Zobrazeno 1 - 10
of 63
pro vyhledávání: '"O. Berk Usta"'
Autor:
Ziya Isiksacan, Nishaka William, Rahime Senturk, Luke Boudreau, Celine Wooning, Emily Castellanos, Salih Isiksacan, Martin L. Yarmush, Jason P. Acker, O. Berk Usta
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Red blood cell (RBC) transfusions facilitate many life-saving acute and chronic interventions. Transfusions are enabled through the gold-standard hypothermic storage of RBCs. Today, the demand for RBC units is unfulfilled, partially due to t
Externí odkaz:
https://doaj.org/article/be755210cf55478ca1f637dfa842c2ea
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Supercooled preservation (SCP) is a technology that involves cooling a substance below its freezing point without initiating ice crystal formation. It is a promising alternative to prolong the preservation time of cells, tissues, engineered tissue pr
Externí odkaz:
https://doaj.org/article/e344a2b713ed478eab6b10a1b1a2299e
Autor:
A. Aslihan Gokaltun, Letao Fan, Luca Mazzaferro, Delaney Byrne, Martin L. Yarmush, Tianhong Dai, Ayse Asatekin, O. Berk Usta
Publikováno v:
Bioactive Materials, Vol 25, Iss , Pp 415-429 (2023)
Despite decades of efforts, state-of-the-art synthetic burn dressings to treat partial-thickness burns are still far from ideal. Current dressings adhere to the wound and necessitate debridement. This work describes the first “supramolecular hybrid
Externí odkaz:
https://doaj.org/article/a35a2967a1464c16ba1ea17553284c02
Autor:
Letao Fan, Aslihan Gokaltun, Sarah Maggipinto, Yoshinori Kitagawa, Jeevendra Martyn, Heidi Yeh, Basak E. Uygun, Martin L. Yarmush, O. Berk Usta
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 2, Pp 243-261 (2023)
Background & Aims: Alterations in mitochondrial morphology and function and increased oxidative stresses in hepatocytes are well established in nonalcoholic fatty liver disease (NAFLD). Patients can undergo lifestyle changes, especially in earlier NA
Externí odkaz:
https://doaj.org/article/eb0b08a16174407d815dc363b82b8e1b
Autor:
Nishaka William, Ziya Isiksacan, Olga Mykhailova, Carly Olafson, Martin L. Yarmush, O. Berk Usta, Jason P. Acker
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: Adenosine triphosphate (ATP) levels guide many aspects of the red blood cell (RBC) hypothermic storage lesions. As a result, efforts to improve the quality of hypothermic-stored red cell concentrates (RCCs) have largely centered around de
Externí odkaz:
https://doaj.org/article/4519cfa76d9e4d64ba0519eac92f672b
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Aggregation of human red blood cells (RBC) is central to various pathological conditions from bacterial infections to cancer. When left at low shear conditions or at hemostasis, RBCs form aggregates, which resemble stacks of coins, known as
Externí odkaz:
https://doaj.org/article/abe7eee3f2a44f6d91232c9b0145a4cd
Autor:
Camilo Rey-Bedon, Peony Banik, Aslihan Gokaltun, O. Hofheinz, Martin.L. Yarmush, M. Korkut Uygun, O. Berk Usta
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112377- (2022)
Drug-drug-interactions (DDIs) occur when a drug alters the metabolic rate, efficacy, and toxicity of concurrently used drugs. While almost 1 in 4 adults now use at least 3 concurrent prescription drugs in the United States, the Non-alcoholic fatty li
Externí odkaz:
https://doaj.org/article/542dafa1c9b84743b7c95ba44c8e52df
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Supercooled water is susceptible to spontaneous freezing, and preventing this process is a challenge. Here, the authors use surface sealing with immiscible liquids to eliminate primary ice nucleation at the water/air interface, enabling deep supercoo
Externí odkaz:
https://doaj.org/article/1795edf96b9b4b04a506a1de7df517ee
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 48:102651
Publikováno v:
Biotechnol Bioeng
Oxygen is vital to the function of all tissues including the liver and lack of oxygen, i.e. hypoxia, can result in both acute and chronic injuries to the liver in vivo and ex vivo. Furthermore, a permanent oxygen gradient is naturally present along t