Zobrazeno 1 - 10
of 17
pro vyhledávání: '"O. Yu. Grechko"'
Autor:
A. A. Spasov, L. A. Smirnova, O. Yu. Grechko, N. V. Eliseeva, Yu. V. Lifanova, A. I. Rashchenko, O. N. Zhukovskaya, A. S. Morkovnik, V. A. Anisimova
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 9, Iss 2, Pp 149-160 (2021)
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between
Externí odkaz:
https://doaj.org/article/4c0fb6efffa84b93b12c9aa199034531
Autor:
Alexander A. Spasov, O. N. Zhukovskaya, O. Yu. Grechko, V. A. Anisimova, Anatolii S. Morkovnik, A. I. Rashchenko, Smirnova La, Natalya V. Eliseeva, Yu. V. Lifanova
Publikováno v:
Farmaciâ i Farmakologiâ (Pâtigorsk), Vol 9, Iss 2, Pp 149-160 (2021)
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78575cc93b37bd61f30abf15b9e86ee1
https://doi.org/10.19163/2307-9266-2021-9-2-149-160
https://doi.org/10.19163/2307-9266-2021-9-2-149-160
Autor:
Alexander A. Spasov, V. A. Kuznetsova, Denis A. Babkov, Natalya V. Eliseeva, K. A. Gaidukova, O. N. Zhukovskaya, Tat’yana A. Kuz’menko, A. I. Rashchenko, Anatolii S. Morkovnik, O. Yu. Grechko, A. F. Kucheryavenko, O. A. Salaznikova, V. A. Anisimova
Publikováno v:
Pharmaceutical Chemistry Journal. 52:385-391
A series of 2-(4-trifluoromethylphenyl)- and 2-trifluoromethyl-9-dialkylaminoalkylimidazo[1,2-a]benzimidazoles were synthesized for the first time by reacting 2-amino-1-dialkylaminoalkylbenzimidazoles and 2-bromo-1-[(4-trifluoromethyl)phenyl]ethanone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51d3506be801f82a50131f2b7beb3341
https://doi.org/10.1007/s11094-018-1826-1
https://doi.org/10.1007/s11094-018-1826-1
Autor:
Vladimir Poroikov, Alexander A. Spasov, O. Yu. Grechko, P. M. Vasil’ev, K. Yu. Kalitin, V. A. Anisimova, Dmitry Filimonov
Publikováno v:
Pharmaceutical Chemistry Journal. 50:775-780
Anticonvulsive activities of some condensed imidazo[1,2-a]benzimidazole derivatives were predicted using PASS software. Benzimidazoles as a class showed promise as sources of anticonvulsants. Several compounds demonstrated various levels of anticonvu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3123925785b2287891aba3ee45b59a90
https://doi.org/10.1007/s11094-017-1530-6
https://doi.org/10.1007/s11094-017-1530-6
Publikováno v:
Pharmaceutical Chemistry Journal. 50:1-9
This review provides a brief description of the main structural and functional features of the κ opioid receptor, along with the properties of its agonists and the potential for using these in medicine. Of all the opioid receptor subtypes, κ recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acb15b7406fad610b4c37d92e692dabb
https://doi.org/10.1007/s11094-016-1388-z
https://doi.org/10.1007/s11094-016-1388-z
Publikováno v:
Bulletin of Experimental Biology and Medicine. 160:336-339
Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice. Sodium valproate was used as the reference substance. RU-1205 was superior to sodium valproate by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35061b116c8096639f6f67ef9f115fc
https://doi.org/10.1007/s10517-016-3164-1
https://doi.org/10.1007/s10517-016-3164-1
STUDYING THE PHYSICAL DEPENDENCE ON AND TOLERANCE TO THE ANTINOCICEPTIVE EFFECT OF RU-1205 SUBSTANCE
Publikováno v:
Eksperimental'naia i klinicheskaia farmakologiia. 79(4)
We have studied the physical dependence on and tolerance to the analgesic activity of compound RU-1205. It is established that this compound does not cause side effects typical of morphine and butorphanol including the development of withdrawal syndr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a7b8404faeaf7f70b5531d61794689c
https://pubmed.ncbi.nlm.nih.gov/29949697
https://pubmed.ncbi.nlm.nih.gov/29949697
Autor:
V. A. Kuznetsova, T. M. Mitina, N. A. Gurova, N. A. Kolobrodova, Alexander A. Spasov, V. A. Kosolapov, Sophia V. Den’kina, D. S. Yakovlev, Konstantin F. Suzdalev, A. F. Kucheryavenko, D. V. Mal’tsev, O. Yu. Grechko, L. V. Naumenko, M. N. Babakova
Publikováno v:
Pharmaceutical Chemistry Journal. 47:125-129
Opening of the oxirane ring in 1-oxiranylmethylindoles yielded new indole derivatives containing 1,2-amino alcohol residues at the nitrogen atom. Compounds were studied in vitro in relation to various types of pharmacological activity typical of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cbaae75e5c9c16cd8297595507583b1
https://doi.org/10.1007/s11094-013-0909-2
https://doi.org/10.1007/s11094-013-0909-2
Autor:
K. V. Lenskaya, O. A. Salaznikova, Alexander A. Spasov, T. M. Mitina, N. A. Gurova, D. S. Yakovlev, N. A. Kolobrodova, O. Yu. Grechko, V. A. Kosolapov, V. A. Kuznetsova, E. V. Tibir’kova, D. V. Mal’tsev, I. E. Tolpygin, V. A. Anisimova
Publikováno v:
Pharmaceutical Chemistry Journal. 46:647-652
A series of amides of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyl-N-acetic acids were synthesized. Their pharmacological activity was studied. It was established that the synthesized substances possessed antiaggregant pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ab5003de21e15cc0328f0e9436dacc
https://doi.org/10.1007/s11094-013-0862-0
https://doi.org/10.1007/s11094-013-0862-0
Autor:
T. M. Mitina, Alexander A. Spasov, D. S. Yakovlev, Konstantin F. Suzdalev, M. N. Babakova, A. F. Kucheryavenko, N. A. Gurova, N. A. Kolobrodova, V. A. Kosolapov, O. Yu. Grechko, D. V. Mal’tsev, L. V. Naumenko
Publikováno v:
Pharmaceutical Chemistry Journal. 46:584-590
Opening of the five-member ring of indolylmethyleneoxazolones with aliphatic amines was used to synthesize a series of amides of 2-amino-3-indolylacrylic acid. These compounds were studied in vitro in relation to the various types of pharmacological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcb3f071f41917c222c456e9ba873fc3
https://doi.org/10.1007/s11094-013-0851-3
https://doi.org/10.1007/s11094-013-0851-3