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Akademický článek

Prediction of a positive circumferential resection margin at surgery following neoadjuvant chemotherapy for adenocarcinoma of the oesophagus

Publikováno v: BJS Open, Vol 3, Iss 6, Pp 767-776 (2019)

Background A positive circumferential resection margin (CRM) has been associated with higher rates of locoregional recurrence and worse survival in oesophageal cancer. The aim of this study was to establish if clinicopathological and radiological var

Externí odkaz: https://doaj.org/article/7fbf3f7faa0d4cfa81a84a5495b04c5c

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Akademický článek

Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miRNA-133a expression in diabetic cardiomyopathy

Autor: Boxin Liu, Yan Wei, Jingjing He, Baofeng Feng, Yimeng Chen, Ruiyun Guo, Matthew D. Griffin, Seán O. Hynes, Sanbing Shen, Yan Liu, Huixian Cui, Jun Ma, Timothy O’Brien

Publikováno v: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Background Diabetic cardiomyopathy (DCM) is a serious health-threatening complication of diabetes mellitus characterized by myocardial fibrosis and abnormal cardiac function. Human umbilical cord mesenchymal stromal cells (hUC-MSCs) are a po

Externí odkaz: https://doaj.org/article/64b15c2321bc4d389fa891334d6b314f

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Akademický článek

Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy

Autor: Jingjing He, Boxin Liu, Xiaofeng Du, Yan Wei, Desheng Kong, Baofeng Feng, Ruiyun Guo, Ernest Amponsah Asiamah, Matthew D. Griffin, Sean O. Hynes, Sanbing Shen, Yan Liu, Huixian Cui, Jun Ma, Timothy O’Brien

Publikováno v: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Background and aims Mesenchymal stromal cells (MSCs) a potentially effective disease-modulating therapy for diabetic nephropathy (DN) but their clinical translation has been hampered by incomplete understanding of the optimal timing of admin

Externí odkaz: https://doaj.org/article/5d0a65d625d44f7abac7708253ffd38f

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Akademický článek

Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs

Autor: Tonje S. Steigedal, Jimita Toraskar, Richard P. Redvers, Marit Valla, Synnøve N. Magnussen, Anna M. Bofin, Signe Opdahl, Steinar Lundgren, Bedrich L. Eckhardt, John M. Lamar, Judy Doherty, Richard O. Hynes, Robin L. Anderson, Gunbjørg Svineng

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 4, Pp 387-400 (2018)

Most cancer patients with solid tumors who succumb to their illness die of metastatic disease. While early detection and improved treatment have led to reduced mortality, even for those with metastatic cancer, some patients still respond poorly to tr

Externí odkaz: https://doaj.org/article/2e9bff99dd3c4e2083538751ec1472a9

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Akademický článek

Intravital imaging of metastasis in adult Zebrafish

Autor: David C. Benjamin, Richard O. Hynes

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)

Abstract Background Metastasis is a major clinical problem whose biology is not yet fully understood. This lack of understanding is especially true for the events at the metastatic site, which include arrest, extravasation, and growth into macrometas

Externí odkaz: https://doaj.org/article/dd607a6fbbfa4885ab73dc36ab995df5

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Proteomic profiling of extracellular matrix components from patient metastases identifies consistently elevated proteins for developing nanobodies that target primary tumors and metastases

Autor: Noor Jailkhani, Karl R. Clauser, Howard H. Mak, Steffen Rickelt, Chenxi Tian, Charles A. Whittaker, Kenneth K. Tanabe, Stephen R. Purdy, Steven A. Carr, Richard O. Hynes

Publikováno v: Cancer Research.

Metastases are hard to detect and treat, and they cause most cancer-related deaths. The relative lack of therapies targeting metastases represents a major unmet clinical need. The extracellular matrix (ECM) forms a major component of the tumor microe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a74d7773b7a5e1f2783b0a814c0f6a2
https://doi.org/10.1158/0008-5472.can-22-1532

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