Zobrazeno 1 - 10
of 42
pro vyhledávání: '"O. N. Zhukovskaya"'
Autor:
D. A. Babkov, A. S. Taran, A. A. Shevchenko, L. V. Naumenko, O. N. Zhukovskaya, A. M. Efremov, E. N. Bezsonova, N. A. Lozinskaya, A. A. Spasov
Publikováno v:
Acta Biomedica Scientifica, Vol 9, Iss 1, Pp 116-128 (2024)
Background. Melatonin is an endogenous regulator of intraocular pressure (IOP), but its effectiveness as a drug for glaucoma treatment is limited.The aim of the study. To develop and to validate a virtual screening method to identify bioisosteric ana
Externí odkaz:
https://doaj.org/article/f1d1f8168ad943f3b9de3398ea2a659c
Autor:
A. A. Spasov, O. N. Zhukovskaya, A. I. Rashchenko, A. A. Brigadirova, R. A. Litvinov, N. A. Gurova, A. V. Smirnov, N. G. Pan’shin, H. S.A. Abbas, A. S. Morkovnik
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 10, Iss 6, Pp 549-561 (2023)
Advanced glycation end-products play an important role in the development of diabetic complications, so slowing down of glycated proteins’ cross-links formation have been suggested as a potential therapeutic option for the treatment of vascular dia
Externí odkaz:
https://doaj.org/article/d4d13d12ef394ea1a10e466236f08455
Autor:
E. F. Komarova, A. S. Morkovnik, O. N. Zhukovskaya, E. V. Verenikina, N. A. Shevchenko, D. V. Khodakova, L. Z. Kurbanova, M. V. Mindar, E. V. Zaikina, A. V. Galina
Publikováno v:
Южно-Российский онкологический журнал, Vol 3, Iss 1, Pp 15-21 (2022)
Purpose of the study. Evaluation of the effect of the benzimidazole derivative dihydrobromide‑2-(3,4‑dihydroxyphenyl)- 9‑diethylamino-ethylimidazo-[ 1,2‑a] benzimidazole (RU‑185) on the growth of Lewis lung epidermoid carcinoma and B16-F10
Externí odkaz:
https://doaj.org/article/cf486cc722e24ad581b1eced29035122
Autor:
A. A. Spasov, L. A. Smirnova, O. Yu. Grechko, N. V. Eliseeva, Yu. V. Lifanova, A. I. Rashchenko, O. N. Zhukovskaya, A. S. Morkovnik, V. A. Anisimova
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 9, Iss 2, Pp 149-160 (2021)
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between
Externí odkaz:
https://doaj.org/article/4c0fb6efffa84b93b12c9aa199034531
Autor:
A. A. Spasov, O. N. Zhukovskaya, N. A. Gurova, L. V. Naumenko, N. V. Eliseeva, A. F. Kucheryavenko, V. A. Kosolapov, D. S. Yakovlev, V. Y. Muravyeva, V. A. Babkova, D. A. Babkov, J. V. Lifanova, A. S. Morkovnik
Publikováno v:
Russian Journal of Bioorganic Chemistry. 48:281-291
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::156acb7d34f4b641a7dd7ee9ae58957c
https://doi.org/10.1134/s1068162022020236
https://doi.org/10.1134/s1068162022020236
Autor:
N. D. Bunyatyan, O. N. Zhukovskaya, Lyudmila N. Divaeva, A. V. Morosov, D. O. Mitrakova, M. V. Chernikov, Alexander A. Spasov, I. P. Remezova, Anatolii S. Morkovnik
Publikováno v:
Pharmaceutical Chemistry Journal. 55:544-550
The key synthetic stage (cyclization) of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2-α]benzimidazole dinitrate, which possesses antiulcer activity, was improved by changing the reaction medium and using the imine itself rather than its hydrobromide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62ad8407a11393812456e9c8d67f4b71
https://doi.org/10.1007/s11094-021-02457-2
https://doi.org/10.1007/s11094-021-02457-2
Autor:
Alexander A. Spasov, O. N. Zhukovskaya, O. Yu. Grechko, V. A. Anisimova, Anatolii S. Morkovnik, A. I. Rashchenko, Smirnova La, Natalya V. Eliseeva, Yu. V. Lifanova
Publikováno v:
Farmaciâ i Farmakologiâ (Pâtigorsk), Vol 9, Iss 2, Pp 149-160 (2021)
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78575cc93b37bd61f30abf15b9e86ee1
https://doi.org/10.19163/2307-9266-2021-9-2-149-160
https://doi.org/10.19163/2307-9266-2021-9-2-149-160
Autor:
Alexander A. Spasov, Anatolii S. Morkovnik, V. A. Babkova, R. A. Litvinov, E.V. Sokolova, A. A. Brigadirova, Denis A. Babkov, O. N. Zhukovskaya
Publikováno v:
Russian Chemical Bulletin. 69:774-780
New 2-amino- and 2-hydroxymethylbenzimidazoles were synthesized and used to prepare the previously unknown 1,2,3-tri- and 1,2,3,5-tetrasubstituted benzimidazolium bromides with a biphenyl-containing substituent at the imidazole nitrogen atom. In some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d421698d5acf4bb73ead607a1c2913ea
https://doi.org/10.1007/s11172-020-2832-5
https://doi.org/10.1007/s11172-020-2832-5
Autor:
Ksenia A. Gaidukova, A. F. Kucheryavenko, O. N. Zhukovskaya, Alexander A. Spasov, V. A. Kosolapov
Publikováno v:
Research Results in Pharmacology, Vol 6, Iss 1, Pp 1-9 (2020)
Research Results in Pharmacology 6(1): 1-9
Research Results in Pharmacology 6(1): 1-9
Introduction: Cardiovascular diseases are currently the leading cause of global disability and mortality. According to the centers for disease control and prevention, the average life expectancy of a person would be 10 years longer but for a high pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff15fd55aea0f128bcbcfa074ae1ca3
https://rrpharmacology.pensoft.net/article/50373/download/pdf/
https://rrpharmacology.pensoft.net/article/50373/download/pdf/
Autor:
Alexander A. Spasov, D. V. Mal’tsev, Anatolii S. Morkovnik, O. N. Zhukovskaya, K. T. Sultanova, M. V. Miroshnikov, Maria O. Skripka
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:107-114
This paper presents a study of the anxiolytic activity of compounds that belong to two classes of chemical groups: derivatives of 11H-2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole (BIF) and derivatives of 2-mercaptobenzimidazole (AZH). The stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17c47aa6e10c169fe1ffcabed1c4546c
https://doi.org/10.1134/s1068162020010124
https://doi.org/10.1134/s1068162020010124