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Autor:
J. M. Brass, H. G. Kulla, Luisa Tonella, M. Fuhrmann, J.-C. Sanchez, B. Lehner, D. Venetz, D. F. Hochstrasser, V. Venetz, A. Tinschert, N. M. Shaw, O. M. Birch
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 22:590-599
The E. coli biotin (bio) operon was modified to improve biotin production by host cells: (a) the divergently transcribed wild-type bio operon was re-organized into one transcriptional unit; (b) the wild-type bio promoter was replaced with a strong ar