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Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs).

Autor: Walji AM; Discovery Chemistry, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Hostetler ED; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Selnick H; Discovery Chemistry, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Zeng Z; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Miller P; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Bennacef I; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Salinas C; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Connolly B; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Gantert L; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Holahan M; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., O'Malley S; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Purcell M; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Riffel K; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Li J; Process Chemistry, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Balsells J; Process Chemistry, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., OBrien JA; Pharmacology, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Melquist S; Pharmacology, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Soriano A; Pharmacology, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Zhang X; Pharmacology, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Ogawa A; Pharmacology, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Xu S; Pharmacology, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Joshi E; Drug Metabolism, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Della Rocca J; Discovery Pharmaceutical Sciences, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Hess FJ; Neuroscience, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Schachter J; Neuroscience, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Hesk D; Labelled Compound Synthesis, Merck & Co., Inc. , Rahway, New Jersey, 07065, United States., Schenk D; Labelled Compound Synthesis, Merck & Co., Inc. , Rahway, New Jersey, 07065, United States., Struyk A; Clinical Pharmacology, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Babaoglu K; Computational Chemistry, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States., Lohith TG; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Wang Y; Pharmaron Beijing Co., Ltd. , Beijing 100176, China., Yang K; Pharmaron Beijing Co., Ltd. , Beijing 100176, China., Fu J; Pharmaron Beijing Co., Ltd. , Beijing 100176, China., Evelhoch JL; Imaging, Merck & Co., Inc. , West Point Pennsylvania 19486, United States., Coleman PJ; Discovery Chemistry, Merck & Co., Inc. , West Point Pennsylvania 19486, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 May 26; Vol. 59 (10), pp. 4778-89. Date of Electronic Publication: 2016 May 05.

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