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Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524)

Autor: Nadejda Valiaeva, Payel Chatterjee, Mike Flint, Punya Shrivastava-Ranjan, Robert T. Schooley, James R. Beadle, Karl Y. Hostetler, Joyce Murphy, Christina F. Spiropoulou, Joel M. Montgomery, Michael K. Lo

Publikováno v: Microbiology Spectrum, Vol 9, Iss 3 (2021)
Microbiology Spectrum

The necessity for intravenous administration of remdesivir confines its utility for treatment of coronavirus disease 2019 (COVID-19) to hospitalized patients. We evaluated the broad-spectrum antiviral activity of ODBG-P-RVn, an orally available, lipi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044e908c97c866aaedb083ff3800499c
https://doi.org/10.1101/2021.08.06.455494

Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524).

Autor: Lo MK; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, Georgia, USA., Shrivastava-Ranjan P; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, Georgia, USA., Chatterjee P; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, Georgia, USA., Flint M; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, Georgia, USA., Beadle JR; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA., Valiaeva N; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA., Schooley RT; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA., Hostetler KY; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA., Montgomery JM; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, Georgia, USA., Spiropoulou C; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, Georgia, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Aug 10. Date of Electronic Publication: 2021 Aug 10.

Can changing the prodrug moiety in remdesivir be a life-saving strategy in COVID-19 infection?

Autor: Prabha, Praisy K.¹, Prakash, Ajay², Medhi, Bikash² drbikashus@yahoo.com

Publikováno v: Indian Journal of Medical Research. Jan2023, Vol. 157 Issue 1, p100-103. 4p.

Reshaping Phosphatase Substrate Preference for Controlled Biosynthesis Using a "Design–Build–Test–Learn" Framework.

Autor: Lu, Jiangong^1,2 (AUTHOR), Lv, Xueqin^1,2 (AUTHOR), Yu, Wenwen^1,2 (AUTHOR), Zhang, Jianing^1,2 (AUTHOR), Lu, Jianxing³ (AUTHOR), Liu, Yanfeng^1,2 (AUTHOR), Li, Jianghua² (AUTHOR), Du, Guocheng^1,2 (AUTHOR), Chen, Jian² (AUTHOR), Liu, Long^1,2 (AUTHOR) longliu@jiangnan.edu.cn

Publikováno v: Advanced Science. 6/12/2024, Vol. 11 Issue 22, p1-13. 13p.