Zobrazeno 1 - 10
of 28
pro vyhledávání: '"O. O. Ratushna"'
Publikováno v:
The Ukrainian Biochemical Journal, Vol 89, Iss 5, Pp 40-51 (2017)
We have studied the effect of IRE1 signaling enzyme knockdown as well as hypoxia on the expression of genes encoding the important tumor growth related proteins (BRCA1, DEK, BCL2L1, COL6A1, TPD52, HOMER3, and GNPDA1) in U87 glioma cells. It was shown
Externí odkaz:
https://doaj.org/article/9dbe29a7d080434c80511ef8f65a67d7
Autor:
O. V. Halkin, O. O. Riabovol, D. O. Minchenko, A. Y. Kuznetsova, O. O. Ratushna, O. H. Minchenko
Publikováno v:
Biotechnologia Acta, Vol 10, Iss 4, Pp 34-43 (2017)
The aim of this research was to study the effect of glutamine deprivation on the expression of genes encoding for HTRA1/PRSS11, LONP1/PRSS15, and some cathepsins in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1). It
Externí odkaz:
https://doaj.org/article/5d75137d03fd4c3584d2c6d9b8183146
Publikováno v:
The Ukrainian Biochemical Journal, Vol 89, Iss 1, Pp 38-49 (2017)
We have studied the effect of hypoxia on the expression level of mRNA of the basic enzymes of pentose-phosphate cycle (G6PD, TKT, TALDO1, PGLS and RPIA) and glucose-6-phosphate isomerase (GPI) in U87 glioma cells in relation to inhibition of IRE1 (in
Externí odkaz:
https://doaj.org/article/4006cdfdcc244cbc85c50b14427b151c
Autor:
O. H. Minchenko, D. O. Tsymbal, D. O. Minchenko, O. O. Riabovol, O. O. Ratushna, L. L. Karbovskyi
Publikováno v:
The Ukrainian Biochemical Journal, Vol 88, Iss 1, Pp 11-21 (2017)
We have studied the effect of inhibition of IRE1 (inositol requiring enzyme 1), which is a central mediator of endoplasmic reticulum stress and a controller of cell proliferation and tumor growth, on hypoxic regulation of the expression of different
Externí odkaz:
https://doaj.org/article/58663eafb78e4267a48c809d5991aeaf
Autor:
O. H. Minchenko, O.V. Halkin, O. O. Riabovol, D. O. Minchenko, A. Y. Kuznetsova, O. O. Ratushna
Publikováno v:
Biotechnologia Acta, Vol 9, Iss 6, Pp 16-27 (2016)
To study the effect of glucose deprivation on the expression of genes encoding for LONP1/PRSS15 and cathepsins in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1) was the aim of the research. It was shown that glucose
Externí odkaz:
https://doaj.org/article/0924c42fadc6493cabcbbce31930fced
Autor:
O. H. Minchenko, O. O. Riabovol, O. V. Halkin, S. V. Danilovskyi, D. O. Minchenko, O. O. Ratushna
Publikováno v:
Biotechnologia Acta, Vol 9, Iss 5, Pp 7-17 (2016)
We have studied the effect of glucose deprivation on the expression of genes encoding for ubiquitin specific peptidases — USP and autophagy related 7 ATG7 in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1). It was s
Externí odkaz:
https://doaj.org/article/a3ecf959788b49acb1e7090d1ef98b11
Publikováno v:
Biotechnologia Acta, Vol 9, Iss 1, Pp 26-37 (2016)
We have studied the expression of genes encoding proliferation related factors and enzymes such as IL13RA2, KRT18, CD24, ING1, ING2, MYL9, BET1, TRAPPC3, ENDOG, POLG, TSFM, and MTIF2 in U87 glioma cells upon glucose and glutamine deprivation in relat
Externí odkaz:
https://doaj.org/article/a73772a13d0240399b5b222e93230465
Autor:
I. V. Kryvdiuk, D. O. Minchenko, N. A. Hlushchak, O. O. Ratushna, L. L. Karbovskyi, O. H. Minchenko
Publikováno v:
The Ukrainian Biochemical Journal, Vol 87, Iss 6, Pp 36-51 (2015)
Inhibition of IRE1 (inositol requiring enzyme-1), the major signaling pathway of endoplasmic reticulum stress, significantly decreases glioma cell proliferation and tumor growth. We have studied the expression of TNFα-related genes and effect of glu
Externí odkaz:
https://doaj.org/article/0d5c00087c664c90a7337f16233cedc9
Publikováno v:
Біологічні студії, Vol 6, Iss 2, Pp 17-32 (2012)
Accumulating evidence raises the hypothesis that dysregulation of different intrinsic mechanisms which control most metabolic processes are involved in the development of obesity, metabolic syndrome and type 2 diabetes mellitus, the most profound pub
Externí odkaz:
https://doaj.org/article/5dad02b98e5f41aeab48f585e301734f
Autor:
D. O. Minchenko, A. Y. Bobarykina, A. B. Kundieva, N. M. Lypova, I. V. Bozhko, O. O. Ratushna, O. H. Minchenko
Publikováno v:
Біологічні студії, Vol 3, Iss 3, Pp 123-140 (2009)
A bifunctional PFKFB enzyme is a key regulator of glycolysis. Four different genes encode the synthesis of multiple PFKFB isoforms. We analyzed data concerning structural organization of PFKFB genes and alternative splice variants of PFKFB mRNA, as w
Externí odkaz:
https://doaj.org/article/2500192462ac4953808ce71cf7ba30a4