Zobrazeno 1 - 9 of 9 pro vyhledávání: '"O. P. Zuiderveld"'
1
Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine
Autor: M. Hoffmann, R. C. Vollinga, Kees Goubitz, Henk Schenk, Wiro M. P. B. Menge, I.J.P. de Esch, R. Leurs, Henk Timmerman, S. Lemstra, U. Appelberg, O. P. Zuiderveld, U. Hacksell
Publikováno v: Journal of Medicinal Chemistry. 42:1115-1122
Various approaches to the synthesis of all four stereoisomers of 2-(1H-imidazol-4-yl)cyclopropylamine (cyclopropylhistamine) are described. The rapid and convenient synthesis and resolution of trans-cyclopropylhistamine is reported. The absolute conf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a80b95a3081cc8ede66354ac64cfbbe
https://doi.org/10.1021/jm9810912
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2
Histamine H1 receptor ligands: part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives
Autor: K, Walczyński, R, Guryn, O P, Zuiderveld, M Q, Zhang, H, Timmerman
Publikováno v: Farmaco (Societa chimica italiana : 1989). 55(9-10)
New 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives were prepared and tested in vitro as H1 receptor antagonists. The compounds with 2-phenylamino substitution with meta-halide substituents at the phen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b83bc061e97383b141264340028c055f
https://pubmed.ncbi.nlm.nih.gov/11152236
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3
Histamine H1 receptor ligands. Part I. Novel thiazol-4-ylethanamine derivatives: synthesis and in vitro pharmacology
Autor: K, Walczyński, H, Timmerman, O P, Zuiderveld, M Q, Zhang, R, Glinka
Publikováno v: Farmaco (Societa chimica italiana : 1989). 54(8)
A series of 2-substituted thiazol-4-ylethanamines have been synthesized and tested for their histaminergic H1-receptor activities. The compounds with 2-phenyl substitution, regardless of the different physicochemical properties of the meta-substituen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55a2f0d1e892170f8fda2f28dd112e6f
https://pubmed.ncbi.nlm.nih.gov/10510850
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4
Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine
Autor: I J, De Esch, R C, Vollinga, K, Goubitz, H, Schenk, U, Appelberg, U, Hacksell, S, Lemstra, O P, Zuiderveld, M, Hoffmann, R, Leurs, W M, Menge, H, Timmerman
Publikováno v: Journal of medicinal chemistry. 42(7)
Various approaches to the synthesis of all four stereoisomers of 2-(1H-imidazol-4-yl)cyclopropylamine (cyclopropylhistamine) are described. The rapid and convenient synthesis and resolution of trans-cyclopropylhistamine is reported. The absolute conf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b3fa4c60649c44db4d787bce2dca640
https://pubmed.ncbi.nlm.nih.gov/10197956
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5
A simple and rapid in vitro test system for the screening of histamine H3 ligands
Autor: R C, Vollinga, O P, Zuiderveld, H, Scheerens, A, Bast, H, Timmerman
Publikováno v: Methods and findings in experimental and clinical pharmacology. 14(10)
A simple and rapid functional test system for the screening of histamine H3 ligands is described. It is based on the inhibitory effect of histamine H3 agonists on electrically-evoked contractile response of isolated guinea pig intestine. Whole jejunu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83a3acc6e6f501849e62342cc30acd62
https://pubmed.ncbi.nlm.nih.gov/1338472
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6
In vitro effect of toluene diisocyanate on beta adrenergic and muscarinic receptor function in lung tissue of the rat
Autor: Aalt Bast, P. J. A. Borm, O. P. Zuiderveld
Publikováno v: Scopus-Elsevier
To investigate the role of pharmacological mechanisms in toluene diisocyanate (TDI) induced occupational asthma, the effects of TDI on rat trachea ring and lung parenchymal strip were studied in vitro. The most prominent effect observed was a stimula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae74e6d0436714c5f9b72cb4d8e346f
https://doi.org/10.1136/oem.46.1.56
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