Výsledky vyhledávání - "O. C. Leeksma"

Monoclonal antibodies against human platelet glycoprotein IIIa

Autor: A. E. G. Kr. von dem Borne, O. C. Leeksma, Peter M. Lansdorp, P. A. T. Tetteroo

Publikováno v: British Journal of Haematology. 55:509-522

Summary. Two murine monoclonal antibodies specific for human platelets were prepared and characterized by immunofluorescence, immunoprecipitation and by studying their effect on platelet function. Immunoprecipitation with lysates of normal platelets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f9f13cb6151570f81b31cb80b052dc
https://doi.org/10.1111/j.1365-2141.1983.00509.x

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Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase

Autor: O. C. Leeksma, Kensaku Mizuno, Yoshikazu Tsumura, Kazumasa Ohashi, Jiro Toshima

Publikováno v: Biochemical Journal. 387:627-637

TESK1 (testicular protein kinase 1) is a serine/threonine kinase that phosphorylates cofilin and plays a critical role in integrin-mediated actin cytoskeletal reorganization and cell spreading. We previously showed that TESK1 interacts with Sprouty-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71d48577e2869bc8a6328028f250e03
https://doi.org/10.1042/bj20041181

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Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1

Autor: Marcel Spaargaren, Carlie J.M. de Vries, Tanja A. E. van Achterberg, O. C. Leeksma, Clemens Mellink, Hans Pannekoek, Eric Eldering, Yoshikazu Tsumura, Kensaku Mizuno, Wilma G. M. Kroes, Jiro Toshima

Publikováno v: European Journal of Biochemistry. 269:2546-2556

The Drosophila melanogaster protein sprouty is induced upon fibroblast growth factor (FGF)- and epidermal growth factor (EGF)-receptor tyrosine kinase activation and acts as an inhibitor of the ras/MAP kinase pathway downstream of these receptors. By

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e7e324b82667688a183cb28fbfba242
https://doi.org/10.1046/j.1432-1033.2002.02921.x

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Erratum: Germline mutations predisposing to diffuse large B-cell lymphoma

Autor: O C Leeksma, N F de Miranda, H Veelken

Publikováno v: Blood Cancer Journal. 7:e541-e541

Correction to: Blood Cancer Journal (2017) 7, e532; doi:/doifinder/10.1038/bcj.2017.15; published online 17 February 2017 Following the online publication of this article, the author noticed an error in Table 1. Reference 3030 should be 29 as both LI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62e1547b897d5a2780449fcfff8fe44c
https://doi.org/10.1038/bcj.2017.22

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BCR-ABL fusion regions as a source of multiple leukemia-specific CD8+ T-cell epitopes

Autor: Marcel Camps, C. J. M. Melief, Ferry Ossendorp, R. Offringa, O C Leeksma, A. de Ru, Jan W. Drijfhout, Jan H. Kessler, Sandra A. Bres-Vloemans, P.A. van Veelen, Arnout Mulder, I J G Huijbers

Publikováno v: Leukemia. 20(10)

For immunotherapy of residual disease in patients with Philadelphia-positive leukemias, the BCR-ABL fusion regions are attractive disease-specific T-cell targets. We analyzed these regions for the prevalence of cytotoxic T lymphocyte (CTL) epitopes b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bb67c42b58e625a6ebabb2cb0b706c
https://pubmed.ncbi.nlm.nih.gov/16932347

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A BCR-ABL oncoprotein p210b2a2 fusion region sequence is recognized by HLA-DR2a restricted cytotoxic T lymphocytes and presented by HLA-DR matched cells transfected with an Ii(b2a2) construct

Autor: G J, ten Bosch, J H, Kessler, A M, Joosten, A A, Bres-Vloemans, A, Geluk, B C, Godthelp, J, van Bergen, C J, Melief, O C, Leeksma

Publikováno v: Blood. 94(3)

Peptides corresponding to the fusion site in 210 kD BCR-ABL protein b3a2 (p210b3a2) were previously shown to bind to several HLA class I and II alleles. We have found that b3a2 peptide-specific CD4-positive T-helper cells were able to recognize p210b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c91804846b6e9298fc72c73852852c8
https://pubmed.ncbi.nlm.nih.gov/10419896

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BCR-ABL oncoprotein is expressed by platelets from CML patients and associated with a special pattern of CrkL phosphorylation

Autor: G J, ten Bosch, J H, Kessler, J, Blom, A M, Joosten, C, Gambacorti-Passerini, C J, Melief, O C, Leeksma

Publikováno v: British journal of haematology. 103(4)

Constitutive tyrosine phosphorylation of CrkL was recently demonstrated in platelets from chronic myelogenous leukaemia (CML) patients but BCR-ABL tyrosine kinase could not be detected in the platelet lysates. We studied platelets from 14 CML patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d43d9956ecc036038f2b15274b20d4c0
https://pubmed.ncbi.nlm.nih.gov/9886328

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Recognition of BCR-ABL positive leukemic blasts by human CD4+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide

Autor: G J, Bosch, A M, Joosten, J H, Kessler, C J, Melief, O C, Leeksma

Publikováno v: Blood. 88(9)

In chronic myeloid leukemia (CML) the classical 9;22 translocation results in a BCR-ABL fusion gene, which encodes chimeric BCR-ABL fusion 210 kD oncoproteins (p210BCR-ABL). The two main p210BCR-ABL fusion variants in CML, b2a2 and b3a2 are examples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56a93b3aa1fc8adeddb9b273550e8368
https://pubmed.ncbi.nlm.nih.gov/8896419

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