Zobrazeno 1 - 10
of 95
pro vyhledávání: '"O. Yu Leplina"'
Publikováno v:
Медицинская иммунология, Vol 26, Iss 5, Pp 1115-1120 (2024)
The T cell immunoglobulin domain and mucin domain-containing molecule-3 (TIM-3), an inhibitory checkpoint receptor, has been identified as a crucial regulator of cellular immune responses. TIM-3 has been discovered as a receptor involved in the negat
Externí odkaz:
https://doaj.org/article/15dbd7e19f9e4b9fa1a0e5151a391f90
Autor:
E. Ya. Shevela, N. G. Bukhtueva, M. A. Tikhonova, O. Yu. Leplina, N. M. Pasman, E. R. Chernykh
Publikováno v:
Медицинская иммунология, Vol 24, Iss 6, Pp 1151-1158 (2022)
In humans circulating monocytes include classical (CD14++CD16- ), intermediate (CD14++CD16+) and non-classical/alternative (CD14+CD16++) monocytes, which in turn can be activated via the classical or alternative pathway. Pregnancy is accompanied by s
Externí odkaz:
https://doaj.org/article/fc07236983f7495f9293f0e4078a9897
Autor:
E. A. Smetanenko, N. A. Khonina, O. Yu. Leplina, M. A. Tikhonova, E. V. Batorov, N. M. Pasman, E. R. Chernykh
Publikováno v:
Бюллетень сибирской медицины, Vol 21, Iss 3, Pp 87-95 (2022)
Background. Inhibitory receptors and their ligands (also called checkpoint molecules) are important feedback regulators of the immune response. However, their role in immunological adaptation during pregnancy remains poorly understood.The aim of the
Externí odkaz:
https://doaj.org/article/2fd2ceed56d547aba059e7aff33b8fa6
Autor:
S. S. Kirikovich, E. V. Levites, E. V. Dolgova, A. S. Proskurina, G. S. Ritter, V. S. Ruzanova, O. Yu. Leplina, E. Ya. Shevela, A. A. Ostanin, T. G. Ryabicheva, S. L. Ryzhikova, Yu. G. Druzhinina, N. A. Varaksin, E. R. Chernykh, S. S. Bogachev
Publikováno v:
Медицинская иммунология, Vol 23, Iss 2, Pp 257-274 (2021)
This article is the second communication in a series of articles devoted to the effects of a domestic preparation of macrophage-activating factor (GcMAF-RF) and assessment of its biological properties. The aim of this work was to study the effect of
Externí odkaz:
https://doaj.org/article/c6c80c8e6fab43748484c2446df904c7
Autor:
E. A. Smetanenko, O. Yu. Leplina, M. A. Tikhonova, N. M. Pasman, A. A. Ostanin, E. R. Chernykh
Publikováno v:
Бюллетень сибирской медицины, Vol 19, Iss 4, Pp 158-166 (2021)
Background. Recent studies demonstrated immunosuppressive properties of vascular endothelial growth factor (VEGF-A) and identified VEGF-A as a key mediator of tumor-induced immunosuppression. Placental growth factor (PlGF) is another member of VEGF f
Externí odkaz:
https://doaj.org/article/49d8fe8c4b1f456eb09c5e0726207447
Autor:
S. A. Morozov, M. A. Tikhonova, N. V. Pronkina, A. A. Shtobbe, O. Yu. Leplina, E. Ya. Shevela, A. A. Ostanin, E. R. Chernykh
Publikováno v:
Медицинская иммунология, Vol 22, Iss 4, Pp 675-684 (2020)
Early prediction for ischemic stroke (IS) outcome is a major challenge since it may help to optimize treatment program and to make it more personalized. Since T cells with regulatory activity are involved in different pathophysiological processes in
Externí odkaz:
https://doaj.org/article/a48a9fb2557841b49aa45f84b2504d8e
Autor:
T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, L. V. Sakhno, A. A. Maximova, А. A. Ostanin, E. R. Chernykh
Publikováno v:
Медицинская иммунология, Vol 22, Iss 2, Pp 269-280 (2020)
Peripheral blood monocytes are heterogeneous CD14+ cell population, some of which also express CD16 molecule. Differences in phenotype between monocyte subpopulations can affect their functional activity, as well as the ability to further differentia
Externí odkaz:
https://doaj.org/article/67743cc930214eb98d803ac198744bed
Autor:
Yu. D. Kurochkina, T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, A. E. Sizikov, A. E. Sulutian, O. A. Chumasova, A. A. Ostanin, E. R. Chernykh
Publikováno v:
Медицинская иммунология, Vol 21, Iss 5, Pp 835-846 (2019)
Dendritic cells (DCs) play a key role in maintaining the peripheral tolerance of lymphocytes to autoantigens. Recovery of immunological tolerance in autoimmune diseases, particularly, in rheumatoid arthritis (RA) is considered a new therapeutic strat
Externí odkaz:
https://doaj.org/article/38cce2508915427fa7747eaaed410dbb
Publikováno v:
Медицинская иммунология, Vol 21, Iss 4, Pp 653-660 (2019)
The immunomodulatory activity of vascular endothelial growth factors (VEGFs) reveals a new role of neoangiogenesis in tumor development. Most of VEGF effects on T cells are mediated through the VEGF-R2 receptors. Placental growth factor (PlGF) belong
Externí odkaz:
https://doaj.org/article/c85851d822a14a219263bda43e1b113b
Autor:
E. R. Chernykh, E. A. Oleynik, O. Yu. Leplina, M. A. Tikhonova, T. V. Tyrinova, N. M. Starostina, A. A. Ostanin
Publikováno v:
Инфекция и иммунитет, Vol 9, Iss 1, Pp 76-86 (2019)
The induction of a strong multi-epitope T-cell response against hepatitis C virus (HCV) plays an important role in eliminating the virus, whereas adoptive response deficiency contributes to chronic and rapid progression of HCV-infection. Since dendri
Externí odkaz:
https://doaj.org/article/0d0bcb113f96406fa1f0cc45c459bf90