Use of physiologically‐based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity

Autor: Jacqueline G. Gerhart, Fernando O. Carreño, Jennifer L. Ford, Andrea N. Edginton, Eliana M. Perrin, Kevin M. Watt, William J. Muller, Andrew M. Atz, Amira Al‐Uzri, Paula Delmore, Daniel Gonzalez, Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 778-791 (2022)

Abstract Obesity is an increasingly alarming public health threat, with nearly 20% of children classified as obese in the United States today. Children with obesity are commonly prescribed the opioids fentanyl and methadone, and accurate dosing is cr

Externí odkaz: https://doaj.org/article/dd4ab2e51fa44b86a239b72f4ea91718

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Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling

Autor: Daniel Gonzalez, Michael Cohen-Wolkowiez, Karan R. Kumar, Fernando O. Carreño, Andrea N. Edginton, Vincent Harris, Jaydeep Sinha, Christoph P. Hornik, Aruna Rikhi, Eliana M. Perrin, Samit Ganguly, Jacqueline G Gerhart

Publikováno v: Clinical Pharmacokinetics. 61:307-320

While one in five children in the USA are now obese, and more than three-quarters receive at least one drug during childhood, there is limited dosing guidance for this vulnerable patient population. Physiologically based pharmacokinetic modeling can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e2e7ccb3bcc9934e863ff2d0a1a42c
https://doi.org/10.1007/s40262-021-01072-4

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Modified components separation technique: experience treating large, complex ventral hernias at a University Hospital

Autor: José Bueno-Lledo, S Bonafe-Diana, P García Pastor, Fernando Carbonell-Tatay, J Sancho Muriel, Antonio Torregrosa-Gallud, J Iserte-Hernandez, O Carreño-Sáenz

Publikováno v: Hernia : the journal of hernias and abdominal wall surgery
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Background An increasing number of patients have large or complex abdominal wall defects. Component separation technique (CST) is a very effective method for reconstructing complex midline abdominal wall defects in a manner that restores innervated m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616cdfc1044f38607ef4227961415af4
https://doi.org/10.1007/s10029-017-1619-6