Výsledky vyhledávání - "O. A. Bizzozero"

Nitric oxide reduces the palmitoylation of rat myelin proteolipid protein by an indirect mechanism

Autor: O A, Bizzozero, H, Bixler, J, Parkhani, A, Pastuszyn

Publikováno v: Neurochemical research. 26(10)

Brain slices from 20-day-old rats were incubated with [3H]palmitate for 2 hours in the absence or presence of the NO-donors S-nitroso-N-acetyl-penicillamine (SNAP), ethyl-2-[hydroxyimino]-5-nitro-3-hexeneamide (NOR-3), 4-phenyl-3-furoxan carbonitrile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d5d0be24d12db879511b51dc4278519
https://pubmed.ncbi.nlm.nih.gov/11700955

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Chemical deacylation reduces the adhesive properties of proteolipid protein and leads to decompaction of the myelin sheath

Autor: O A, Bizzozero, H A, Bixler, J D, Davis, A, Espinosa, A M, Messier

Publikováno v: Journal of neurochemistry. 76(4)

Myelin proteolipid protein (PLP) contains thioester-bound, long-chain fatty acids which are known to influence the structure of the molecule. To gain further insights into the role of this post-translational modification, we studied the effect that c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4661420762bae7397077f9cd542eac5
https://pubmed.ncbi.nlm.nih.gov/11181833

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Conserved fatty acid composition of proteolipid protein during brain development and in myelin subfractions

Autor: A M, Messier, O A, Bizzozero

Publikováno v: Neurochemical research. 25(4)

Myelin proteolipid protein (PLP) is modified after translation by the attachment of long-chain fatty acids to several cysteine residues. In this study, the amount and pattern of fatty acids covalently bound to rat PLP were determined during brain dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39dd04abaa41dde59416391edbd1df57
https://pubmed.ncbi.nlm.nih.gov/10823577

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Fatty acid composition of myelin proteolipid protein during vertebrate evolution

Autor: O A, Bizzozero, M B, Lees

Publikováno v: Neurochemical research. 24(2)

The hydrophobic myelin proteolipid protein (PLP) contains covalently bound long-chain fatty acids which are attached to intracellular cysteine residues via thioester linkages. To gain insight into the role of acylation in the structure and function o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5bac90c5cec2aabb06e0e744b4861463
https://pubmed.ncbi.nlm.nih.gov/9972874

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Palmitoylation of myelin P0 protein is independent of its synthesis and parallels that of phospholipids

Autor: R F, Melendez, O A, Bizzozero

Publikováno v: Journal of the peripheral nervous system : JPNS. 1(1)

To determine whether the acyl chains modifying P0, the major protein of PNS myelin, turn over independently of the protein backbone, sciatic nerve slices from 10 to 65 day-old rats were incubated with a mixture of [3H]palmitic acid and [14C]amino aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b76c8fec2288e7de5bea00512ee70b97
https://pubmed.ncbi.nlm.nih.gov/10970118

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Chemical analysis of acylation sites and species

Autor: O A, Bizzozero

Publikováno v: Methods in enzymology. 250

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ddf3a4cac912e81a21532cee52a49a9
https://pubmed.ncbi.nlm.nih.gov/7651165

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Characterization of proteolipid protein fatty acylesterase from rat brain myelin

Autor: O A, Bizzozero, J, Leyba, D J, Nuñez

Publikováno v: The Journal of biological chemistry. 267(11)

A protein fatty acylesterase activity that catalyzes the removal of fatty acid from exogenous proteolipid protein (PLP) has been demonstrated in isolated rat brain myelin. Optimum enzyme activity for the deacylation of PLP was obtained in 0.5% Triton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad4b1e3e960bfc519398b5cfa9811b97
https://pubmed.ncbi.nlm.nih.gov/1560018

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Rapid metabolism of fatty acids covalently bound to myelin proteolipid protein

Autor: O A, Bizzozero, L K, Good

Publikováno v: The Journal of biological chemistry. 266(26)

Proteolipid protein (PLP), the major protein of central nervous system myelin, contains approximately 2 mol of covalently bound fatty acids. In this study, the in vivo turnover rate of the acyl chains bound to PLP was determined in 40-day-old rats af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7033007afd03ac4b74805429982d0821
https://pubmed.ncbi.nlm.nih.gov/1894605

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