2021)
Abstract Background Preliminary studies have suggested that the renin-angiotensin system is activated in critical illness and associated with mortality and kidney outcomes. We sought to assess in a larger, multicenter study the relationship between s
Externí odkaz:
https://doaj.org/article/a916748c93944390b50042431c2bf451
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 7, Pp 531-540 (2021)
ABSTRACT Alpha‐Klotho is a multi‐functional protein essential for maintenance of a myriad of cell functions. αKlotho is a single transmembrane protein with a large extracellular segment consisting of two domains (termed Kl1 and Kl2) which is she
Externí odkaz:
https://doaj.org/article/cab31ac6734a4d9e93b5fc9c82173616
Publikováno v:
Physiological Reports, Vol 9, Iss 13, Pp n/a-n/a (2021)
Abstract Background Animal models have demonstrated an interactive relationship between the epithelial anion exchanger SLC26A6 and transporter NaDC‐1 that regulates citrate and oxalate homeostasis. This relationship is a potential mechanism to prot
Externí odkaz:
https://doaj.org/article/35b5ed30865e4b4888b781a86fe52e4c
Autor:
Alexander H. Flannery, Xilong Li, Natalie L. Delozier, Robert D. Toto, Orson W. Moe, Jerry Yee, Javier A. Neyra
Publikováno v:
Kidney Medicine, Vol 3, Iss 4, Pp 507-514.e1 (2021)
Rationale & Objective: Sepsis-associated acute kidney injury often leads to acute kidney disease (AKD), predisposing patients to long-term complications such as chronic kidney disease (CKD), kidney failure with replacement therapy (KFRT), or mortalit
Externí odkaz:
https://doaj.org/article/be601320240e4b9db02d2875e8d1044f
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 11, Pp 675-687 (2019)
Abstract Alpha‐Klotho (αKlotho), produced by the kidney and selected organs, is essential for tissue maintenance and protection. Homozygous αKlotho‐deficiency leads to premature multi‐organ degeneration and death; heterozygous insufficiency l
Externí odkaz:
https://doaj.org/article/269ae62ef57d4f6abb9e7111bc50e054
Autor:
Javier A. Neyra, Ming-Chang Hu, Abu Minhajuddin, Geoffrey E. Nelson, Syed A. Ahsan, Robert D. Toto, Michael E. Jessen, Orson W. Moe, Amanda A. Fox
Publikováno v:
Kidney International Reports, Vol 4, Iss 8, Pp 1131-1142 (2019)
Background: Cardiac surgery–associated acute kidney injury (AKI) is associated with increased morbidity and mortality. We examined the utility of combining biomarkers of kidney function loss (serum cystatin C) and kidney tubular damage (urine neutr
Externí odkaz:
https://doaj.org/article/7c147e81f23244c489099cf72381517d