Zobrazeno 1 - 10
of 40
pro vyhledávání: '"O.A.G.J. van der Houwen"'
Autor:
C. Sluiter, Auke Bult, Willy J. M. Underberg, Ed Hop, J. J. Kettenes-van den Bosch, O.A.G.J. van der Houwen
Publikováno v:
International Journal of Pharmaceutics. 185:227-235
Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity. To assess its chemical stability, a study was carried out in which the effect of pH, temperature, ionic strength and buf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4e5d24e1b1ecb027ed81d3f81825bc
https://doi.org/10.1016/s0378-5173(99)00160-x
https://doi.org/10.1016/s0378-5173(99)00160-x
Autor:
Wim E. Hennink, M.J. van Steenbergen, O.A.G.J. van der Houwen, Nicolaas J. Zuidam, Willy J. M. Underberg, P. Van De Wetering
Publikováno v:
Macromolecules. 31:8063-8068
The hydrolytic stability of poly(2-(dimethylamino)ethyl methacrylate) was investigated and compared with the stability of its monomer 2-(dimethylamino)ethyl methacrylate (DMAEMA), with 2-(dimethylamino)ethyl isobutyrate (DMAEIB), representing the rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0ac9651d0a5b77f4df34eef9ad5ae41
https://doi.org/10.1021/ma980689g
https://doi.org/10.1021/ma980689g
Publikováno v:
International Journal of Pharmaceutics. 155:137-152
In this study we discuss the application of the general models for pH degradation profiles for specific acid, solvent and base catalysis, both in the absence and presence of ligands, and for the general acid and base catalysis, that we have published
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::349cdf5ad7dc3fd85ac61acc1c4c60d9
https://doi.org/10.1016/s0378-5173(97)00156-7
https://doi.org/10.1016/s0378-5173(97)00156-7
Autor:
Willy J. M. Underberg, O.A.G.J. van der Houwen, Otto Bekers, Auke Bult, Jos H. Beijnen, S.C.M. Lubbers
Publikováno v:
International Journal of Pharmaceutics. 112:97-101
The degradation kinetics of LL-D49194α1 were studied over the pH region 1–13. The contribution of the buffering agents to the degradation has been analyzed using appropriate model equations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f2fc10d9f3b738b639b5acd0b1c4164
https://doi.org/10.1016/0378-5173(94)90266-6
https://doi.org/10.1016/0378-5173(94)90266-6
Autor:
Auke Bult, O.A.G.J. van der Houwen, Jan Teeuwsen, Jos H. Beijnen, Otto Bekers, Willy J. M. Underberg
Publikováno v:
International Journal of Pharmaceutics. 105:249-254
The degradation kinetics of 7- N -( p -hydroxyphenyl)mitomycin C in the presence of cyclodextrin have been investigated over the pH region 0.3–11. Degradation mixtures were analysed by means of UV-Vis spectrometry and high-performance liquid chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6428b52fca564b6b1bf0f6a28e61807
https://doi.org/10.1016/0378-5173(94)90109-0
https://doi.org/10.1016/0378-5173(94)90109-0
Autor:
Auke Bult, Jos H. Beijnen, R.M.J. Goossen, Otto Bekers, Willy J. M. Underberg, O.A.G.J. van der Houwen
Publikováno v:
International Journal of Pharmaceutics. 99:73-78
The degradation kinetics of the nitrosourea derivative nimustine has been investigated over the H0/pH region −1 to 11 at 25°C. The stability tests were performed using a stability-indicating high-performance liquid chromatographic assay. The first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29cecbb8686886bed751c35800096755
https://doi.org/10.1016/0378-5173(93)90325-a
https://doi.org/10.1016/0378-5173(93)90325-a
Publikováno v:
International Journal of Pharmaceutics. 89:R5-R7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::652ee88f438137d7386a4af6e0d699ba
https://doi.org/10.1016/0378-5173(93)90312-4
https://doi.org/10.1016/0378-5173(93)90312-4
Publikováno v:
Journal of Chromatography A. 209:393-404
Breakthrough patterns of eluents containing tetrabutylammonium or cetyltrimethylammonium ions (two frequently used ion-pairing agents in high-performance liquid chromatography) have been studied, using reversed-phase columns with octadecyl chains per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d10889a69b2545a04d549e3778d09fd
https://doi.org/10.1016/s0021-9673(00)80607-x
https://doi.org/10.1016/s0021-9673(00)80607-x
Publikováno v:
International Journal of Pharmaceutics. 45:189-196
The degradation kinetics of a new mitomycin derivative, 7-N-(p-hydroxyphenyl)mitomycin C (M-83), have been investigated over the H0/pH region - 1 to 13. Degradation mixtures were analyzed by means of UV-vis spectrophotometry and high-performance liqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::989a5b85bd0960e714a3f1beebc1948a
https://doi.org/10.1016/0378-5173(88)90288-8
https://doi.org/10.1016/0378-5173(88)90288-8
Autor:
H.G. Kerkdijk, Auke Bult, Jos H. Beijnen, Willy J. M. Underberg, J.J.M. Holthuis, A.C.A. Paalman, O.A.G.J. van der Houwen
Publikováno v:
International Journal of Pharmaceutics. 41:169-178
The chemical stability of the anticancer drug etoposide in aqueous solution has been investigated utilizing a stability-indicating reversed-phase high-performance liquid Chromatographie assay with ultraviolet detection. The degradation processes can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d71b81521abff3379e5628ec2e1054
https://doi.org/10.1016/0378-5173(88)90149-4
https://doi.org/10.1016/0378-5173(88)90149-4