Zobrazeno 1 - 10
of 53
pro vyhledávání: '"ONISHA PATEL"'
Autor:
Michael J. Roy, Minglyanna G. Surudoi, Ashleigh Kropp, Jianmei Hou, Weiwen Dai, Joshua M. Hardy, Lung-Yu Liang, Thomas R. Cotton, Bernhard C. Lechtenberg, Toby A. Dite, Xiuquan Ma, Roger J. Daly, Onisha Patel, Isabelle S. Lucet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their expression level is associated with several aggressive c
Externí odkaz:
https://doaj.org/article/5b2aa666db0e4b438310eae34e24f33b
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Patel et al. report crystal structures of the kinase domain of Doublecortin-like kinase 1 (DCLK1) in complex with a potent inhibitor and its precursors. Their structural study reveals insights into the mode of action of the inhibitor DCLK1-IN-1 and s
Externí odkaz:
https://doaj.org/article/6b6a664c847645569a2bc4e72fd9c9cb
Autor:
Catarina F. Almeida, Srinivasan Sundararaj, Jérôme Le Nours, T. Praveena, Benjamin Cao, Satvika Burugupalli, Dylan G. M. Smith, Onisha Patel, Manfred Brigl, Daniel G. Pellicci, Spencer J. Williams, Adam P. Uldrich, Dale I. Godfrey, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose th
Externí odkaz:
https://doaj.org/article/d1409e5d6e6042d8b4b0882766610142
Autor:
Onisha Patel, Michael D. W. Griffin, Santosh Panjikar, Weiwen Dai, Xiuquan Ma, Howard Chan, Celine Zheng, Ashleigh Kropp, James M. Murphy, Roger J. Daly, Isabelle S. Lucet
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Pseudokinases lack kinase activity, yet they impact cellular physiology through the regulation of bona fide signaling kinases. Here the authors describe the structure of the SgK223 pseudokinase and its adjacent domains, and identify regulatory interf
Externí odkaz:
https://doaj.org/article/3c3bd4fad8f44ebaa6db0fe88d4e53a6
Autor:
Michael J. Roy, Minglyanna G. Surudoi, Ashleigh Kropp, Jianmei Hou, Weiwen Dai, Joshua M. Hardy, Lung-Yu Liang, Thomas R. Cotton, Bernhard C. Lechtenberg, Toby A. Dite, Xiuquan Ma, Roger J. Daly, Onisha Patel, Isabelle S. Lucet
PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their expression level is associated with several aggressive cancers. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::855b7e47889b250122b4a56ef519701a
https://doi.org/10.1101/2022.09.01.506260
https://doi.org/10.1101/2022.09.01.506260
Autor:
Isabelle Lucet, Michael Roy, Minglyanna Surudoi, Ashleigh Kropp, Jianmei Hou, Weiwen Dai, Joshua Hardy, Lung-Yu Liang, Thomas Cotton, Bernhard Lechtenberg, Toby Dite, Xiuquan Ma, Roger Daly, Onisha Patel
PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their expression level is associated with several aggressive cancers. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb82c26ebdfe99f526c80bf943b9a60
https://doi.org/10.21203/rs.3.rs-1906871/v1
https://doi.org/10.21203/rs.3.rs-1906871/v1
Autor:
Onisha, Patel, Minglyanna, Surudoi, Weiwen, Dai, Joshua M, Hardy, Michael J, Roy, Isabelle S, Lucet
Publikováno v:
Methods in enzymology. 667
The PEAK family of pseudokinases, which comprises PEAK1, PEAK2 and PEAK3, are newly identified scaffolds that dynamically assemble oncogenic signaling pathways known to contribute to the development of several aggressive cancers. A striking feature o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0f1e0054917b452ebd590fb270442ef
https://pubmed.ncbi.nlm.nih.gov/35525538
https://pubmed.ncbi.nlm.nih.gov/35525538
Autor:
Shoukat Afshar-Sterle, Annalisa L E Carli, Ryan O’Keefe, Janson Tse, Stefanie Fischer, Alexander I Azimpour, David Baloyan, Lena Elias, Pathum Thilakasiri, Onisha Patel, Fleur M Ferguson, Moritz F Eissmann, Ashwini L Chand, Nathanael S Gray, Rita Busuttil, Alex Boussioutas, Isabelle S Lucet, Matthias Ernst, Michael Buchert
Gastric cancer (GC) is the 3rd leading cause of cancer mortality worldwide, therefore providing novel diagnostic and treatment options is crucial for at risk groups. The serine/threonine kinase doublecortin-like kinase 1 (DCLK1) is a proposed driver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fce80a24fd723044400685850d8b005
https://doi.org/10.1101/2022.04.21.489109
https://doi.org/10.1101/2022.04.21.489109
Autor:
Jianmei Hou, Elizabeth V. Nguyen, Minglyanna Surudoi, Michael J. Roy, Onisha Patel, Isabelle S. Lucet, Xiuquan Ma, Roger J. Daly
Publikováno v:
Sci Signal
The pseudokinase scaffolds PEAK1 and PEAK2 are implicated in cancer cell migration and metastasis. We characterized the regulation and role of the third family member PEAK3 in cell signaling. Similar to PEAK1 and PEAK2, PEAK3 formed both homotypic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5483bb6e0cfd3985c76d24592466b32e
https://doi.org/10.1126/scisignal.abj3554
https://doi.org/10.1126/scisignal.abj3554
Autor:
Isabelle S Lucet, Onisha Patel, Samuel N. Young, M.J. Roy, Minglyanna Surudoi, Laura F. Dagley, Toby A. Dite, James M. Murphy, Christopher R Horne, Peter W. Janes, Jarrod J. Sandow, Jeffrey J. Babon, Lung-Yu Liang
Publikováno v:
Biochemical Journal
EphB6 and EphA10 are two poorly characterised pseudokinase members of the Eph receptor family, which collectively serves as mediators of contact-dependent cell–cell communication to transmit extracellular cues into intracellular signals. As per the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9e5a34b01dce60b7c6552d8f3cadc3
https://pubmed.ncbi.nlm.nih.gov/34431498
https://pubmed.ncbi.nlm.nih.gov/34431498