Zobrazeno 1 - 4
of 4
pro vyhledávání: '"O. V. Merkushenkova"'
Autor:
O. V. Merkushenkova, V. M. Berestovitskaya, S. M. Aleksandrova, E. S. Ostroglyadov, O. S. Vasil’eva, Ivan N. Tyurenkov, V. V. Bagmetova
Publikováno v:
Pharmaceutical Chemistry Journal. 52:392-396
A series of indole-containing γ-aminobutyric acids (GABA) were synthesized via alkaline hydrolysis of 4-(indol-3-yl)-2-pyrrolidones. Their structures were confirmed by IR, PMR, and 13C NMR spectroscopy. Studies of the pharmacological properties of 4
Autor:
V. B. Narkevich, V. V. Bagmetova, E. A. Kondrakhin, Yu. V. Markina, V. S. Kudrin, O. V. Merkushenkova, P. M. Klodt, E. V. Vasil’eva, G. I. Kovalev, Ivan N. Tyurenkov
Publikováno v:
Neurochemical Journal. 9:20-28
It is known that neuroglutam (at 26 mg/kg) potentiates stereotypy that is induced by the agonist of postsynaptic dopamine receptors apomorphine (1 mg/kg), and suppresses catalepsy that is induced by the blocker of postsynaptic dopamine receptors halo
Publikováno v:
Bulletin of Experimental Biology and Medicine. 158:229-233
β-Phenylglutamic acid hydrochloride (RGPU-135, neuroglutam) in doses of 13-650 mg/kg suppressed depressive behavior of animals in the Porsolt test (i.e. produced antidepressant properties), reduced anxiety in the open-field, elevated plus maze, and
Publikováno v:
Bulletin of experimental biology and medicine. 156(6)
In contrast to L-glutamic acid (200 mg/kg), β-phenylglutamic acid hydrochloride (26 mg/kg) produces no anticonvulsant effects during generalized convulsions induced by “maximum electric shock”. However, β-phenylglutamic acid hydrochloride was m