Zobrazeno 1 - 10
of 494
pro vyhledávání: '"OGA"'
Autor:
Samuel S. Boyd, Dakota R. Robarts, Khue Nguyen, Maite Villar, Ibtihal M. Alghusen, Manasi Kotulkar, Aspin Denson, Halyna Fedosyuk, Stephen A. Whelan, Norman C.Y. Lee, John Hanover, Wagner B. Dias, Ee Phie Tan, Steven R. McGreal, Antonio Artigues, Russell H. Swerdlow, Jeffrey A. Thompson, Udayan Apte, Chad Slawson
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102060- (2024)
Objective: Pharmacologic or genetic manipulation of O-GlcNAcylation, an intracellular, single sugar post-translational modification, are difficult to interpret due to the pleotropic nature of O-GlcNAc and the vast signaling pathways it regulates. Met
Externí odkaz:
https://doaj.org/article/31c888e58b7d4df9804ebed3402bf348
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100195- (2024)
O-GlcNAcylation is a critical post-translational modification involving the addition of N-acetylglucosamine to serine/threonine residues on proteins, significantly influencing their function and stability. In Alzheimer's disease (AD), the modificatio
Externí odkaz:
https://doaj.org/article/c16ba102d80a477f92232b8fa8737663
Autor:
M. Biddle, P. Stylianou, M. Rekas, A. Wright, J. Sousa, D. Ruddy, M. I. Stefana, K. Kmiecik, A. Bandrowski, R.A. Kahn, C. Laflamme, E. M. Krockow, H.S. Virk
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTAntibodies are one of the most important reagents used in biomedical and fundamental research, used to identify, and quantify proteins, contribute to knowledge of disease mechanisms, and validate drug targets. Yet many antibodies used in rese
Externí odkaz:
https://doaj.org/article/37657410713a47738873faec0a812995
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAcute myeloid leukemia (AML) is the most common acute leukemia in adults with an overall poor prognosis and high relapse rate. Multiple factors including genetic abnormalities, differentiation defects and altered cellular metabolism contr
Externí odkaz:
https://doaj.org/article/fb5325fe89af4b1a9b46b685a4c97a0a
Akademický článek
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Publikováno v:
Biomolecules, Vol 14, Iss 8, p 908 (2024)
Post-translational modifications (PTMs) influence protein functionality by modulating protein stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetyla
Externí odkaz:
https://doaj.org/article/30de686b95fa48c19b1d3041a1b69bc2
Publikováno v:
Paradigma: Jurnal Kajian Budaya, Vol 13, Iss 1, Pp 35-48 (2023)
This article report the study of traditional dance in Siguntur Dharmasraya, West Sumatra. Marhasnida, a cultural activist from Nagari Siguntur, created the toga dance. This article explains how the dance was created, developed, and performed from sta
Externí odkaz:
https://doaj.org/article/093bfa15621a43089747c7b66cf75862
Akademický článek
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Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-29 (2022)
Abstract O-linked β-d-N-acetylglucosamine (O-GlcNAc) is an important post-translational modification of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all animals and plants. In eukaryotes, only two conserved e
Externí odkaz:
https://doaj.org/article/5f844bec4e7d41b1a635c3c4b9c5534e