Zobrazeno 1 - 10
of 82
pro vyhledávání: '"O. Michael Colvin"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:110-114
The prodrugs cyclophosphamide (CP) and ifosfamide (IF) each metabolize to an active alkylating agent through a cytochrome P450-mediated oxidation at the C-4 position. Competing with this activation pathway are enzymatic oxidations at the exocyclic α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6123767b88270a99d9438e99a74af73e
https://doi.org/10.1002/jlcr.3142
https://doi.org/10.1002/jlcr.3142
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:115-122
A variety of deuterated 3-amino-1-propanols were made by the LiAlD 4 or AlD 3 reduction of nitrile or ester precursors. The labeled aminopropanols and/or deuterated bis(2-chloroethyl)amines were used to synthesize [4,4- 2 H 2 ]-, [6,6- 2 H 2 ]-, [α,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570156c4e3b43b926dd3d79bf6bb32b3
https://doi.org/10.1002/jlcr.1182
https://doi.org/10.1002/jlcr.1182
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:79-84
Reduction of diethyliminodiacetate with [ 3 H]-LiAlH 4 and then reaction with SOCl 2 gave bis(2-chloro-2-[ 3 H] ethyl)amine hydrochloride. This compound, together with [ 33 P]-phosphorus oxychloride, provided for the synthesis of [ 3 H, 33 P]-phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e3a5c245fec4f8af8fdc272218c16b6
https://doi.org/10.1002/jlcr.1157
https://doi.org/10.1002/jlcr.1157
Preclinical Evaluation of Gemcitabine Combination Regimens for Application in Acute Myeloid Leukemia
Publikováno v:
Clinical Cancer Research. 11:4225-4233
The DNA antimetabolite gemcitabine is an anticancer agent with shown preclinical and clinical utility and a low toxicity profile. In this study, we sought to identify and optimize drug partners for binary and tertiary combinations with gemcitabine fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0f82855de6be4e69928e6abc6ab5f2
https://doi.org/10.1158/1078-0432.ccr-04-2106
https://doi.org/10.1158/1078-0432.ccr-04-2106
Autor:
Paul S. Miller, Mateus Webba da Silva, Christopher J. Wilds, Michael P. Gamcsik, Anne M. Noronha, O. Michael Colvin
Publikováno v:
Biochemistry. 43:12549-12554
The solution structure of the undecamer d(CGAAATTTTCG)(2), where T represents a N(3)T-ethyl-N(3)T interstrand cross link, was elucidated using molecular dynamics calculations restrained by NOE and dihedral data obtained from NMR spectroscopy. The eth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa6ab1aee278aed6fd26f0dd6b82720
https://doi.org/10.1021/bi0486435
https://doi.org/10.1021/bi0486435
Autor:
Henry S. Friedman, O. Michael Colvin, Tsung Yen Cheng, Elizabeth G. Grubbs, Zeinab Abdel-Wahab, Bercedis Peterson, Scott K. Pruitt, Omar Abdel-Wahab, Douglas S. Tyler
Publikováno v:
Journal of the American College of Surgeons. 199:419-427
Background Regional perfusion treatments for melanoma, using the alkylating agent melphalan, show variable responses in magnitude and duration. Surprisingly, the potential contribution of alkylating-agent resistance mechanisms to diminish tumor respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::813b2a7443c45a9cccc258721821d91a
https://doi.org/10.1016/j.jamcollsurg.2004.05.271
https://doi.org/10.1016/j.jamcollsurg.2004.05.271
Autor:
Manny D. Bacolod, Stewart P. Johnson, Anthony E. Pegg, M. Eileen Dolan, Robert C. Moschel, Nancy S. Bullock, Qingming Fang, O. Michael Colvin, Paul Modrich, Darell D. Bigner, Henry S. Friedman
Publikováno v:
Molecular Cancer Therapeutics. 3:1127-1135
The chemotherapeutic activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU or carmustine) may be improved by the addition of O6-benzylguanine (O6-BG). The reaction of O6-BG with O6-alkylguanine-DNA alkyltransferase (AGT) prevents the repair of O6-ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1088bc3aecb59aa80cfebac443b9ded5
https://doi.org/10.1158/1535-7163.1127.3.9
https://doi.org/10.1158/1535-7163.1127.3.9
Autor:
Drazen Raucher, Narayanan Balu, Susan M. Ludeman, Matthew R. Dreher, Ashutosh Chilkoti, O. Michael Colvin
Publikováno v:
Journal of Controlled Release. 91:31-43
Thermally responsive elastin-like polypeptides (ELPs) were synthesized by recombinant DNA techniques and conjugated to doxorubicin through an acid-labile hydrazone bond to enable release of the drug in the acidic environment of lysosomes. The thermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8258f46384e87fabb11d989d991d5ca
https://doi.org/10.1016/s0168-3659(03)00216-5
https://doi.org/10.1016/s0168-3659(03)00216-5
Autor:
Paul S. Miller, Mateus Webba da Silva, Anne M. Noronha, David M. Noll, Michael P. Gamcsik, O. Michael Colvin
Publikováno v:
Biochemistry. 41:15181-15188
The solution structure of an interstrand cross-linked self-complementary oligodeoxynucleotide containing directly opposed alkylated N(4)C-ethyl-N(4)C cytosine bases was determined by molecular dynamics calculations guided by NMR-derived restraints. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13277838560836eaa7e19b710da8a463
https://doi.org/10.1021/bi026368l
https://doi.org/10.1021/bi026368l
Autor:
Michael E. Colvin, O. Michael Colvin, S. M. Ludeman, Michael P. Gamcsik, Narayanan Balu, M. Eileen Dolan
Publikováno v:
Chemical Research in Toxicology. 15:380-387
Alkylation of DNA by acrolein and/or chloroacetaldehyde may result in the mutations that lead to the therapy-induced leukemia associated with cyclophosphamide (and ifosfamide) treatment. O(6)-(n-Propanalyl)guanine (O(6)-PAG) and O(6)-(ethanalyl)guani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57dbed5145f4ffb56f881ec07dbfc95
https://doi.org/10.1021/tx0101503
https://doi.org/10.1021/tx0101503