Zobrazeno 1 - 10
of 245
pro vyhledávání: '"O. Buchardt"'
Publikováno v:
Tetrahedron Letters. 36:6941-6944
Novel PNA oligomers containing an N-(aminomethyl) β-alanine backbone (‘retroinverso’ PNA) were prepared via blocksynthesis or via a combination of solution and solid-phase chemistry. The half-life time of the unprotected N terminus is 38 h at pH
Publikováno v:
Tetrahedron Letters. 36:6937-6940
Novel monomeric building blocks 4a and 4b of peptide nucleic acids with an N-(aminomethyl) β-alanine backbone (‘retro-inverso’ PNA) are conveniently synthesized via Hofmann rearrangement. In the major rotamer the side chain carbonyl points towar
Publikováno v:
ChemInform. 25
Publikováno v:
Archives of biochemistry and biophysics. 304(2)
A series of 18 phenacyl bromide and iodoacetamide analogues have been synthesized and used to alkylate Met-398 situated in the S'1 binding site of carboxypeptidase Y. The course of the reactions was monitored by measurements of the peptidase and este
Publikováno v:
Anti-cancer drug design. 8(1)
The binding of peptide nucleic acids (PNAs) T10-LysNH2, T5CT4-LysNH2 and T2CT2CT4-LysNH2 to double-stranded DNA targets A10, A5GA4 and A2GA2GA4 was studied by nuclease S1 probing. It is found that the PNAs bind preferentially to their complementary t
Publikováno v:
Peptide research. 5(6)
The C-terminal amidation of calcitonin represents an important technological problem. A method using a serine carboxypeptidase-catalyzed transpeptidation reaction in combination with photochemical cleavage to give the warranted peptide amide is descr
Autor:
Ulla Christensen, Erik Tüchsen, Bjørn Andersen, Gustav Schroll, O. Dahl, O. Buchardt, G. Schroll
Publikováno v:
Acta Chemica Scandinavica. :81-87
Publikováno v:
Tetrahedron. 37:789-793
Irradiation of pyridine N-oxide (1) in the presence of secondary amines in aqueous solution produces mixtures of isiomeric 2Z, 4E and N,N-disubstituted all-E 5 amino-2,4-pentadienenitriles (3 and 4) in fair yields and with an ease to render the react
Publikováno v:
Acta Chemica Scandinavica. :171-176
The crystal structure of D,L-(2-hydroxyphenyl)-alanine has been determined by X-ray methods using 1971 observed reflections. The crystals are monoclinic, space group P2-1, with four molecules in the unit cell of dimensions a=6.32-5 A; b=26.48-9 A; c=
Publikováno v:
Acta Chemica Scandinavica. :45-50