Zobrazeno 1 - 10
of 80
pro vyhledávání: '"O. W. McBride"'
Autor:
O. W. McBride, Thomas J. Santoro, Karen B. Avraham, J E Maguire, Kathleen Kelly, Neal G. Copeland, Nancy A. Jenkins
Publikováno v:
Genomics. 30:558-564
The mitogen-induced gene, GEM, encodes a GTP-binding protein that belongs to a new family within the Ras superfamily. The regulated expression pattern of Gem suggests a role for this protein in cellular responses to growth stimulation. To facilitate
Autor:
Keming Lin, Frank J. Gonzalez, B. Podschun, K. D. Schnackerz, O W McBride, H. Yokota, Pedro M. Fernández-Salguero, H. Furuya
Publikováno v:
Scopus-Elsevier
The pig and human dihydropyrimidine dehydrogenase (DPD) cDNAs were cloned and sequenced. The pig enzyme, expressed in Escherichia coli, catalyzed the reduction of uracil, thymine, and 5-fluorouracil with kinetics approximating those published for the
Autor:
Alisa M. Goldstein, K. S. Kearns, O. W. Mcbride, Sherri J. Bale, Allen E. Bale, M. Turner, John G. Compton
Publikováno v:
Journal of Investigative Dermatology. 103:178-181
The nevoid basal cell carcinoma syndrome is an autosomal dominant disorder characterized primarily by multiple basal cell carcinomas, odontogenic keratocysts, and pits of the palms and soles. Tumor deletion studies and linkage analysis in Caucasians
Publikováno v:
Journal of Biological Chemistry. 268:24385-24393
The gadd45 gene is transcriptionally activated through at least two different mechanisms; one following treatment with base-damaging agents such as methylmethane sulfonate and UV radiation and the other following ionizing radiation. To investigate th
Autor:
Kozo Yoneda, Ming Hai Wang, K U Cehrs, William W. Idler, Peter M. Steinert, O W McBride, Daniel Hohl
Publikováno v:
Journal of Biological Chemistry. 267:18060-18066
Loricrin is the major protein component of the cornified cell envelope of terminally differentiated mammalian epidermal (stratum corneum) cells. Using a specific human cDNA clone, we have isolated and characterized the human loricrin gene. We show th
Autor:
Jennifer D. Luethy, Jikyoung Park, O W McBride, Nikki J. Holbrook, Joseph Fargnoli, Albert J. Fornace, M G Wang
Publikováno v:
Gene. 116:259-267
We report the isolation and characterization of the growth a rrest and D NA- d amage-inducible gene, GADD153 , from human cells and show that it is localized in the region 12q13.1-q13.2 on chromosome 12. Comparison of the human gene with the previous
Autor:
Christopher I. Amos, Bernhard P. Korge, Sherri J. Bale, O. W. Mcbride, John G. Compton, Peter M. Steinert, Abangan Dl, John J. DiGiovanna, Santucci Sk, K. S. Kearns
Publikováno v:
Nature Genetics. 1:301-305
We investigated the molecular genetics of epidermolytic hyperkeratosis (EHK), a dominant disorder characterized by epidermal blistering, hyperkeratosis, vacuolar degeneration and clumping of keratin filaments. Based on this pathology, we have exclude
Publikováno v:
Journal of Biological Chemistry. 267:7710-7717
Membrane-associated transglutaminases (TGase1) have recently been found to be common in mammalian cells, but it is not clear whether these derive from the same or different genes. In order to determine the complexity of this system, we have isolated
Autor:
M. A. Papathanasiou, Jay H. Robbins, I. D. Hickson, O W McBride, Albert J. Fornace, Susanna F. Barrett, I Alamo, N. C. K. Kerr
Publikováno v:
Molecular and Cellular Biology. 11:1009-1016
The effect of ionizing radiation on the expression of two DNA-damage-inducible genes, designated gadd45 and gadd153, was examined in cultured human cells. These genes have previously been shown to be strongly and coordinately induced by UV radiation
Publikováno v:
Journal of Biological Chemistry. 265:14922-14931
Nucleolin, a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. To characterize the genomic organization and regulatory sequences of this gene, two overlapping lambda clones containing the human nucleolin g