Synthetic single-framework antibody library integrated with rapid affinity maturation by VL shuffling

Autor: Jukka Hellman, Ari Lehmusvuori, Alex Azhayev, Tuomas Huovinen, T. Savukoski, Timo Lövgren, Eeva-Christine Brockmann, Urpo Lamminmäki, O. Saavalainen, Sultana Akter, Janne Leivo

Publikováno v: Protein engineering, designselection : PEDS. 24(9)

Affinity maturation is often applied to improve the properties of antibodies isolated from universal antibody libraries in vitro. A synthetic human scFv antibody library was constructed in single immunoglobulin framework to enable rapid affinity matu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacce937522408d4ea60c051933ca215
https://pubmed.ncbi.nlm.nih.gov/21680620

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Elevated tumor expression of Astroprincin (FAM171A1) is an independent marker of poor prognosis in colon cancer.

Autor: Kaprio T; Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. tuomas.kaprio@helsinki.fi.; Research Programs Unit, Translational Cancer Medicine, University of Helsinki, Helsinki, Finland. tuomas.kaprio@helsinki.fi., Lindström AM; Department of Pathology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 3 (PB 21), 00014, Helsinki, Finland., Rasila T; Department of Pathology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 3 (PB 21), 00014, Helsinki, Finland., Saavalainen O; Department of Pathology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 3 (PB 21), 00014, Helsinki, Finland., Beilmann-Lehtonen I; Research Programs Unit, Translational Cancer Medicine, University of Helsinki, Helsinki, Finland.; Department of Transplantation and Liver Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Mustonen H; Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Haglund C; Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Translational Cancer Medicine, University of Helsinki, Helsinki, Finland., Andersson LC; Department of Pathology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 3 (PB 21), 00014, Helsinki, Finland.

Publikováno v: BMC gastroenterology [BMC Gastroenterol] 2021 Sep 04; Vol. 21 (1), pp. 341. Date of Electronic Publication: 2021 Sep 04.