Výsledky vyhledávání - "O. W. Griffith"

Strategies to reduce side effects of interleukin-2: evaluation of the antihypotensive agent NG-monomethyl-L-arginine

Autor: R G, Kilbourn, G A, Fonseca, L A, Trissel, O W, Griffith

Publikováno v: The cancer journal from Scientific American. 6

The clinical utility of high-dose intravenous recombinant interleukin (IL)-2 therapy is limited by severe toxicity including hypotension, fever, chills, pulmonary edema, and oliguria Hypotension has been previously shown to result from excessive vasc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fffde3f22fd2a9252597f785cd5a9aca
https://pubmed.ncbi.nlm.nih.gov/10685654

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L-arginine binding to nitric-oxide synthase. The role of H-bonds to the nonreactive guanidinium nitrogens

Autor: B R, Babu, C, Frey, O W, Griffith

Publikováno v: The Journal of biological chemistry. 274(36)

Nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to nitric oxide and L-citrulline. Because overproduction of nitric oxide causes tissue damage in neurological, inflammatory, and autoimmune disorders, design of NOS inhibitors has rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cdef7c46811f81e3e56e73f981ca2f01
https://pubmed.ncbi.nlm.nih.gov/10464242

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The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase

Autor: O W, Griffith, R T, Mulcahy

Publikováno v: Advances in enzymology and related areas of molecular biology. 73

The metabolite glutathione fulfills many important and chemically complex roles in protecting cellular components from the deleterious effects of toxic species. GSH combines with hydroxyl radical, peroxynitrite, and hydroperoxides, as well as reactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7d40eecd42cf16d0a16bf3a9cade6f6
https://pubmed.ncbi.nlm.nih.gov/10218110

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N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase

Autor: B R, Babu, O W, Griffith

Publikováno v: The Journal of biological chemistry. 273(15)

Nitric oxide synthase (NOS) catalyzes the NADPH- and O2-dependent conversion of L-arginine to nitric oxide (NO) and citrulline; three isoforms, the neuronal (nNOS), endothelial, and inducible, have been identified. Because overproduction of NO is kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24330e0816da8a658ca5569bd7b9e84b
https://pubmed.ncbi.nlm.nih.gov/9535869

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Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione

Autor: X, Chen, R L, Schecter, O W, Griffith, M A, Hayward, L C, Alpert, G, Batist

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(1)

5-Oxo-L-prolinase (5-OPase) is an enzyme of the gamma-glutamyl cycle involved in the synthesis and metabolism of glutathione (GSH), which is known to protect cells from the cytotoxic effects of chemotherapy and radiation. Previous studies on rats hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44ff118470568baf1f7ab712cdf91ee9
https://pubmed.ncbi.nlm.nih.gov/9516961

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S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo

Autor: K, Narayanan, L, Spack, K, McMillan, R G, Kilbourn, M A, Hayward, B S, Masters, O W, Griffith

Publikováno v: The Journal of biological chemistry. 270(19)

Nitric oxide synthase catalyzes the oxidation of a guanidino nitrogen of L-arginine to nitric oxide with concomitant formation of citrulline. Enzyme activity is inhibited by a variety of N omega-monosubstituted L-arginine analogs including N omega-al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66696df5bf4032ebd1389bbd25284a28
https://pubmed.ncbi.nlm.nih.gov/7538112

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NG-methyl-L-arginine, an inhibitor of nitric oxide formation, acts synergistically with dobutamine to improve cardiovascular performance in endotoxemic dogs

Autor: R G, Kilbourn, D M, Cromeens, F D, Chelly, O W, Griffith

Publikováno v: Critical care medicine. 22(11)

To evaluate the hemodynamic effects of the nitric oxide inhibitor, NG-methyl-L-arginine, and dobutamine during experimental endotoxemia.Prospective, randomized, controlled animal study.University research laboratory.Adult, male mongrel dogs.After cat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89c32189bdd0adc2d1d9817847499b13
https://pubmed.ncbi.nlm.nih.gov/7956289

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L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases

Autor: C, Frey, K, Narayanan, K, McMillan, L, Spack, S S, Gross, B S, Masters, O W, Griffith

Publikováno v: The Journal of biological chemistry. 269(42)

Nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to citrulline and nitric oxide (NO). The enzyme is inhibited by a variety of N omega-monosubstituted L-arginine analogs, and some of these compounds are useful in reversing pathologies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9d5991c00401f68698e806d10db682f
https://pubmed.ncbi.nlm.nih.gov/7523401

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