Zobrazeno 1 - 10 of 24 pro vyhledávání: '"O. V. Tsepaeva"'
1
Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria
Autor: Denis V. Ponomaryov, Timur I. Abdullin, Leysan R. Grigor’eva, Andrey V. Nemtarev, Vladimir F. Mironov, Taliya I. Salikhova, Trinh Dang, Rezeda A. Ishkaeva, O. V. Tsepaeva
Publikováno v: Medicinal Chemistry Research. 30:925-939
Salicylic acid (SA) remains one of the most fruitful natural compounds to generate drug molecules with versatile activities. In this study, effective synthesis of SA and acetylsalicylic acid (ASA) derivatives with a carrier triphenylphoshonium (TPP)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b99354fe0cb999d781fdfe3d46f2e905
https://doi.org/10.1007/s00044-020-02674-6
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2
Synthesis of C(28)-linker derivatives of betulinic acid bearing phosphonate group
Autor: O. V. Tsepaeva, Leysan R. Grigor’eva, A. V. Nemtarev, Vladimir F. Mironov
Publikováno v: Russian Chemical Bulletin. 70:179-182
A convenient method for the synthesis of C(28)-linker derivatives of triterpenoids containing a phosphonate group is presented. The method is based on the reaction of triterpenic acids (using betulinic acid as an example) with O, O-dialkyl-ω-bromoal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa8442d500b0a5202ea06d7d8b1e9305
https://doi.org/10.1007/s11172-021-3074-x
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3
Synthesis, Anticancer, and Antibacterial Activity of Betulinic and Betulonic Acid C-28-Triphenylphosphonium Conjugates with Variable Alkyl Linker Length
Autor: O. V. Tsepaeva, Andrey V. Nemtarev, Vladimir F. Mironov, Leysan R Grigor Eva, Timur I. Abdullin, Taliya I. Salikhova, Svetlana A Khozyainova
Publikováno v: Anti-Cancer Agents in Medicinal Chemistry. 20:286-300
Background: Conjugation of triterpenoids such as betulinic acid 1 with the Triphenylphosphonium (TPP) group is a powerful approach to generating medicinal compounds. Their development proposes structure optimization in respect of availability and act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa1eeeae19776a538eb34f538481d0f
https://doi.org/10.2174/1871520619666191014153554
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4
3,28-Diacetoxylup-20(29)-ene-30-oic Acid and Its ω-Bromoalkyl Esters
Autor: D. V. Ponomaryov, O. V. Tsepaeva, Vladimir F. Mironov, A. V. Nemtarev, L. R. Grigorʼeva, O. I. Gnezdilov, Igor S. Antipin
Publikováno v: Russian Journal of Organic Chemistry. 56:626-630
A convenient procedure has been developed for the synthesis of 3β,28-diacetoxylup-20(29)-en-30-oic acid via oxidation of 3β,28-di-O-acetylbetulin with selenium dioxide in aqueous ethanol on heating, followed by oxidation of 3β,28-diacetoxylup-20(2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f0b539b20957d18e6fc3d3e0d1eca05
https://doi.org/10.1134/s1070428020040107
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5
Synthesis of C-29-phosphonium derivatives of 3,28-diacetoxylup-20(29)-en-30-oic acid
Autor: Igor S. Antipin, A. V. Nemtarev, Vladimir F. Mironov, D. V. Ponomaryov, O. V. Tsepaeva, L. R. Grigor´eva
Publikováno v: Russian Chemical Bulletin. 69:487-491
3β,28-Diacetoxylup-20(29)-en-30-oic acid (obtained via oxidation of betulin diacetate) enters the addition reaction with P—H-phosphonium salts (triarylphosphonium trifluoroacetates) under mild conditions to afford β-carboxyalkylphosphonium salts.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b419b07614734a9ea89697ef964ed686
https://doi.org/10.1007/s11172-020-2787-6
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6
Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties
Autor: Eugenii A Titov, Anna P. Lyubina, Daut R. Islamov, Tatiana N. Pashirova, Andrey V. Nemtarev, I. A. Litvinov, Aidar T. Gubaidullin, O. V. Tsepaeva, Mudaris N Dimukhametov, Alexandra D. Voloshina, Vladimir F. Mironov, Syumbelya K. Amerhanova
Publikováno v: Molecules
Molecules, Vol 26, Iss 6350, p 6350 (2021)
Volume 26
Issue 21
It has been shown for a wide range of epoxy compounds that their interaction with triphenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation of (2-hydroxypropyl)triphenylphosphonium triflates 3 substituted in the 3-p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b992134d235fb95d2c5007adfd902964
http://europepmc.org/articles/PMC8588467
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7
Synthesis of novel mannopyranosyl betulinic acid phosphoniohexyl ester
Autor: Alexandra V. Kundina, Leysan R. Grigor’eva, O. V. Tsepaeva, A. V. Nemtarev, Vladimir F. Mironov
Publikováno v: Mendeleev Communications. 31:110-112
A general approach to lupane monodesmosides containing a C-28 phosphonioalkyl group is based on the initial glycosylation of triterpene acid ω-haloalkyl esters at the C-3 position. The subsequent phosphorylation with triphenylphosphine and deprotect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0f94930d68a08cbe0a813804bd8addc
https://doi.org/10.1016/j.mencom.2021.01.034
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8
Reaction of Methyl (2-Methylidene)-3-oxolup-20(29)-en-28-oate with Dimethyl Trimethylsilyl Phosphite
Autor: Elena V. Kuznetsova, Vladimir F. Mironov, O. V. Tsepaeva, Timur I. Abdullin, A. V. Nemtarev
Publikováno v: Russian Journal of General Chemistry. 88:1944-1947
A method of phosphorylation of pentacyclic triterpenoids derivatives containing an α,β-unsaturated carbonyl fragment in the ring A was described by the example of the reaction of methyl (2-methylidene)-3-oxolup-20(29)-en-28-oate with dimethyl trime
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa39094289d0fd8357bd8b51a05162bf
https://doi.org/10.1134/s1070363218090335
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9
Design, Synthesis, and Cancer Cell Growth Inhibitory Activity of Triphenylphosphonium Derivatives of the Triterpenoid Betulin
Autor: Rezeda A. Akhmadishina, A. V. Nemtarev, Leysan R. Grigor’eva, Hanh Cong, Elena V. Kuznetsova, Timur I. Abdullin, Liliya Eugenevna Ziganshina, O. V. Tsepaeva, Vladimir F. Mironov
Publikováno v: Journal of Natural Products. 80:2232-2239
A series of new triphenylphosphonium (TPP) derivatives of the triterpenoid betulin (1, 3-lup-20(29)-ene-3β,28-diol) have been synthesized and evaluated for cytotoxic effects against human breast cancer (MCF-7), prostate adenocarcinoma (PC-3), vinbla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c867f8cb843c9393fdb2a4bcbbf5d7f
https://doi.org/10.1021/acs.jnatprod.7b00105
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10
Reaction of methyl 2-methylidene-3-oxolup-20(29)-en-28-oate with triphenylphosphonium trifluoromethanesulfonate
Autor: A. V. Nemtarev, O. V. Tsepaeva, Vladimir F. Mironov
Publikováno v: Russian Journal of Organic Chemistry. 53:621-623
Phosphorylation of methyl 2-methylidene-3-oxolup-20(29)-en-28-oate with triphenylphosphonium trifluoromethanesulfonate in methylene chloride at 20°C afforded 90% of a γ-oxoalkylphosphonium salt containing a terpenoid fragment, [28-methoxy-3,28-diox
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9da2fda1e04e652ffe144de9461f3930
https://doi.org/10.1134/s1070428017040212
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