Výsledky vyhledávání - "O. V. Kotel'nikova"

IgA1 Protease as a Vaccine Basis for Prevention of Bacterial Meningitis

Autor: D. M. Karlinsky, Yu. A. Prokopenko, L. S. Zhigis, A. A. Zinchenko, Lev D. Rumsh, O. V. Kotel’nikova

Publikováno v: Russian Journal of Bioorganic Chemistry. 47:805-814

Abstract The review covers the study of the protective properties of IgA1 protease and the possibility of creating a vaccine preparation for the prevention of bacterial meningitis of various origins on its basis. Bacterial meningitis belongs to the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7eb4e55bc14b1342576fa31351e4d8dd
https://doi.org/10.1134/s106816202104021x

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Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections

Autor: E. A. Nokel, O. V. Kotel’nikova, V. S. Zueva, A. P. Alliluev, Marina Tokarskaya, Natalia Yastrebova, Lev D. Rumsh, O. A. Razgulyaeva, E. I. Gordeeva, T. D. Melikhova, E. N. Kaliberda, L. S. Zhigis, Yuri Prokopenko, A. A. Zinchenko

Publikováno v: Microbes and Infection. 21:336-340

Immunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including N. meningitidis serogroups A, B, and C and 3 serotypes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4f32a070477266af6131c3f3549f4f
https://doi.org/10.1016/j.micinf.2019.02.003

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Peculiarities of the Formation of Antimeningococcus Immunity in Mice Immunized with Fragments of N. meningitidis IgA1 Protease

Autor: Lev D. Rumsh, V. S. Zueva, Yu. A. Prokopenko, A. P. Alliluev, L. S. Zhigis, O. A. Razgulyaeva, A. A. Zinchenko, T. D. Melikhova, O. V. Kotel’nikova, E. A. Nokel, E. A. Gordeeva

Publikováno v: Bulletin of Experimental Biology and Medicine. 165:763-766

We studied immunogenicity of two recombinant proteins FR.9 and FR.11-3 created on the basis of fragments of the primary structure of N. meningitidis IgA1 protease with different molecular weights containing different sets of T and B epitopes. The pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b18cc9f835a46bba0d80ad1a5a3d511
https://doi.org/10.1007/s10517-018-4260-1

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Immunogenic and Protective Properties of Neisseria meningitidis IgA1 Protease and of Its Truncated Fragments

Autor: L. S. Zhigis, V. S. Zueva, Yu. A. Prokopenko, O. V. Kotel’nikova, O. A. Razgulyaeva, A. P. Alliluev, A. A. Zinchenko, E. A. Gordeeva, O. V. Serova, T. D. Melikhova, Lev D. Rumsh, E. A. Nokel

Publikováno v: Russian Journal of Bioorganic Chemistry. 44:64-72

Four recombinant proteins, MA28–P1004LEH6, ME135–H328LEH6, MW329–H622LEH6 and MH835–P1004LEH6, were prepared based on the genomic sequence of IgA1 protease from Neisseria meningitidis serogroup B strain H44/76. The immunogenic and protective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1885904b60f3b2f5e0a7d8011043bf1f
https://doi.org/10.1134/s1068162018010193

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Potential Polyvaccine Based on Microbial IgA1 Protease for Prophylaxis of Bacterial Meningitis

Autor: E. Yu. Drozhzhina, O. V. Kotel’nikova, O. A. Razgulyaeva, Lev D. Rumsh, Yu. A. Prokopenko, A. P. Alliluev, E. A. Nokel, A. A. Zinchenko, T. D. Melikhova, L. S. Zhigis

Publikováno v: Эпидемиология и вакцинопрофилактика, Vol 15, Iss 6, Pp 88-94 (2016)

The immunogenic and protective activities of recombinant IgA1 serine protease obtained on the base of the genome DNA of N. meningitidis serogroup B strain H44/76 were studied. A several recombinant proteins of different molecular weights that are bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637bc70b28d7005bd86c2c278e36a358
https://doi.org/10.31631/2073-3046-2016-15-6-88-94

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Protective properties of recombinant IgA1 protease from meningococcus

Autor: L. S. Zhigis, E. Yu. Yagudaeva, E. Yu. Drozhzhina, E. A. Sitnikova, A. A. Zinchenko, V. S. Zueva, I. S. Koroleva, O. A. Razgulyaeva, T. D. Melikhova, E. A. Nokel, E. A. Gordeeva, A. P. Alliluev, O. V. Kotel’nikova, Lev D. Rumsh, O. V. Serova

Publikováno v: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 7:305-310

The study of enzymatic and protective properties of recombinant IgA1 protease in active and mutant form showed that active form of IgA1 protease exhibited species - and type-specificity for mouse and human immunoglobulins. Mutant form, which did not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a57a6fa6d1f6d14c624b5adae7281e
https://doi.org/10.1134/s1990750813040033

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Isolation and determination of the activity of IgA1 protease from Neisseria meningitidis

Autor: A. P. Alliluev, O. A. Razgulyaeva, A. M. Bichucher, Lev D. Rumsh, O. V. Kotel’nikova, E.E. Melnikov, Vitaly P. Zubov, E. Yu. Yagudaeva, L. S. Zhigis, L. V. Kozlov, V. S. Zueva, A. E. Avakov

Publikováno v: Russian Journal of Bioorganic Chemistry. 36:81-89

A method of the isolation and purification of IgA1 protease from a culture of Neisseria meningitidis serogroup A has been developed. Three inactivated intermediates of the production of the meningococcal vaccine, a culture liquid, as well as a supern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d00d90475c48a88a485bc9bc4fd5315
https://doi.org/10.1134/s1068162010010085

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