Výsledky vyhledávání - "O. E. Raevskaya"

Quantitative interaction between the structures of organic compounds and their abilities to penetrate the blood-brain barrier

Autor: S. L. Solodova, O. E. Raevskaya, Oleg A. Raevsky, R. Mannhold

Publikováno v: Pharmaceutical Chemistry Journal. 46:133-138

Results of QSAR modeling of the interaction between the structures of organic compounds and their ability to penetrate the blood-brain barrier are presented. Published data for experimental values of logBB for humans (35 compounds) and rats (42 compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2df4ec5a2e9be0de0e693faebbf9412
https://doi.org/10.1007/s11094-012-0748-6

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Acute toxicity evaluation upon intravenous injection into mice: interspecies correlations, lipophilicity parameters, and physicochemical descriptors

Autor: Ya. V. Liplavskii, A.V. Yarkov, Oleg A. Raevsky, O. E. Raevskaya, A. N. Razdol’skii

Publikováno v: Pharmaceutical Chemistry Journal. 46:69-74

Interspecies correlations between the acute intravenous toxicity in mice and toxicities in several species of fish (guppy, fathead minnow, rainbow trout), infusorium Tetrahymena pyriformis, and the freshwater flea Daphnia magna have been studied. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::191b9800100711765682f3b71845aeb7
https://doi.org/10.1007/s11094-012-0736-x

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The computer classification models on the relationship between chemical structures of compounds and drugs with their blood brain barrier penetration ability

Autor: Y. V. Liplavskiy, Oleg A. Raevsky, R. Mannhold, S. L. Solodova, O. E. Raevskaya

Publikováno v: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 6:31-38

Ability of drugs to cross blood-brain barrier (BBB) (BBB+ for BBB-penetrating and BBB- for non-penetrating compounds) is one of the most important properties of chemicals acting on the central nervous system (CNS). This work presents the results of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0f4186ac9b92a80583d7d01f1e24d16
https://doi.org/10.1134/s1990750812010131

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Linear and nonlinear QSAR models of acute intravenous toxicity of organic chemicals for mice

Autor: O. E. Raevskaya, E. A. Liplavskaya, A.V. Yarkov, Oleg A. Raevsky, Andrew Worth

Publikováno v: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 5:213-225

The QSAR analysis of acute intravenous toxicity for mice of 68 monofunctional chemical compounds is presented. These compounds are referred to seven chemical classes: hydrocarbons (6 chemicals), alcohols (13), amides (22), amines (12), ethers (5), ke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6aaf850750b6f29ec19b010b65d1811b
https://doi.org/10.1134/s1990750811030103

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Computer Calculation of Drug Penetration Through the Blood–Brain Barrier

Autor: Sergei V. Trepalin, Oleg A. Raevsky, O. E. Raevskaya, V. Yu. Grigor’ev, A.V. Yarkov, S. L. Solodova

Publikováno v: Pharmaceutical Chemistry Journal. 48:26-28

Alocally written computer program was used to study the structure–activity relationship by analyzing a set of compounds with known blood–brain-barrier penetration values.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bc248d430307920ac75977b7a16729e
https://doi.org/10.1007/s11094-014-1039-1

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QSAR Modeling of Acute Neurotoxicity of Some Organic Solvents with Respect to Rodents

Autor: V. Yu. Grigor’ev, O. E. Raevskaya, Oleg A. Raevsky, A.V. Yarkov

Publikováno v: Biomedical Chemistry: Research and Methods; Vol. 1 No. 3 (2018): Special Issue; e00019
Biomedical Chemistry: Research and Methods; Том 1 № 3 (2018): Специальный выпуск; e00019
Biomedical Chemistry: Research and Methods

Using literature data analysis, the regression models of acute sublethal neurotoxicity of 47 organic solvents with respect to rats and mice have been developed. To construct the models, we used linear regression, random forest and support vector mach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedb92452686e1443b44c681791dd65f
https://doi.org/10.18097/bmcrm00019

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Thermodynamics of organic chemical hydration: QSPR models using physicochemical HYBOT descriptors

Autor: O. E. Raevskaya, R. Mannhold, Y. V. Liplavskiy, Oleg A. Raevsky

Publikováno v: SAR and QSAR in Environmental Research. 20:501-518

Stable and predictive quantitative structure-property relationship (QSPR) models of thermodynamics of chemical hydration (changes in Gibbs energy, DeltaG(air/water), enthalpy, DeltaH(air/water) and entropy DeltaS(air/water)) were obtained on the basi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46ad67e705e065eed4cab3533ac6f66
https://doi.org/10.1080/10629360903278701

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Effect of an activity entailing emotional strain on sensory and secretory processes in the oral cavity

Autor: O. E. Raevskaya, I. Ya. Kon, N. M. Shilina, I. N. Marokko, S. M. Budylina

Publikováno v: Human Physiology. 32:744-747

The changes in taste sensitivity and lipid peroxidation in pooled samples of saliva of students taking examinations were studied. It was found that the changes in the parameters studied were related to the rate of their restoration and depended on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::deb1a7dbd0b14fbee8035c5785fd94ae
https://doi.org/10.1134/s0362119706060211

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