Zobrazeno 1 - 10
of 20
pro vyhledávání: '"O. V. Stasyk"'
Publikováno v:
Біологічні студії, Vol 16, Iss 3, Pp 35-48 (2022)
Background. Neuroblastoma is a malignant tumor of the sympathetic nervous system common in early childhood. Autophagy is manifested in neuroblastoma cells at basal levels, but is often upregulated in cells of the aggressive neuroblastoma forms. The a
Externí odkaz:
https://doaj.org/article/26a39da61b1b4d6bb4154001b4bb5167
Publikováno v:
Біологічні студії, Vol 15, Iss 3, Pp 41-50 (2021)
Background. Improper folding and accumulation of a-synuclein aggregates are among the causes of Parkinson’s disease. The most important factor influencing the process of α-synuclein aggregation is the level of this protein in neurons which depends
Externí odkaz:
https://doaj.org/article/35a65ffece454ee5af734e7481dc705a
Publikováno v:
The Ukrainian Biochemical Journal, Vol 92, Iss 5, Pp 120-133 (2020)
In this study we analyzed how exogenous glucose levels affect enzymatic and non-enzymatic antioxidant defense systems and markers of oxidative stress in cells of the methylotrophic yeast Ogataea polymorpha producing recombinant human α-synuclein, im
Externí odkaz:
https://doaj.org/article/31fab56c3dcd40a0a3f3289b607a6b64
Prooxidant-antioxidant balance in the methylotrophic yeast Ogataea polymorpha exoposed to spermidine
Publikováno v:
Біологічні студії, Vol 14, Iss 3, Pp 13-28 (2020)
Background. Many molecular compounds used by eukaryotic cells as antioxidant agents can directly interact with reactive oxygen/nitrogen species. Among them are polyamines – natural substances with pronounced antioxidant properties. The main polyami
Externí odkaz:
https://doaj.org/article/caaae3c76173424faa6ab50c8be5b893
Autor:
O. I. Vovk, O. I. Chen, N. I. Igumentseva, O. Yu. Senchuk, M. L. Barska, N. O. Sybirna, O. V. Stasyk
Publikováno v:
The Ukrainian Biochemical Journal, Vol 88, Iss 2, Pp 45-55 (2016)
It was previously demonstrated in in vitro experiments that canavanine (Cav), a natural toxic arginine analogue of plant origin, is a promising candidate for augmenting the antineoplastic effects of arginine starvation. We demonstrated herein that re
Externí odkaz:
https://doaj.org/article/56c4bf21e5314be6a05d62c28087c6b1
Autor:
O. I. Chen, М. L. Barska, L. S. Lyniv, N. I. Igumentseva, О. I. Vovk, N. O. Sybirna, O. V. Stasyk
Publikováno v:
Біологічні студії, Vol 10, Iss 1, Pp 17-28 (2016)
Arginine deprivation has been recently suggested as a therapeutic approach against difficult to cure blood cancers. Herein, we investigated for the first time the combined effect of exogenous nitric oxide (NO) donor and recombinant human arginase (rh
Externí odkaz:
https://doaj.org/article/cdb8beed8175436f93ea564159145a7d
Publikováno v:
Біологічні студії, Vol 8, Iss 2, Pp 5-16 (2014)
Abnormal oligomerisation and aggregation of the protein called alpha-synuclein (α-syn) are the key events in the pathogenesis of Parkinson’s disease (PD). Recent discoveries revealed cellular pathways that potentially relate neurodegenerative dise
Externí odkaz:
https://doaj.org/article/d8e5860d179049a393542fd36f3a5994
Publikováno v:
Біологічні студії, Vol 6, Iss 3, Pp 39-54 (2012)
The first and limiting step of metabolism of glucose, the most widespread carbon and energy source for majority of cells, is the transport of this sugar across cytoplasmic membrane. In the eukaryotic cells glucose controls and ensures its own effecti
Externí odkaz:
https://doaj.org/article/bf694bb88d7e40e9afb867d21dd80a44
Publikováno v:
Біологічні студії, Vol 6, Iss 2, Pp 33-44 (2012)
In the yeasts, as in the majority of microorganisms, glucose is the main source of carbon and energy, as well as a key effector molecule involved in transcriptional regulation. Many genes are repressed in the presence of glucose, others are instead i
Externí odkaz:
https://doaj.org/article/5f5e970684a94baea6cf539a3642e536
Publikováno v:
Біологічні студії, Vol 5, Iss 3, Pp 19-28 (2011)
Escherichia coli strain BL21(DE3)/pET42a/ASS – an efficient producer of recombinant human argininosuccinate synthetase (rhASS) – was constructed, and preparations of purified rhASS were obtained using His-tag affinity chromatography. The effect o
Externí odkaz:
https://doaj.org/article/3dcbb00fec8940b88321a07082e92116