Zobrazeno 1 - 10
of 1 386
pro vyhledávání: '"OGT"'
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a common and important post-translational modification (PTM) linking O-linked β-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues in proteins. Extensive research indicate
Externí odkaz:
https://doaj.org/article/5a6908ab985f4c6aafbf3b7b00cec22c
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Ubiquitination was considered to be a crucial factor in intrahepatic cholangiocarcinoma (iCCA) development. Herein, we identified Ubiquitin-specific peptidase 8 (USP8) as a key regulator for promoting the tumorigenesis of iCCA cell via stabi
Externí odkaz:
https://doaj.org/article/2d3f94fe66ee4f52a901a72b8fe3f45e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Hypoxia-inducible factor-1 (HIF-1) regulates cell growth, protein translation, metabolic pathways and therefore, has been advocated as a promising biological target for the therapeutic interventions against cancer. In general, hyperactivation of HIF-
Externí odkaz:
https://doaj.org/article/4e84d60b62394b378bc3b6e928507afc
Autor:
Jianwen Chen, Bao Zhao, Hong Dong, Tianliang Li, Xiang Cheng, Wang Gong, Jing Wang, Junran Zhang, Gang Xin, Yanbao Yu, Yu L Lei, Jennifer D Black, Zihai Li, Haitao Wen
Publikováno v:
eLife, Vol 13 (2024)
The O-GlcNAc transferase (OGT) is an essential enzyme that mediates protein O-GlcNAcylation, a unique form of posttranslational modification of many nuclear and cytosolic proteins. Recent studies observed increased OGT and O-GlcNAcylation levels in a
Externí odkaz:
https://doaj.org/article/e8c076eebdab41c1be6de9e8394316f4
Autor:
Wei Deng, Yixuan Chen, Jing Zhang, Jitao Ling, Zhou Xu, Zicheng Zhu, Xiaoyi Tang, Xiao Liu, Deju Zhang, Hong Zhu, Haili Lang, Lieliang Zhang, Fuzhou Hua, Shuchun Yu, Kejian Qian, Peng Yu
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Objective Mild therapeutic hypothermia (MTH) is an important method for perioperative prevention and treatment of myocardial ischemia–reperfusion injury (MIRI). Modifying mitochondrial proteins after protein translation to regulate mitocho
Externí odkaz:
https://doaj.org/article/785902f219594939978aaccfe0ca3f18
Gene and Protein Expression of Placental Nutrient-Stress Sensor Proteins in Fetal Growth Restriction
Autor:
Elizabeth Morgan, Grace Chung, Seokwon Jo, Briana Clifton, Sarah A. Wernimont, Emilyn U. Alejandro
Publikováno v:
Stresses, Vol 4, Iss 2, Pp 308-319 (2024)
Fetal growth restriction (FGR) and low birth weight increase the risk of non-communicable diseases such as type 2 diabetes and heart failure in adulthood. Placental insufficiency is widely considered a major contributor to FGR. Two crucial placental
Externí odkaz:
https://doaj.org/article/222d5b95b1a44f93bac915502c1b38be
Autor:
Abigail O. Ayodele, Brenda Udosen, Olugbenga O. Oluwagbemi, Elijah K. Oladipo, Idowu Omotuyi, Itunuoluwa Isewon, Oyekanmi Nash, Opeyemi Soremekun, Segun Fatumo
Publikováno v:
BMC Research Notes, Vol 17, Iss 1, Pp 1-8 (2024)
Abstract O-GlcNAcylation is a nutrient-sensing post-translational modification process. This cycling process involves two primary proteins: the O-linked N-acetylglucosamine transferase (OGT) catalysing the addition, and the glycoside hydrolase OGA (O
Externí odkaz:
https://doaj.org/article/56cb4c8f63d44d858035d2fcf0a42d07
Autor:
Samuel S. Boyd, Dakota R. Robarts, Khue Nguyen, Maite Villar, Ibtihal M. Alghusen, Manasi Kotulkar, Aspin Denson, Halyna Fedosyuk, Stephen A. Whelan, Norman C.Y. Lee, John Hanover, Wagner B. Dias, Ee Phie Tan, Steven R. McGreal, Antonio Artigues, Russell H. Swerdlow, Jeffrey A. Thompson, Udayan Apte, Chad Slawson
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102060- (2024)
Objective: Pharmacologic or genetic manipulation of O-GlcNAcylation, an intracellular, single sugar post-translational modification, are difficult to interpret due to the pleotropic nature of O-GlcNAc and the vast signaling pathways it regulates. Met
Externí odkaz:
https://doaj.org/article/31c888e58b7d4df9804ebed3402bf348
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
AbstractBackgrounds The role of O-GlcNAc transferase (OGT)-induced O-linked N-acetylglucosaminylation (O-GlcNAcylation) has been reported in multiple human diseases. However, its specific functions in osteoarthritis (OA) progression remain undetermin
Externí odkaz:
https://doaj.org/article/11f35befe564428e9fd408f6dc153f53