Zobrazeno 1 - 10
of 52
pro vyhledávání: '"OATP4C1"'
Autor:
Toshihiro Sato, Ayaka Yagi, Minami Yamauchi, Masaki Kumondai, Yu Sato, Masafumi Kikuchi, Masamitsu Maekawa, Hiroaki Yamaguchi, Takaaki Abe, Nariyasu Mano
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 991 (2024)
Flavonoids have garnered attention because of their beneficial bioactivities. However, some flavonoids reportedly interact with drugs via transporters and may induce adverse drug reactions. This study investigated the effects of food ingredients on o
Externí odkaz:
https://doaj.org/article/0497556de20d400491c0339bc4826882
Autor:
Minami Yamauchi, Toshihiro Sato, Ayana Otake, Masaki Kumondai, Yu Sato, Masafumi Kikuchi, Masamitsu Maekawa, Hiroaki Yamaguchi, Takaaki Abe, Nariyasu Mano
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8508 (2022)
Patients with liver diseases not only experience the adverse effects of liver-metabolized drugs, but also the unexpected adverse effects of renally excreted drugs. Bile acids alter the expression of renal drug transporters, however, the direct effect
Externí odkaz:
https://doaj.org/article/5f1063490f6e43cd9bea0a6dabadd820
Akademický článek
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Autor:
Zubida M. Al-Majdoub, Aleksandra Galetin, Jill Barber, Amin Rostami-Hodjegan, Brahim Achour, Daniel Scotcher
Publikováno v:
Al-Majdoub, Z, Scotcher, D, Achour, B, Barber, J, Galetin, A & Rostami-Hodjegan, A 2021, ' Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics ', Clinical Pharmacology & Therapeutics, vol. 110, no. 5, pp. 1389-1400 . https://doi.org/10.1002/cpt.2396
The applications of translational modelling of local drug concentrations in various organs had a sharp increase over the last decade. These are part of the 'Model-Informed Drug Development' (MIDD) initiative, adopted by the pharmaceutical industry an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa01788a3a5432ce20891248dbb0c806
https://doi.org/10.1002/cpt.2396
https://doi.org/10.1002/cpt.2396
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
The kidneys are a pair of important organs that excretes endogenous waste and exogenous biological agents from the body. Numerous transporters are involved in the excretion process. The levels of these transporters could affect the pharmacokinetics o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954864f7315da8b677f1c31c3ebf1f4a
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 24 (2021)
Purpose. Remdesivir and its active metabolite are predominantly eliminated via renal route; however, information regarding renal uptake transporters is limited. In the present study, the interaction of remdesivir and its nucleoside analog GS-441524 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acac5c38597902f6094282885c54a60
https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/31813
https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/31813
Publikováno v:
Amino Acids
Elevated plasma concentrations of the uremic toxin asymmetric dimethylarginine (ADMA) and low plasma concentrations of l-homoarginine are independently associated with cardiovascular events and mortality. Key enzymes involved in the homeostasis of bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b1d458381473fc25164d59becf54da
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/22951
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/22951
Autor:
Sumathy Mathialagan, Claire M. Steppan, Thomas Schroeter, A. David Rodrigues, Piyush Bajaj, Sandra J. Engle
Publikováno v:
Drug Metabolism and Disposition. 46:1703-1711
Current in vitro models for identifying nephrotoxins are poorly predictive. We differentiated human pluripotent stem cells (hPSCs) into three-dimensional, multicellular structures containing proximal tubule cells (PTCs) and podocytes and evaluated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925976c90795a8d74bc46ccd42aca2b8
https://doi.org/10.1124/dmd.118.082727
https://doi.org/10.1124/dmd.118.082727
Autor:
Git Chung, Colin D.A. Brown, Joe Bentz, Akshata Yalvigi, Caroline Lee, Michael O'Connor, Adam Lynn, Harma Ellens, Aqsaa Chaudhry
Publikováno v:
Drug Metabolism and Disposition. 46:279-290
It has been previously demonstrated that IC50 values for inhibition of digoxin transport across confluent polarized cell monolayers are system-dependent. Digoxin IC50 data from five laboratories participating in the P-glycoprotein (P-gp) IC50 Initiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30ade2ecaf40d6d7a551308a028b43ea
https://doi.org/10.1124/dmd.117.075606
https://doi.org/10.1124/dmd.117.075606