Transient expression of the neuropeptide galanin modulates peripheral‑to‑central connectivity in the somatosensory thalamus during whisker development in mice

Autor: Zsofia Hevesi, Joanne Bakker, Evgenii O. Tretiakov, Csaba Adori, Anika Raabgrund, Swapnali S. Barde, Martino Caramia, Thomas Krausgruber, Sabrina Ladstätter, Christoph Bock, Tomas Hökfelt, Tibor Harkany

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract The significance of transient neuropeptide expression during postnatal brain development is unknown. Here, we show that galanin expression in the ventrobasal thalamus of infant mice coincides with whisker map development and modulates subcor

Externí odkaz: https://doaj.org/article/d4760fb7c03843a2b760fe128c959522

Secondary structure of the human mitochondrial genome affects formation of deletions

Autor: Victor Shamanskiy, Alina A. Mikhailova, Evgenii O. Tretiakov, Kristina Ushakova, Alina G. Mikhailova, Sergei Oreshkov, Dmitry A. Knorre, Natalia Ree, Jonathan B. Overdevest, Samuel W. Lukowski, Irina Gostimskaya, Valerian Yurov, Chia-Wei Liou, Tsu-Kung Lin, Wolfram S. Kunz, Alexandre Reymond, Ilya Mazunin, Georgii A. Bazykin, Jacques Fellay, Masashi Tanaka, Konstantin Khrapko, Konstantin Gunbin, Konstantin Popadin

Publikováno v: BMC Biology, Vol 21, Iss 1, Pp 1-13 (2023)

Abstract Background Aging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, but this alone does no

Externí odkaz: https://doaj.org/article/4165b20a8937424aafa2ba2a950a3360

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

Autor: Alina G Mikhailova, Alina A Mikhailova, Kristina Ushakova, Evgeny O Tretiakov, Dmitrii Iliushchenko, Victor Shamansky, Valeria Lobanova, Ivan Kozenkov, Bogdan Efimenko, Andrey A Yurchenko, Elena Kozenkova, Evgeny M Zdobnov, Vsevolod Makeev, Valerian Yurov, Masashi Tanaka, Irina Gostimskaya, Zoe Fleischmann, Sofia Annis, Melissa Franco, Kevin Wasko, Stepan Denisov, Wolfram S Kunz, Dmitry Knorre, Ilya Mazunin, Sergey Nikolaev, Jacques Fellay, Alexandre Reymond, Konstantin Khrapko, Konstantin Gunbin, Konstantin Popadin

Publikováno v: Denisov, S 2022, ' A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand ', Nucleic acids research, vol. 50, pp. 10264–10277 . https://doi.org/10.1093/nar/gkac779

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaf04f68180d9afc181527a26230b3c
https://doi.org/10.1093/nar/gkac779

A>G substitutions on a heavy chain of mitochondrial genome marks an increased level of aerobic metabolism in warm versus cold vertebrates

Autor: Kristina Ushakova, Stepan Denisov, Wolfram S. Kunz, Leonard V. Polishchuk, Konstantin Khrapko, Aleksandr Kuzmin, Dmitry A. Knorre, I. O. Mazunin, Ivan Kozenkov, Alexander Kuptsov, Evgenii O. Tretiakov, Alina G. Mikhailova, Konstantin Popadin, Vsevolod J. Makeev, Viktor A. Shamanskiy, Jacques Fellay, Rita Castilho, Sergey Oreshkov, Dylan Lawless, Alina A. Mihailova, Dmitrii Iliushchenko, V. A. Yurov, Konstantin V. Gunbin, Masashi Tanaka

The variation in the mutational spectrum of the mitochondrial genome (mtDNA) among species is not well understood. Recently, we demonstrated an increase in A>G substitutions on a heavy chain (hereafter AH>GH) of mtDNA in aged mammals, interpreting it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b289e0d13227770f00e24111701861c3
https://doi.org/10.1101/2020.07.25.221184

Risk of mitochondrial deletions is affected by the global secondary structure of the human mitochondrial genome

Autor: Victor Shamanskiy, Alina A. Mikhailova, Kristina Ushakova, Alina G. Mikhailova, Sergei Oreshkov, Dmitry Knorre, Evgenii O. Tretiakov, Natalia Ri, Jonathan B. Overdevest, Samuel W. Lukowski, Irina Gostimskaya, Valerian Yurov, Chia-Wei Liou, Tsu-Kung Lin, Wolfram S. Kunz, Alexandre Reymond, Ilya Mazunin, Georgii A. Bazykin, Konstantin Gunbin, Jacques Fellay, Masashi Tanaka, Konstantin Khrapko, Konstantin Popadin

Aging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Deletions in mitochondrial DNA (mtDNA) are often flanked by direct nucleotide repeats, but this alone doe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b7b41d63cb530114b932e2ac1ae70e6
https://doi.org/10.1101/603282