Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

Autor: François-Xavier Cantrelle, Anne Loyens, Xavier Trivelli, Oliver Reimann, Clément Despres, Neha S. Gandhi, Christian P. R. Hackenberger, Isabelle Landrieu, Caroline Smet-Nocca

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

Phosphorylation of the neuronal microtubule-associated Tau protein plays a critical role in the aggregation process leading to the formation of insoluble intraneuronal fibrils within Alzheimer’s disease (AD) brains. In recent years, other posttrans

Externí odkaz: https://doaj.org/article/8d012c8e67d54abab12653fa56319bc6

Variation of ewe olfactory secretome during a ram effect

Autor: Cann, Paul, Le Danvic, Chrystelle, Porte, Chantal, Chesneau, Didier, Keller, Matthieu, Nagnan-Le Meillour, Patricia

Publikováno v: Frontiers in Veterinary Science
Frontiers in Veterinary Science, 2023, 9, pp.1033412. ⟨10.3389/fvets.2022.1033412⟩

IntroductionUnder temperate latitudes, reproduction in Ovis aries displays a marked seasonality, governed by the photoperiod. In natural conditions, the transition between sexual rest and sexual activity in both sexes is induced by the decrease of da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0189865e5cfee9e4b1ebca52dbd8cd94
https://hal.inrae.fr/hal-04082682/document

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Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies

Autor: Galina Limorenko, Hilal A. Lashuel

Publikováno v: Chemical Society reviews. 51(2)

Converging evidence continues to point towards Tau aggregation and pathology formation as central events in the pathogenesis of Alzheimer's disease and other Tauopathies. Despite significant advances in understanding the morphological and structural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee59656ebfdf80234978c111f67f53d4
https://pubmed.ncbi.nlm.nih.gov/34889934

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

Autor: Cantrelle, François-Xavier, Loyens, Anne, Trivelli, Xavier, Reimann, Oliver, Despres, Clément, Gandhi, Neha, Hackenberger, Christian, Landrieu, Isabelle, Smet-Nocca, Caroline

Publikováno v: Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, 2021, 14, pp.661368. ⟨10.3389/fnmol.2021.661368⟩
Frontiers in Molecular Neuroscience, Frontiers Media, 2021, 14, pp.661368. ⟨10.3389/fnmol.2021.661368⟩

International audience; Phosphorylation of the neuronal microtubule-associated Tau protein plays a critical role in the aggregation process leading to the formation of insoluble intraneuronal fibrils within Alzheimer’s disease (AD) brains. In recen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8f836a214caeac71fe864e82abd7d9
https://hal.science/hal-03428106