Биоизостерные аналоги коричной кислоты в качестве потенциальных нейропротекторов

Autor: Sergey G. Klochkov, M. Semenova, Yu.R. Aleksandrova, Elena F. Shevtsova, Margarita E. Neganova, V. Semenov, E.A. Lysova, O. M. Redkozubova

Publikováno v: Biomedical Chemistry: Research and Methods; Vol. 1 No. 3 (2018): Special Issue; e00052
Biomedical Chemistry: Research and Methods; Том 1 № 3 (2018): Специальный выпуск; e00052
Biomedical Chemistry: Research and Methods

Compounds that act on mitochondrial functions are considered as promising drugs for the treatment of neurodegenerative diseases and age-related dementias. As a basis for the creation of such potential drugs, bioisosteric cinnamic acid analogs and pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c064b22bccf6e684eb325d2788b879b
http://www.bmc-rm.org/index.php/bmcrm/article/view/52

Targeted Inactivation of the Gene Encoding Gamma-Synuclein Affects Anxiety Levels and Investigative Activity in Mice

Autor: V. S. Kokhan, Tatyana A. Shelkovnikova, Natalia Ninkina, Vladimir L. Buchman, Sergey O. Bachurin, Alexei Bolkunov, Tatyana Strekalova, G. I. Van'kin, O. M. Redkozubova, A. A. Ustiugov

Publikováno v: Neuroscience and Behavioral Physiology. 42:575-581

Gamma (γ) synuclein is a member of the family of synucleins, which are cytoplasmic, predominantly, neuronal, proteins found only in vertebrates. Significant quantities of γ-synuclein are found in the axons and presynaptic terminals of neurons locat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::301c52120eb7dc5cf6e224cbaa85403b
https://doi.org/10.1007/s11055-012-9603-1

The Inhibition of Epileptogenesis During Status Epilepticus by Ginsenosides of Korean Red Ginseng and Ginseng Cell Culture (Dan25)

Autor: S. A. Chepurnov, E V Buzinova, A A Pravdukhina, D A Chepurnova, Jin Kyu Park, U A Pirogov, M Curtis, K.R. Abbasova, N. E. Chepurnova, A A Dubina, L Uva, O M Redkozubova, A A Mirina

Publikováno v: Journal of Ginseng Research. 31:159-174

Pharmacology of Korean Red ginseng gives us unique possibility to develop new class of antiepileptic drugs today and to improve one’s biological activity. The chemical structures of ginsenosides (GS) have some principal differences from well-known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c86758799c9102b3b1c4cb82138dcd16
https://doi.org/10.5142/jgr.2007.31.3.159

N,N'-Substituted Selenoureas as Polyfunctional Antioxidants

Autor: Igor V. Serkov, T. P. Serkova, Elena F. Shevtsova, L. G. Dubova, Alexey N. Proshin, O. M. Redkozubova, Margarita E. Neganova

Publikováno v: Bulletin of experimental biology and medicine. 160(3)

Analysis of antioxidant activity of synthesized selenourea derivatives showed that N,N'-substituted selenoureas inhibited Fe(III)-induced LPO in rat brain homogenate. On the other hand, oxygen- and sulfur-containing analogs exhibited no antioxidant a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cf9e48fbc8dbf151cba70e67a21d44
https://pubmed.ncbi.nlm.nih.gov/26742744

Glutathione‐Sensitive Photosensitizer–Drug Conjugates Target the Mitochondria to Overcome Multi‐Drug Resistance in Cancer.

Autor: Song, Weiguo^1,2 (AUTHOR), Yang, Hekai² (AUTHOR), Wang, Ying² (AUTHOR), Chen, Shuzhen² (AUTHOR), Zhong, Wenda² (AUTHOR) zhongwd@wfmc.edu.cn, Wang, Qian² (AUTHOR), Ding, Wenshuo² (AUTHOR), Xu, Guangzhao^3,4 (AUTHOR), Meng, Chen² (AUTHOR), Liang, Ying⁵ (AUTHOR), Chen, Zhe‐Sheng⁶ (AUTHOR), Cao, Shuhua⁷ (AUTHOR) shuhua@wfu.edu.cn, Wei, Liuya² (AUTHOR) weily@wfmc.edu.cn, Li, Fahui² (AUTHOR) lifh@wfmc.edu.cn

Publikováno v: Advanced Science. 8/14/2024, Vol. 11 Issue 30, p1-15. 15p.