Zobrazeno 1 - 10
of 33 570
pro vyhledávání: '"OPIOID RECEPTOR"'
Autor:
Haojie Yang, Yangfan Zhang, Zicong Tan, Zihao Liu, Yingzhe Yan, Qin Li, Phei Er Saw, Ning Liufu, Fengtao Ji
Publikováno v:
Discover Nano, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Long noncoding RNAs have emerged as key players in the progression of head and neck squamous cell carcinoma (HNSC). Among them, ZEB1-AS1 was identified as an upregulated candidate in HNSC through comprehensive analysis of RNA-sequencing data
Externí odkaz:
https://doaj.org/article/7b983d163dee4c27ac9754dcd9e9b3af
Publikováno v:
BMC Nephrology, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Difelikefalin is a selective kappa opioid receptor agonist that is approved for the treatment of moderate-to-severe pruritus associated with chronic kidney disease in adults undergoing hemodialysis (HD). In this study, we assessed
Externí odkaz:
https://doaj.org/article/deec51e12f794809baa5fbf35205aee0
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Diviner’s sage (Salvia divinorum; Lamiaceae) is the source of the powerful hallucinogen salvinorin A (SalA). This neoclerodane diterpenoid is an agonist of the human Κ-opioid receptor with potential medical applications in the
Externí odkaz:
https://doaj.org/article/acef4c1fb64d41e6b9f03b7720e66129
Autor:
Yoshihisa UENOYAMA, Miku NONOGAKI, Hitomi TSUCHIDA, Marina TAKIZAWA, Sena MATSUZAKI, Naoko INOUE, Hiroko TSUKAMURA
Publikováno v:
The Journal of Reproduction and Development, Vol 70, Iss 5, Pp 327-337 (2024)
In mammals, secretion of tonic (pulsatile) gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) is often suppressed during lactation. Suppression of GnRH/LH pulses in lactating dams is assumed to be caused by suckling stimuli and a chronic
Externí odkaz:
https://doaj.org/article/1de02d5e56d340ed8d509f7bff937d8b
Autor:
Ruying Zou, Daisuke Nishizawa, Rie Inoue, Junko Hasegawa, Yuko Ebata, Kyoko Nakayama, Atsuko Hara, Hiroyuki Sumikura, Mari Kitade, Masakazu Hayashida, Kazutaka Ikeda, Izumi Kawagoe
Publikováno v:
Neuropsychopharmacology Reports, Vol 44, Iss 3, Pp 650-657 (2024)
Abstract Aim Abundant data are available on the effect of the A118G (rs1799971) single‐nucleotide polymorphism (SNP) of the μ‐opioid receptor OPRM1 gene on morphine and fentanyl requirements for pain control. However, data on the effect of this
Externí odkaz:
https://doaj.org/article/74d643f852724dc89c2c68eb503bbc72
Autor:
Fulei Gu, Yuxuan Zhou, Lili Tian, Jinyan Chen, Can Zhang, Zhangxiang Huang, Weifeng Yu, Kangjie Xie
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Morphine has been suggested to affect cancer cell dynamics and decrease survival rates in lung cancer patients at specific doses, but the precise mechanisms poorly understood. In this study, we aimed to investigate the molecular mechanisms b
Externí odkaz:
https://doaj.org/article/459e86e9d8024314897e6cd9aae14976
Autor:
Hayato Yokota, Yumiko Akamine, Mizuki Kobayashi, Takuro Kitabayashi, Misato Horie, Tentaro Endo, Takechiyo Yamada, Masafumi Kikuchi
Publikováno v:
Journal of Pharmaceutical Health Care and Sciences, Vol 10, Iss 1, Pp 1-6 (2024)
Abstract Background Naldemedine is an orally available peripherally acting μ-opioid receptor antagonist approved to treat opioid-induced constipation (OIC). It is contraindicated for patients with known or suspected gastrointestinal obstruction to p
Externí odkaz:
https://doaj.org/article/67ae06cdfc84401493f0fa958bd84671
Autor:
Sophia C. Levis, Matthew T. Birnie, Yiyan Xie, Noriko Kamei, Puja V. Kulkarni, Johanna S. Montesinos, Christina R. Perrone, Catherine M. Cahill, Tallie Z. Baram, Stephen V. Mahler
Publikováno v:
Addiction Neuroscience, Vol 13, Iss , Pp 100175- (2024)
Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in females, but
Externí odkaz:
https://doaj.org/article/8d64dd9956d94e94af54816248959924
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
Chronic alcohol consumption may alter mRNA methylation and expression levels of genes related to addiction and reward in the brain, potentially contributing to alcohol tolerance and dependence. Neuron-like (SH-SY5Y) and non-neuronal (SW620) cells wer
Externí odkaz:
https://doaj.org/article/11bdb85898814fce9515f930437d368e
Autor:
Boshra Hashemi, Sajad Fakhri, Amir Kiani, Fatemeh Abbaszadeh, Shahram Miraghaee, Mohammad Mohammadi, Javier Echeverría
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionNeuropathic pain is a debilitating neurological disorder and is on the rise. Since no effective treatment has been so far approved to combat the complex pathological mechanisms behind neuropathic pain, finding new therapeutic candidates i
Externí odkaz:
https://doaj.org/article/647a04716d794e4ab807ac81428825ca