Výsledky vyhledávání - "ORF, Open reading frames"

Clinical laboratory evaluation of COVID-19

Autor: Li Zhang, Shuomin Li, Zhufeng Chen, Wanju Xu, Ma Wanshan, Hao Mingju, Yuanxun Fang, Shi Xiaohong

Publikováno v: Clinica Chimica Acta; International Journal of Clinical Chemistry

COVID-19, caused by SARS-CoV-2, is a highly infectious disease, and clinical laboratory detection has played important roles in its diagnosis and in evaluating progression of the disease. Nucleic acid amplification testing or gene sequencing can serv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e01a08c176cdc8b4a0445df4480e07
https://doi.org/10.1016/j.cca.2021.04.022

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The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities

Autor: Sergio Sabbatani, Debora Sifo, Sirio Fiorino, Maddalena Zippi, Claudio Gallo, Dario de Biase, Edoardo Rasciti, Leonardo Rasciti, Roberto Manfredi, Enrico Giampieri, Ivan Corazza, Paolo Leandri

Publikováno v: The British Journal of Nutrition
British Journal of Nutrition

In December 2019, a novel human-infecting coronavirus, named Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), was recognised to cause a pneumonia epidemic outbreak with different degrees of severity in Wuhan, Hubei Province in China. Si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c692caa4fd8856e698ff8534f430697a
https://doi.org/10.1017/s0007114520002913

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Link between SARS-CoV-2 emissions and airborne concentrations: Closing the gap in understanding

Autor: G. Buonanno, A. Robotto, E. Brizio, L. Morawska, A. Civra, F. Corino, D. Lembo, G. Ficco, L. Stabile

Publikováno v: Journal of Hazardous Materials

The airborne transmission of SARS-CoV-2 remains surprisingly controversial; indeed, health and regulatory authorities still require direct proof of this mode of transmission. To close this gap, we measured the viral load of SARS-CoV-2 of an infected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc5d361e03cc13fdb67e09e0b40ffdd
http://hdl.handle.net/11580/91061

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SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases

Autor: Gonzalo Ferreira, Mariana Guirado, Garth L. Nicolson, Florencia Savio, Axel Santander, Luis Sobrevia

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Biochimica et Biophysica Acta. Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1867(12):166264. ELSEVIER SCIENCE BV

Made available in DSpace on 2022-04-28T19:44:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01 Agencia Nacional de Investigación e Innovación Comisión Sectorial de Investigación Científica Fondo Nacional de Desarrollo Científico y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74138c46cacbe2627e0f4293da6b884d

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A short survey of dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases

Autor: Deepak Shilkar, Venkatesan Jayaprakash, Biswatrish Sarkar, Barij Nayan Sinha, Sheikh Murtuja

Publikováno v: Bioorganic & Medicinal Chemistry

Dengue remains a disease of significant concern, responsible for nearly half of all arthropod-borne disease cases across the globe. Due to the lack of potent and targeted therapeutics, palliative treatment and the adoption of preventive measures rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a675c4389f51048f534e368db1d9f9d4
https://pubmed.ncbi.nlm.nih.gov/34601454

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Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease

Autor: Mahmoud Kandeel, Mohammed Al-Nazawi

Publikováno v: Life Sciences

Aims In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual screening study by of FDA approved drugs datas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec09c9f3f89edcb3db9920ac4c502e9

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Approaching coronavirus disease 2019: Mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2

Autor: Pedro Miguel Lacal, Grazia Graziani, Maria Luisa Barbaccia, Lucia Lisi

Publikováno v: Biochemical Pharmacology

Graphical abstract
On March 11, 2020, the World Health Organization (WHO) declared the severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) a global pandemic. As of July 2020, SARS-CoV-2 has infected more than 14 million people

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f360aa8ab7f316d50cacb98cc206343f
http://hdl.handle.net/2108/256570

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No association between the SARS-CoV-2 variants and mortality rates in the Eastern Mediterranean Region

Autor: Samer A. Kharroubi, Saad Omais, Hassan Zaraket

Publikováno v: Gene

As the novel coronavirus SARS-CoV-2 continues to spread in all countries, there is a growing interest in monitoring and understanding the impact of emerging strains on virus transmission and disease severity. Here, we analyzed SARS-CoV-2 genomic sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f460ee0839fa92e31a74815d51b0cf
https://doi.org/10.1016/j.gene.2021.145843

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Can healthy lifestyle reduce disease progression of Alzheimer’s during a global pandemic of COVID-19?

Autor: Kiran Ali, P. Hemachandra Reddy, Albin John, Harrison Marsh

Publikováno v: Ageing Research Reviews

The novel coronavirus disease 2019 (COVID-19) has pushed the medical system to its breaking point. While the virus does not discriminate, the elderly and those with comorbidities, including hypertension severe obesity, diabetes mellitus, coronary dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e115d7400e1873e91a55806af708196c
https://doi.org/10.1016/j.arr.2021.101406

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Targets and strategies for vaccine development against SARS-CoV-2

Autor: Tahmeena Farooqi, Kannan R.R. Rengasamy, Sirajudheen Anwar, Faheem Hyder Pottoo, Jonaid Ahmad Malik, Almas Hanif Mulla

Publikováno v: Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111254-(2021)

Graphical abstract
Highlights • The potential antigen targets are being utilized for the formulation of an effective vaccine. Spike protein is the most utilized antigen target for vaccine development, however other structural and non-structura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ab65f9901da2f7c2301716f0c92c14
https://doi.org/10.1016/j.biopha.2021.111254

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