Autotransplant with and without induction chemotherapy in older multiple myeloma patients: long-term outcome of a randomized trial

Autor: Christian Straka, Peter Liebisch, Hans Salwender, Burkhard Hennemann, Bernd Metzner, Stefan Knop, Sigrid Adler-Reichel, Christian Gerecke, Hannes Wandt, Martin Bentz, Tim Hendrik Bruemmendorf, Marcus Hentrich, Michael Pfreundschuh, Hans-Heinrich Wolf, Orhan Sezer, Ralf Bargou, Wolfram Jung, Lorenz Trümper, Bernd Hertenstein, Else Heidemann, Helga Bernhard, Nicola Lang, Norbert Frickhofen, Holger Hebart, Ralf Schmidmaier, Andreas Sandermann, Tobias Dechow, Albrecht Reichle, Brigitte Schnabel, Kerstin Schäfer-Eckart, Christian Langer, Martin Gramatzki, Axel Hinke, Bertold Emmerich, Hermann Einsele

Publikováno v: Haematologica, Vol 101, Iss 11 (2016)

Autologous transplantation is controversial for older patients with multiple myeloma. The role of age-adjusted high-dose melphalan and the impact of induction chemotherapy cycles is still unclear. A total of 434 patients aged 60–70 years were rando

Externí odkaz: https://doaj.org/article/8484c26faddc436abed9f7a934ff997e

The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network

Autor: Niels W.C.J. van de Donk, Antonio Palumbo, Hans Erik Johnsen, Monika Engelhardt, Francesca Gay, Henrik Gregersen, Roman Hajek, Martina Kleber, Heinz Ludwig, Gareth Morgan, Pellegrino Musto, Torben Plesner, Orhan Sezer, Evangelos Terpos, Anders Waage, Sonja Zweegman, Hermann Einsele, Pieter Sonneveld, Henk M. Lokhorst

Publikováno v: Haematologica, Vol 99, Iss 6 (2014)

Monoclonal gammopathy of undetermined significance is one of the most common pre-malignant disorders. IgG and IgA monoclonal gammopathy of undetermined significance are precursor conditions of multiple myeloma; light-chain monoclonal gammopathy of un

Externí odkaz: https://doaj.org/article/ba5fd314f5ca44ba8995ee1fea2d03c3

Longitudinal Analysis of Tetanus- and Influenza-Specific IgG Antibodies in Myeloma Patients

Autor: Sebastian Kobold, Tim Luetkens, Britta Marlen Bartels, Yanran Cao, York Hildebrandt, Orhan Sezer, Henrike Reinhard, Julia Templin, Katrin Bartels, Nesrine Lajmi, Friedrich Haag, Carsten Bokemeyer, Nicolaus Kröger, Djordje Atanackovic

Publikováno v: Clinical and Developmental Immunology, Vol 2012 (2012)

Background. Multiple myeloma (MM) and its therapies may induce a severely compromised humoral immunity. We have performed a longitudinal analysis of IgG-antibody responses against influenza virus (FLU) and tetanus toxoid (TT) as surrogate markers for

Externí odkaz: https://doaj.org/article/52c3ade030e34cab8f02a573767cf598

Bortezomib in combination with dexamethasone for patients with relapsed Hodgkin’s lymphoma: results of a prematurely closed phase II study (NCT00148018)

Autor: Sven Trelle, Orhan Sezer, Ralph Naumann, Mathias Rummel, Ulrich Keller, Andreas Engert, Peter Borchmann

Publikováno v: Haematologica, Vol 92, Iss 4 (2007)

We conducted a two-stage phase II study to investigate the activity of bortezomib and dexamethasone in patients with relapsed Hodgkin’s lymphoma. The study was prematurely closed after the first stage with twelve enrolled patients because no respon

Externí odkaz: https://doaj.org/article/688dae4800b64caba468796ab3d134c8

Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group

Autor: Mario Boccadoro, Peter Leif Bergsagel, Noopur Raje, Xavier Leleu, Cristina João, Joseph R. Mikhael, Monika Engelhardt, Brian G.M. Durie, Sarah A. Holstein, Heinz Ludwig, Parameswaran Hari, Gordon Cook, Anders Waage, Maria-Victoria Mateos, Ulf-Henrik Mellqvist, Hareth Nahi, Faith E. Davies, Jian Hou, Angelo Maiolino, Saad Z. Usmani, Nizar J. Bahlis, Wee Joo Chng, Sigurdur Y. Kristinsson, Fernando Leal da Costa, Hartmut Goldschmidt, Evangelos Terpos, Pieter Sonneveld, Dominik Dytfeld, Artur Jurczyszyn, Michele Cavo, Fredrik Schjesvold, Meletios A. Dimopoulos, Jacob P. Laubach, Jesus San Miguel, Kwee Yong, Elena Zamagni, Orhan Sezer, Martin Kaiser, Surbhi Sidana, Vania Hungria, Meral Beksac, Enrique M. Ocio, Nikhil C. Munshi, Kenneth C. Anderson, Katja Weisel, Thierry Facon, Annette Juul Vangsted, Christoph Driessen, Hermann Einsele, Luciano J. Costa, Shaji Kumar, Paul G. Richardson, Philippe Moreau, Jesus G. Berdeja, Roman Hájek, Thomas G. Martin, Sagar Lonial, David H. Vesole, Rafael Fonseca, Suzanne Lentzsch, Eloisa Riva, Simon J. Harrison, Hang Quach, Rachid Baz, S. Vincent Rajkumar, Niels W.C.J. van de Donk, Joan Bladé, Jean-Luc Harousseau, Sonja Zweegman

Publikováno v: Moreau, P, Kumar, S K, San Miguel, J, Davies, F, Zamagni, E, Bahlis, N, Ludwig, H, Mikhael, J, Terpos, E, Schjesvold, F, Martin, T, Yong, K, Durie, B G M, Facon, T, Jurczyszyn, A, Sidana, S, Raje, N, van de Donk, N, Lonial, S, Cavo, M, Kristinsson, S Y, Lentzsch, S, Hajek, R, Anderson, K C, João, C, Einsele, H, Sonneveld, P, Engelhardt, M, Fonseca, R, Vangsted, A, Weisel, K, Baz, R, Hungria, V, Berdeja, J G, Leal da Costa, F, Maiolino, A, Waage, A, Vesole, D H, Ocio, E M, Quach, H, Driessen, C, Bladé, J, Leleu, X, Riva, E, Bergsagel, P L, Hou, J, Chng, W J, Mellqvist, U H, Dytfeld, D, Harousseau, J L, Goldschmidt, H, Laubach, J, Munshi, N C, Gay, F, Beksac, M, Costa, L J, Kaiser, M, Hari, P, Boccadoro, M, Usmani, S Z, Zweegman, S, Holstein, S, Sezer, O, Harrison, S, Nahi, H, Cook, G, Mateos, M V, Rajkumar, S V, Dimopoulos, M A & Richardson, P G 2021, ' Treatment of relapsed and refractory multiple myeloma : recommendations from the International Myeloma Working Group ', The Lancet Oncology, vol. 22, no. 3, pp. e105-e118 . https://doi.org/10.1016/S1470-2045(20)30756-7
The Lancet Oncology, 22(3), e105-e118. Lancet Publishing Group

This Policy Review presents the International Myeloma Working Group's clinical practice recommendations for the treatment of relapsed and refractory multiple myeloma. Based on the results of phase 2 and phase 3 trials, these recommendations are propo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c99da86a5d6bbf2b40b4b619992f7c0
http://hdl.handle.net/2318/1791005