Zobrazeno 1 - 6
of 6
pro vyhledávání: '"O. V. Gribovskaya"'
Autor:
O. V. Gribovskaya, V. P. Martinovich, E. V. Rodko, E. D. Rasyuk, T. V. Ryabtseva, V. P. Golubovich
Publikováno v:
Russian Journal of Bioorganic Chemistry. 47:1249-1256
Abstract— It is known that the Arg-Gly-Asp sequence in the fibrinogen molecule is key in binding to the receptors on the surface of platelets. We searched for the compounds which were able to inhibit the binding and synthesized the following analog
Publikováno v:
Doklady of the National Academy of Sciences of Belarus. 65:303-308
Biospecific sorbents for the removal of IgG and subclasses from biological fluids based on oligopeptides, containing aromatic amino acid residues, were created. The selectivity properties of specific sorbents for IgM, IgE, and plasma proteins were ev
Publikováno v:
Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 56:88-95
Hyperproduction of immunoglobulin G (IgG) is a major pathogenic factor in autoimmune diseases. Specific sorbents are used to eliminate the high level of IgG. Molecular docking can be used as a tool for theoretical search for sorbent ligands for the I
Autor:
V. P. Golubovich, V. V. Kirkovskiy, T. V. Ryabtseva, V. P. Martinovich, D. A. Makarevich, O. V. Gribovskaya
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:165-170
Molecular modeling, which identified several peptide sequences, was carried out in search for compounds capable of reducing the interleukin-8 concentration in human blood plasma. The replacement of the glutamic acid residue in the Glu-His-OMe and Glu
Autor:
O. V. Gribovskaya, V. P. Martinovich, V. P. Golubovich, L. R. Vykhristenko, D. K. Novikov, V. V. Yanchenko
Publikováno v:
Russian Journal of Bioorganic Chemistry. 38:253-260
Using computer analysis, a minimal sequence of Arg136-Asn137-Trp138-Asp139 that can bind to IgE C3 and C4 fragments was determined for the high-affinity receptor FcɛRI, a key protein of IgE-dependent allergic reactions of the immediate type. A numbe
Publikováno v:
Biomeditsinskaya Khimiya. 58:211-219
New bioaffine sorbents containing bioselective ligand, synthetic analog of the human thyroperoxidase antigenic determinant - tetrapeptide H-Glu-Gln-βAla-Lys-OMe, immobilized on two polymeric matrixes - a polyacrylamide gel and CNBr-activated sepharo