Zobrazeno 1 - 10
of 57
pro vyhledávání: '"O. L. Orlova"'
Obtaining a Water-soluble Form of Hydrophobic Indolelocarbazole Derivative Using Solubilizer Complex
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 12, Iss 1, Pp 70-75 (2023)
Introduction. LHS-1269 is an indolocarbazole derivative with high antitumor activity. Due to the hydrophobic properties of the active substance, the use of organic co-solvents – dimethyl sulfoxide (DMSO) and ethanol – is required to obtain an inj
Externí odkaz:
https://doaj.org/article/082255306a0d4d81bb900a9742f76dd3
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 11, Iss 4, Pp 73-78 (2022)
Introduction. N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia synthesized an original derivative of indolocarbazole with the carbohydrate residue xylose, which has a pronounced cytotoxic and anti-angioge
Externí odkaz:
https://doaj.org/article/e6b419d2dd4c442cbca78ecda169e278
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 11, Iss 3, Pp 97-112 (2022)
Introduction. Due to the discovery of antibodies (Ab) targeting molecule with high specificity to the ligand, the "magic bullet" concept has been successfully implemented with various immunoconjugated drugs. Since 1980, Ab conjugates with liposomes,
Externí odkaz:
https://doaj.org/article/b09fffbaf58541528c5816ef912b8f8a
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 11, Iss 1, Pp 82-89 (2022)
Introduction. The Laboratory for the development of dosage forms of the N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russian Federation has developed a composition of an injectable liposomal dosage form base
Externí odkaz:
https://doaj.org/article/1f357dd4999340f4ba807938708a8d35
Autor:
B. Lugen, M. V. Dmitrieva, O. L. Orlova, I. I. Krasnyuk, I. I. Krasnyuk (jr.), D. O. Bokov, O. I. Stepanova, A. V. Belyackaya
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 9, Iss 3, Pp 21-26 (2020)
Introduction. An original N-glycoside derivative of indolocarbazole LHS-1269 with a carbohydrate xylose residue was synthesized at the N.N. Blokhin Russian Cancer Research Center Ministry of Health of Russia. It is characterized by high antitumor act
Externí odkaz:
https://doaj.org/article/45d6ddc44fd9435a9cebe8833ace6d8f
Autor:
T. A. Timofeeva, M. V. Dmitrieva, L. L. Nikolaeva, O. L. Orlova, N. A. Oborotova, A. P. Polozkova, I. I. Krasnyuk
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 8, Iss 2, Pp 66-73 (2019)
Introduction. Liposomal technologies are widely used in medicine and cosmetology as a delivery system for diagnostic and medicinal products and biologically active substances. The undoubted practical importance at the stage of development of a liposo
Externí odkaz:
https://doaj.org/article/6e03f90b753142b6bffe3b032b4ea752
Autor:
I. D. Gulyakin, L. L. Nikolaeva, M. V. Dmitrieva, O. L. Orlova, A. P. Polozkova, N. A. Oborotova, E. V. Ignatieva, N. A. Dmitricheva, I. V. Yartseva, Z. S. Shprakh
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 4, Pp 62-67 (2019)
The work is dedicated to the development of technology for obtaining a freeze-dried dosage form LHS-1208 and the establishment of methods of quality control of the drug. The authors have shown spectrophotometric analysis techniques and flash chromato
Externí odkaz:
https://doaj.org/article/c758b46251224c65b6a7a11af9cbe183
Autor:
I. D. Gulyakin, L. L. Nikolaeva, N. A. Oborotova, M. V. Dmitrieva, A. V. Lantsova, E. V. Sanarova, O. L. Orlova, A. P. Polozkova, H. I. Lavrukhin, N. D. Bunyatyan
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 2, Pp 52-59 (2019)
There are several methods for solving the problem of an adequate dosage form for the hydrophobic and poorly soluble pharmaceutical substances which comprise a structure modification, preparation of solid dispersion systems, a change in pH, the use of
Externí odkaz:
https://doaj.org/article/f62bee0a608c4073866dcc9221c24606
Autor:
O. L. Orlova, L. L. Nikolaeva, L. A. Korol, M. V. Dmitrieva, A. P. Polozkova, A. V. Lantsova, I. D. Gulyakin, N. A. Oborotova
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 6, Iss 5, Pp 440-461 (2018)
Despite the development of biotherapy, chemotherapy remains one of the main methods of treatment of cancer patients. Currently, there are more than 100 anticancer drug substances, however, every year new drugs enter clinical practice and various ther
Externí odkaz:
https://doaj.org/article/d265b4e270f3454ea2dde2130974f77b
Autor:
Ludmila Nikolaeva, Maria Dmitrieva, Elena Ignatyeva, Anna Lantsova, O. L. Orlova, Alexander Kolpaksidi, Ivan I. Krasnyuk
Publikováno v:
International Journal of Applied Pharmaceutics. :232-235
Objective: Development of a technology for the production of a stable injectable dosage form (IDF) of indolocarbazole derivative LHS-1269. Methods: LHS-1269 is an active pharmaceutical ingredient that was synthesized in the N. N. Blokhin National Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a140870676a8613030ed27ab281570ac
https://doi.org/10.22159/ijap.2021v13i6.42685
https://doi.org/10.22159/ijap.2021v13i6.42685