Zobrazeno 1 - 10 of 47 pro vyhledávání: '"O. KOCY"'
1
Addition of Benzylic and Allylic Organozinc and Grignard Reagents to Resin-Bound Imines To Provide α-Branched Secondary Amines Bearing a Wide Variety of Functional Groups. Utility in the Synthesis of β-3 Adrenergic Receptor Agonists
Autor: Zhen-Wei Cai, Philip M. Sher, Ashvinikumar V. Gavai, O. Kocy, and Michael A. Poss, Mark S. Bednarz, William N. Washburn, Gang Wu, Jollie D. Godfrey
Publikováno v: Journal of Combinatorial Chemistry. 7:99-108
Benzylic and allylic organozinc and Grignard reagents have been added to resin-bound imines to provide alpha-branched secondary amines. Many functional groups, including electrophilic groups, were compatible with this methodology. Three modules--a re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826b854036730ee7da0c3d6f13ca040a
https://doi.org/10.1021/cc0498682
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3
A Practical Asymmetric Synthesis of the Antiviral Agent Lobucavir, BMS-180194
Autor: Mueller Richard H, Saleem Ahmad, Truc Chi Vu, O. Kocy, Gregory S. Bisacchi, Thomas P. Kissick, Janak Singh, Toomas Mitt, and Robert Zahler, James E. Heikes, Chris G. Papaioannou, Michael K. Wong, Jollie D. Godfrey
Publikováno v: Organic Process Research & Development. 2:393-399
A practical synthesis of the antiviral agent lobucavir, [1R-(1α,2β,3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one (BMS-180194), is described. The key chiral intermediate, [1S-(1α,2β,3α)]-3-hydroxy-1,2-cyclobutanedimethanol, di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9422289371c492f52c68da1ed5a58c59
https://doi.org/10.1021/op970214+
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4
A new highly enantioselective synthesis of both (R)- and (S)-2-mercaptosuccinic acids
Autor: Joseph E. Sundeen, O. Kocy, Bang-Chi Chen, Mark S. Bednarz
Publikováno v: Tetrahedron: Asymmetry. 9:1641-1644
(R)- and (S)-2-Mercaptosuccinic acids 4 were prepared in five steps in >96% ee and 49–52% overall yield via a new efficient synthesis starting from commercially available L- and D-aspartic acids.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5897edce954d5b216daf34da3edba039
https://doi.org/10.1016/s0957-4166(98)00149-9
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5
BMS-200475, a novel carbocyclic 2′-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
Autor: G. A. Jacobs, S. Innaimo, William A. Slusarchyk, O. Kocy, J.E. Sundeen, Robert Zahler, Alain Martel, M. G. Young, Sam T. Chao, Jean-Paul Daris, Gregory S. Bisacchi, Richard J. Colonno, C. Bachard, Philippe Lapointe, Z. Merchant
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:127-132
BMS-200475, a novel carbocyclic analog of 2′-deoxyguanosine, is a potent inhibitor of hepatitis B virus in vitro (ED50 = 3 nM) with relatively low cytotoxicity (CC50 = 21–120 μM). A practical 10-step asymmetric synthesis was developed affording
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f254f1ed35e99aef5acd2c244ca770e
https://doi.org/10.1016/s0960-894x(96)00594-x
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6
Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists
Autor: Wen-Ching Han, Baerbel R. Brown, Hall Steven E, Harold Goldenberg, Joel C. Barrish, Raj N. Misra, Don N. Harris, Manorama Patel, Philip M. Sher, O. Kocy
Publikováno v: Journal of Medicinal Chemistry. 36:1401-1417
A series of interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles (2) were prepared and evaluated for their thromboxane (TxA2) antagonistic activity in vitro and duration of action in vivo. Examination of the carboxyl side chain indicated that the inter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2eec0b74ad12c61485bbd3c61943f4
https://doi.org/10.1021/jm00062a013
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9
ChemInform Abstract: A New Highly Enantioselective Synthesis of Both (R)- and (S)-2-Mercaptosuccinic Acids
Autor: Bang-Chi Chen, O. Kocy, Mark S. Bednarz, Joseph E. Sundeen
Publikováno v: ChemInform. 29
(R)- and (S)-2-Mercaptosuccinic acids 4 were prepared in five steps in >96% ee and 49–52% overall yield via a new efficient synthesis starting from commercially available L- and D-aspartic acids.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::551dc9acff7e1f6ea3b104e06986bc93
https://doi.org/10.1002/chin.199840064
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