Výsledky vyhledávání - "O. A. Goroshko"

Akademický článek

Analysis of Pharmacokinetic Parameters of Acetylsalicylic Acid for Prediction of Potential Nephrotoxic Effects

Autor: L. M. Krasnykh, O. A. Goroshko, G. F. Vasilenko, G. I. Gorodetskaya, V. V. Smirnov, T. A. Rodina

Publikováno v: Безопасность и риск фармакотерапии, Vol 9, Iss 4, Pp 209-215 (2021)

Nonsteroidal anti-inflammatory drugs, including acetylsalicylic acid, can have a dose-dependent nephrotoxic effect. The study of the pharmacokinetics of acetylsalicylic acid products will contribute to timely detection and correction of side effects

Externí odkaz: https://doaj.org/article/04ff71dfc9f64d4881746f18b981fe20

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Akademický článek

The Mechanism of Action of Follistatin-like Protein-1 (FSTL-1)

Autor: V. G. Kukes, Yu. V. Olefir, B. K. Romanov, A. B. Prokofiev, E. V. Parfenova, M. A. Boldyreva, O. A. Goroshko, O. K. Parfenova, A. A. Gazdanova, E. Yu. Demchenkova

Publikováno v: Регуляторные исследования и экспертиза лекарственных средств, Vol 9, Iss 4, Pp 256-260 (2019)

The paper provides current data on some proteins of the TGF- p family which are potentially capable of exerting a protective effect in diseases of the heart, lungs, placenta, gonads, and pancreas. The study investigated the anti-inflammatory properti

Externí odkaz: https://doaj.org/article/84309a48baff446b9dc2acc66bfa1831

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Akademický článek

Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress

Autor: O. A. Goroshko, L. M. Krasnykh, V. G. Kukes, V. I. Zozina

Publikováno v: Регуляторные исследования и экспертиза лекарственных средств, Vol 9, Iss 3, Pp 146-152 (2019)

The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants. Changes in electron redox pathways cause uncontrolled re

Externí odkaz: https://doaj.org/article/f89fa6c155174aeaa7b594cfb3428247

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Akademický článek

THE IMPACT OF CARDIOVASCULAR AND BRONCHOPULMONARY DISEASES ON COENZYME Q10 PLASMA CONCENTRATION

Autor: V. I. Zozina, E. S. Melnikov, L. M. Krasnykh, O. A. Goroshko, V. G. Kukes

Publikováno v: Сеченовский вестник, Vol 10, Iss 1, Pp 16-21 (2019)

Introduction. Coenzyme Q10 plays an important role in the human body. Its main function is not only the transfer of electrons in the mitochondrial respiratory chain for the ATP synthesis, but it is also one of the most powerful antioxidants in the bo

Externí odkaz: https://doaj.org/article/eb37b875b5954c5bb24f293486fa98e1

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Akademický článek

THE MODERN METHODS OF ANALYSIS OF OXIDIZED AND REDUCED FORMS OF COENZYME Q₁₀ IN BIOMATERIAL (REVIEW)

Autor: V. I. Zozina, O. A. Goroshko, L. M. Krasnykh, V. G. Kukes

Publikováno v: Разработка и регистрация лекарственных средств, Vol 0, Iss 1, Pp 84-88 (2019)

In the human body, coenzyme Q10 is in the oxidized and reduced forms and can be found in every organ. The review describes modern HPLC methods of coenzyme Q10 analysis using electrochemical, spectrophotometric and mass spectrometric detectors. In the

Externí odkaz: https://doaj.org/article/aabeadcb51b545108fd0e91deb3e7c98

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Akademický článek

Differences in the pharmacokinetics of ibuprofen in monoand multi-component drugs

Autor: L. M. Krasnykh, V. V. Smirnov, G. F. Vasilenko, O. A. Goroshko, E. A. Egorenkov, V. I. Zozina

Publikováno v: Регуляторные исследования и экспертиза лекарственных средств, Vol 7, Iss 2, Pp 117-121 (2018)

The article reports the results of the study which investigated the pharmacokinetics of mono- and multi-component ibuprofen-containing drugs following single oral administration to healthy volunteers. Plasma concentration of ibuprofen was determined

Externí odkaz: https://doaj.org/article/f680a1527d9740ec875f7eb18c42a6f0

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