Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability

Autor: Mori Y, Yin J, Rashid A, Ba, Leggett, Young J, Lisa Simms, Pm, Kuehl, Langenberg P, Sj, Meltzer, Oc, Stine

Publikováno v: Europe PubMed Central

Coding region frameshift mutation caused by microsatellite instability (MSI) is one mechanism contributing to tumorigenesis in cancers with MSI in high frequency. Mutation of TGFBR2 is one example of this process. To identify additional examples, a l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b9a3737e8954838a953b671eaa7e915e
http://europepmc.org/abstract/med/11507051

Human host status inference from temporal microbiome changes via recurrent neural networks.

Autor: Chen, Xingjian¹ (AUTHOR), Liu, Lingjing¹ (AUTHOR), Zhang, Weitong² (AUTHOR), Yang, Jianyi³ (AUTHOR), Wong, Ka-Chun¹ (AUTHOR) kc.w@cityu.edu.hk

Publikováno v: Briefings in Bioinformatics. Nov2021, Vol. 22 Issue 6, p1-11. 11p.

Neurotoxins and Neurotoxicity Mechanisms. An Overview.

Autor: Segura-Aguilara, Juan¹ jsegura@med.uchile.cl, Kostrzewa, Richard M.²

Publikováno v: Neurotoxicity Research. 2006, Vol. 10 Issue 3/4, p263-285. 23p.

Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries.

Autor: Mishra A; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France., Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Hachiya T; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Jürgenson T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia., Namba S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Posner DC; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Kamanu FK; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Koido M; Division of Molecular Pathology, Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan.; Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Le Grand Q; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France., Shi M; Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., He Y; Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Georgakis MK; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA., Caro I; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France., Krebs K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Liaw YC; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.; Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan., Vaura FC; Department of Internal Medicine, University of Turku, Turku, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Turku, Finland., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Winsvold BS; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway., Srinivasasainagendra V; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Parodi L; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA., Bae HJ; Department of Neurology and Cerebrovascular Disease Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Chauhan G; Rajendra Institute of Medical Sciences, Ranchi, India., Chong MR; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada., Tomppo L; Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Akinyemi R; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Roshchupkin GV; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands., Habib N; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Jee YH; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Thomassen JQ; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Abedi V; Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, VA, USA.; Department of Public Health Sciences, College of Medicine, The Pennsylvania State University, State College, PA, USA., Cárcel-Márquez J; Stroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain., Nygaard M; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Leonard HL; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Yang C; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA., Yonova-Doing E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK., Knol MJ; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands., Lewis AJ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Judy RL; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA., Ago T; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Amouyel P; University of Lille, INSERM U1167, RID-AGE, LabEx DISTALZ, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; CHU Lille, Public Health Department, Lille, France.; Institut Pasteur de Lille, Lille, France., Armstrong ND; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Bakker MK; UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Bartz TM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Bordes C; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France., Børte S; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway., Cain A; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, Saint Louis, MO, USA., Cole JW; VA Maryland Health Care System, Baltimore, MD, USA.; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA., de Jager PL; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA., de Cid R; GenomesForLife-GCAT Lab Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain., Endres M; Klinik und Hochschulambulanz für Neurologie, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Center for Stroke Research Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), partner site Berlin, Berlin, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany., Ferreira LE; Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil., Geerlings MI; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Gasca NC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Hata J; Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., He J; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Heath AK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Ho YL; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Havulinna AS; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland, FIMM-HiLIFE, Helsinki, Finland., Hopewell JC; Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hyacinth HI; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Inouye M; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK., Jacob MA; Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands., Jeon CE; Los Angeles County Department of Public Health, Los Angeles, CA, USA., Jern C; Institute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden., Kamouchi M; Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Keene KL; Department of Biology, Brody School of Medicine Center for Health Disparities, East Carolina University, Greenville, NC, USA., Kitazono T; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Kittner SJ; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Neurology and Geriatric Research and Education Clinical Center, VA Maryland Health Care System, Baltimore, MD, USA., Konuma T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Kumar A; Rajendra Institute of Medical Sciences, Ranchi, India., Lacaze P; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Launer LJ; Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA., Lee KJ; Department of Neurology, Korea University Guro Hospital, Seoul, Republic of Korea., Lepik K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; University Center for Primary Care and Public Health, Lausanne, Switzerland., Li J; Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, VA, USA., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Markus HS; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Marston NA; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Meitinger T; Institute of Human Genetics, Technical University of Munich, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Montellano FA; Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Morisaki T; Division of Molecular Pathology, Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan., Mosley TH; The MIND Center, University of Mississippi Medical Center, Jackson, MS, USA., Nalls MA; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Nordestgaard BG; Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., O'Donnell MJ; College of Medicine Nursing and Health Science, NUI Galway, Galway, Ireland., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.; Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan., Onland-Moret NC; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Ovbiagele B; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Peters A; Institute of Epidemiology, Helmholtz Zentrum München,, German Research Center for Environmental Health, Neuherberg, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilian University Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Munich, Munich, Germany., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Rosand J; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA., Sabatine MS; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sacco RL; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.; Evelyn F. McKnight Brain Institute, Gainesville, FL, USA., Saleheen D; Division of Cardiology, Department of Medicine, Columbia University, New York, NY, USA., Sandset EC; Stroke Unit, Department of Neurology, Oslo University Hospital, Oslo, Norway.; Research and Development, The Norwegian Air Ambulance Foundation, Oslo, Norway., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Sargurupremraj M; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Sasaki M; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Satizabal CL; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Framingham Heart Study, Framingham, MA, USA., Schmidt CO; University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF, Greifswald, Germany., Shimizu A; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA., Sloane KL; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA., Sutoh Y; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Sun YV; Atlanta VA Health Care System, Decatur, GA, USA.; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA., Tanno K; Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan., Tiedt S; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Tatlisumak T; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Unviersity Hospital, Gothenburg, Sweden., Torres-Aguila NP; Stroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain., Tiwari HK; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Trégouët DA; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Tuladhar AM; Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands., Tybjærg-Hansen A; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., van Vugt M; Division Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Vibo R; Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia., Verma SS; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Wennberg P; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Woo D; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Wilson PWF; Atlanta VA Health Care System, Decatur, GA, USA.; Department of Medicine, Division of Cardiovascular Disease, Emory University School of Medicine, Atlanta, GA, USA., Xu H; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Yang Q; Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Yoon K; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Gieger C; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Ninomiya T; Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Rostock, Germany., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands., Rissanen IL; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Strbian D; Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea., Chen PH; Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan., Mayerhofer E; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA., Howson JMM; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Adams H; Department of Clinical Genetics, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.; Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile., Wassertheil-Smoller S; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Christensen K; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands., Rundek T; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.; Evelyn F. McKnight Brain Institute, Gainesville, FL, USA., Worrall BB; Department of Neurology, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Science, University of Virginia, Charlottesville, VA, USA., Lathrop GM; McGill Genome Centre, Montreal, Quebec, Canada., Riaz M; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Simonsick EM; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA., Kõrv J; Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia., França PHC; Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil., Zand R; Geisinger Neuroscience Institute, Geisinger Health System, Danville, PA, USA.; Department of Neurology, College of Medicine, The Pennsylvania State University, State College, PA, USA., Prasad K; Rajendra Institute of Medical Sciences, Ranchi, India., Frikke-Schmidt R; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., de Leeuw FE; Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands., Liman T; Center for Stroke Research Berlin, Berlin, Germany.; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Klinik für Neurologie, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany., Haeusler KG; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Ruigrok YM; UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Heuschmann PU; Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.; Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany.; Clinical Trial Center, University Hospital Würzburg, Würzburg, Germany., Longstreth WT; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Neurology, University of Washington, Seattle, WA, USA., Jung KJ; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea., Bastarache L; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Paré G; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada., Damrauer SM; Department of Surgery and Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Anderson CD; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA.; McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Zwart JA; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Niiranen TJ; Department of Internal Medicine, University of Turku, Turku, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Turku, Finland.; Division of Medicine, Turku University Hospital, Turku, Finland., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Liaw YP; Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan.; Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan., Seshadri S; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Fernández-Cadenas I; Stroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Ruff CT; TIMI Study Group, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Owolabi MO; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Medicine, University of Ibadan, Ibadan, Nigeria., Huffman JE; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Kamatani Y; Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany. Martin.Dichgans@med.uni-muenchen.de.; Munich Cluster for Systems Neurology, Munich, Germany. Martin.Dichgans@med.uni-muenchen.de.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. Martin.Dichgans@med.uni-muenchen.de., Debette S; Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France. stephanie.debette@u-bordeaux.fr.; Department of Neurology, Institute for Neurodegenerative Diseases, CHU de Bordeaux, Bordeaux, France. stephanie.debette@u-bordeaux.fr.

Publikováno v: Nature [Nature] 2022 Dec; Vol. 612 (7938), pp. E7.

General Summary.

Autor: Midei, A, Licinio, J

Publikováno v: Molecular Psychiatry. 2003, Vol. 8 Issue 3, p248. 3p.