Zobrazeno 1 - 10
of 21
pro vyhledávání: '"O. B. Ryabova"'
Publikováno v:
Pharmaceutical Chemistry Journal. 53:781-785
Efficacious antiviral analogs of viral nucleoside DNA-polymerase inhibitors are used to treat infections caused by herpes simplex virus (HSV) although their widespread use in clinical practice has caused drug-resistant HSV strains to develop. The dru
Autor:
Vincent Desfontaine, Laurent A. Decosterd, Vadim Makarov, Anthony Vocat, O. B. Ryabova, Jeff Pitteloud, Stewart T. Cole, Anton Ivanyuk, Sylvie Guinchard, Sandra Cruchon, Dany Spaggiari, Thierry Buclin, Emilyne Blattes, Lorenzo Ciullini, Carine Bardinet
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217139 (2019)
PLoS ONE
PloS one, vol. 14, no. 5, pp. e0217139
PLoS ONE
PloS one, vol. 14, no. 5, pp. e0217139
The emergence of Mycobacterium tuberculosis strains resistant to current first-line antibiotic regimens constitutes a major global health threat. New treatments against multidrug-resistant tuberculosis (MDR-TB) are thus eagerly needed in particular i
Autor:
Boris Nikonenko, Anthony Vocat, O. B. Ryabova, Stewart T. Cole, Vadim Makarov, Elena G. Salina
Publikováno v:
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 23(11)
Tuberculosis (TB) treatment is confounded by the range of metabolic states displayed by Mycobacterium tuberculosis, by the long duration required and by the increasing prevalence of drug-resistant strains. Latent TB infection is especially difficult
Autor:
Thierry Buclin, Ruben C. Hartkoorn, Florence Pojer, Vadim Makarov, Astrid M. van der Sar, Laurent A. Decosterd, Anthony Vocat, Ming Zhang, O. B. Ryabova, Stewart T. Cole, Paul J. Dyson, Koen Andries, Benoit Lechartier, João Neres, Wilbert Bitter, Susanne A. Raadsen, Nicolas Widmer
Publikováno v:
Embo Molecular Medicine, vol. 6, no. 3, pp. 372-383
EMBO Molecular Medicine, Vol 6, Iss 3, Pp 372-383 (2014)
EMBO Molecular Medicine
Makarov, V, Lechartier, B, Zhang, M, Neres, J, van der Sar, A M, Raadsen, S A, Hartkoorn, R C, Ryabova, O B, Vocat, A, Decosterd, L A, Widmer, N, Buclin, T, Bitter, W, Andries, K, Pojer, F, Dyson, P J & Cole, S T 2014, ' Towards a new combination therapy for tuberculosis with next generation benzothiazinones ', Embo Molecular Medicine, vol. 6, no. 3, pp. 372-383 . https://doi.org/10.1002/emmm.201303575
Embo Molecular Medicine, 6(3), 372-383. Wiley-Blackwell
EMBO Molecular Medicine; Vol 6
EMBO Molecular Medicine, Vol 6, Iss 3, Pp 372-383 (2014)
EMBO Molecular Medicine
Makarov, V, Lechartier, B, Zhang, M, Neres, J, van der Sar, A M, Raadsen, S A, Hartkoorn, R C, Ryabova, O B, Vocat, A, Decosterd, L A, Widmer, N, Buclin, T, Bitter, W, Andries, K, Pojer, F, Dyson, P J & Cole, S T 2014, ' Towards a new combination therapy for tuberculosis with next generation benzothiazinones ', Embo Molecular Medicine, vol. 6, no. 3, pp. 372-383 . https://doi.org/10.1002/emmm.201303575
Embo Molecular Medicine, 6(3), 372-383. Wiley-Blackwell
EMBO Molecular Medicine; Vol 6
The benzothiazinone lead compound, BTZ043, kills Mycobacterium tuberculosis by inhibiting the essential flavo-enzyme DprE1, decaprenylphosphoryl-beta-D-ribose 2-epimerase. Here, we synthesized a new series of piperazine-containing benzothiazinones (P
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:55-60
From in vivo observations, a majority of M. tuberculosis cells in latently infected individuals are in a dormant and probably nonculturable state, display little metabolic activity, and are phenotypically resistant to antibiotics. Despite many attemp
Autor:
Paolo Iadarola, Edda De Rossi, Renato Fani, Vadim Makarov, O. B. Ryabova, Giovanna Riccardi, Viola Camilla Scoffone, Marco Fumagalli, Marco Fondi, Silvia Buroni
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 6 (2015)
Frontiers in Microbiology, Vol 6 (2015)
Burkholderia cenocepacia is a major concern for people suffering from cystic fibrosis as it contributes to serious respiratory tract infections. The lack of drugs effective against this opportunistic pathogen, along with the high level of resistance
Autor:
V. G. Granik, L. M. Alekseeva, N. B. Grigor'ev, O. B. Ryabova, E. Yu. Khmel'nitskaya, Vadim Makarov
Publikováno v:
Russian Chemical Bulletin. 54:2873-2879
On heating at pH 6.86, 4-(N,N-dialkylthiocarbamoylthio)-5-nitropyrimidines are transformed into dithiolopyrimidines, which are either oxidized to bis(4-dialkylthiocarbamoylpyrimidin-5-yl) disulfides or converted into 4,6-diamino-5-nitropyrimidine der
Autor:
Vadim Makarov, Vladimir V. Chernyshev, Alexander S. Shashkov, L. M. Alekseeva, V. G. Granik, O. B. Ryabova
Publikováno v:
Russian Chemical Bulletin. 54:1907-1914
ortho-Chloroaryl(hetaryl)carboxamides containing one or two nitro groups at positions 3 and/or 5 of the ring undergo condensation accompanied by the pyrimidine ring closure on refluxing in an excess of sodium methoxide to form bicyclic products, viz.
Publikováno v:
Chemistry of Heterocyclic Compounds. 39:238-243
The reaction of 3,5-di-(N,N-dimethylaminomethylene)amino-4-methoxycarbonylpyrazole and 3,5-di-(N,N-dimethylaminomethylene)amino-4-cyanopyrazole with different amines occurs with formation of pyrazolo[3,4-d]pyrimidines. In some reactions, an excess of
Publikováno v:
Chemistry of Heterocyclic Compounds. 38:947-953
The interaction of 3,5-bis(N,N-dimethylaminomethylene)amino-1-methyl-4-nitropyrazole with amines proceeds regioselectively with the formation of 3-amino-5-(N,N-dimethylaminomethylene)amino-1-methyl-4-nitropyrazole. Amines are converted in this way in