Výsledky vyhledávání - "O. A. Salaznikova"

Uracil Hydroxybenzamides as Potential Antidiabetic Prodrugs

Autor: Alexander A. Spasov, A. F. Kucheryavenko, A. I. Rashchenko, A. K. Brel, S. S. Popov, O. A. Salaznikova, R. A. Litvinov, S. V. Lisina

Publikováno v: Pharmaceutical Chemistry Journal. 53:511-515

A series of N1, N3-bis-hydroxybenzoyl, -acetoxybenzoyl, and -methoxybenzoyl uracil derivatives were synthesized. All compounds were screened for the ability to rupture protein cross links and antiglycating, chelating, and antiaggregant properties, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::931051ec8c0db67ba6aa655f0fb58e9d
https://doi.org/10.1007/s11094-019-02029-5

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Evaluation of N-Hydroxy-, N-Metoxy-, and N-Acetoxybenzoyl-Substituted Derivatives of Thymine and Uracil as New Substances for Prevention and Treatment of Long-Term Complications of Diabetes Mellitus

Autor: A. V. Ivanov, A. F. Kucheryavenko, V. V. Batrakov, O. A. Salaznikova, D. D. Shamshina, R. A. Litvinov, S. V. Lisina, A. I. Rashchenko, A. K. Brel, Yu. N. Budaeva, Alexander A. Spasov

Publikováno v: Russian Journal of Bioorganic Chemistry. 44:769-777

New uracil and thymine derivatives, N1-,N3- and N1,N3-(RO-benzoyl)-(1H,3H)-pyrimidine- 2,4-diones, were synthesized (RO- is hydroxy, acetoxy- or methoxy-group). The compounds were studied in a complex of in vitro tests for the ability to inhibit the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d7ac8048cfb33b48259a30ae0c81620
https://doi.org/10.1134/s1068162019010163

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Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2-A]Benzimidazoles

Autor: Alexander A. Spasov, V. A. Kuznetsova, Denis A. Babkov, Natalya V. Eliseeva, K. A. Gaidukova, O. N. Zhukovskaya, Tat’yana A. Kuz’menko, A. I. Rashchenko, Anatolii S. Morkovnik, O. Yu. Grechko, A. F. Kucheryavenko, O. A. Salaznikova, V. A. Anisimova

Publikováno v: Pharmaceutical Chemistry Journal. 52:385-391

A series of 2-(4-trifluoromethylphenyl)- and 2-trifluoromethyl-9-dialkylaminoalkylimidazo[1,2-a]benzimidazoles were synthesized for the first time by reacting 2-amino-1-dialkylaminoalkylbenzimidazoles and 2-bromo-1-[(4-trifluoromethyl)phenyl]ethanone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51d3506be801f82a50131f2b7beb3341
https://doi.org/10.1007/s11094-018-1826-1

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The Search for Pharmacologically Active Compounds Among the 2-Dialkylaminobenzimidazoles

Autor: N. A. Gurova, E. V. Reznikov, Alexander A. Spasov, D. S. Yakovlev, O. N. Zhukovskaya, Ya. V. Morkovina, O. A. Salaznikova, D. V. Mal’tsev, A. A. Brigadirova, A. F. Kucheryavenko, V. A. Anisimova, V. A. Kuznetsova, V. V. Gurova, O. A. Solov’eva

Publikováno v: Pharmaceutical Chemistry Journal. 51:182-186

Heating of substituted benzimidazole-2-sulfonic acids in the presence of excess quantities of secondary amines was used to synthesize dialkylaminobenzimidazoles. Experimental studies of potential antiarrhythmic, antiaggregation, hemorheological, AT1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e833820550552b8faa61346222fd6bd
https://doi.org/10.1007/s11094-017-1578-3

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Synthesis and pharmacological activity of amides of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyln-acetic acids

Autor: K. V. Lenskaya, O. A. Salaznikova, Alexander A. Spasov, T. M. Mitina, N. A. Gurova, D. S. Yakovlev, N. A. Kolobrodova, O. Yu. Grechko, V. A. Kosolapov, V. A. Kuznetsova, E. V. Tibir’kova, D. V. Mal’tsev, I. E. Tolpygin, V. A. Anisimova

Publikováno v: Pharmaceutical Chemistry Journal. 46:647-652

A series of amides of 2,3-dihydroimidazo- and 2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazolyl-N-acetic acids were synthesized. Their pharmacological activity was studied. It was established that the synthesized substances possessed antiaggregant pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9ab5003de21e15cc0328f0e9436dacc
https://doi.org/10.1007/s11094-013-0862-0

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Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles

Autor: T. M. Mitina, Alexander A. Spasov, I. E. Tolpygin, K. V. Lenskaya, N. A. Kolobrodova, D. S. Yakovlev, V. A. Kosolapov, M. P. Voronkova, L. V. Naumenko, O. A. Salaznikova, L. V. El’tsova, V. A. Anisimova, N. A. Gurova

Publikováno v: Pharmaceutical Chemistry Journal. 46:325-330

The synthesis of 10-chloroethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazole was described. The nucleophilic substitution of the chlorine atom by various amines was studied. As a result, 10-alkylaminoethyl-substituted derivatives of this tricycle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a01521cacc002c1206f535986728d8b
https://doi.org/10.1007/s11094-012-0791-3

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Synthesis and pharmacological activity of 9-R-2-halogenophenylimidazo[1,2-a]benzimidazoles

Autor: Alexander A. Spasov, I. I. Goryagin, N. V. Kirillova, O. Yu. Grechko, V. A. Kosolapov, Vladimir I. Minkin, I. E. Tolpygin, L. V. Naumenko, O. A. Salaznikova, D. S. Yakovlev, E. V. Tibir’kova, M. V. Chernikov, A. Yu. Stukovina, N. A. Gurova, V. A. Anisimova

Publikováno v: Pharmaceutical Chemistry Journal. 44:345-351

Taking into account the structure—activity relationship established previously for imidazobenzimidazole derivatives with high hemorheological activity, several new 9-R-2-halogenophenyl-substituted imidazo[1,2-a]benzimidazoles with C2 fluoro-, chlor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb1c10c1563d285c9608d6b51e57ff14
https://doi.org/10.1007/s11094-010-0465-y

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Synthesis and pharmacological activity of 1-dialkyl(alkyl)aminoethyl-2,3-dihydroimidazo[1,2-a]benzimidazoles

Autor: O. A. Salaznikova, D. S. Yakovlev, N. A. Gurova, V. A. Anisimova, L. V. El’tsova, Alexander A. Spasov, L. V. Naumenko, I. I. Goryagin, M. V. Chernikov, N. A. Kolobrodova, V. A. Kosolapov, I. E. Tolpygin

Publikováno v: Pharmaceutical Chemistry Journal. 44:241-244

In continuation of the investigation of 1-dialkylaminoethyl-2,3-dihydroimidazo[1,2-a]benzimidazoles demonstrating serotoninergic activity, several new substances of this class with 4-substituted piperazines and piperidines as amine moieties were synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe27498cfa2c6a59dbcb9943ff117c3a
https://doi.org/10.1007/s11094-010-0439-0

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[Effect of hypoglycemic drugs on hemostasis]

Autor: A A, Spasov, A F, Kucheriavenko, O A, Salaznikova

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 73(8)

The effects of hypoglycemic drugs (gliclazide, glibenclamide) and new sugar-lowering drug diabenol on the coagulation chain of hemostasis and fibrinolytic system of blood have been studied in intact rats and in rats with experimental diabetes mellitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5495efffc78102b7613ffa1b533373f1
https://pubmed.ncbi.nlm.nih.gov/20919554

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[Effect of hypoglycemic drugs on hemorheological parameters]

Autor: A A, Spasov, A F, Kucheriavenko, O A, Salaznikova

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 72(5)

The hemorheological activity of a series of hypoglycemic drugs and the new antidiabetic agent RU-254 (9-diethylaminoethyl-2,3-dihydroimidazo[1, 2-a]benzimidazole dihydrochloride) was studied by comparative tests on rats with model diabetes. All the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::885278e193ca2b7ecf845afed98090f0
https://pubmed.ncbi.nlm.nih.gov/19928573

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